Results 61 to 70 of about 45,350 (212)

Environmental Enteric Dysfunction Includes a Broad Spectrum of Inflammatory Responses and Epithelial Repair ProcessesSummary

Cellular and Molecular Gastroenterology and Hepatology, 2016
Background & Aims: Environmental enteric dysfunction (EED), a chronic diffuse inflammation of the small intestine, is associated with stunting in children in the developing world.
Jinsheng Yu, M. Isabel Ordiz, Jennifer Stauber, Nurmohammad Shaikh, Indi Trehan, Erica Barnell, Richard D. Head, Ken Maleta, Phillip I. Tarr, Mark J. Manary   +9 more
doaj   +1 more source

Allosteric inhibition of IgE–FcεRI interactions by simultaneous targeting of IgE F(ab’)2 epitopes

Communications Biology
Immunoglobulin E (IgE) plays pivotal roles in allergic diseases through interaction with a high-affinity receptor (FcεRI). We established that Fab fragments of anti-IgE antibodies (HMK-12 Fab) rapidly dissociate preformed IgE-FcεRI complexes in a ...
Takao Hirano, Akemi Koyanagi, Hideo Ago, Masaki Yamamoto, Jiro Kitaura, Masataka Kasai, Ko Okumura   +6 more
doaj   +1 more source

Expression of single-chain variable fragments fused with the Fc-region of rabbit IgG in Leishmania tarentolae

Microbial Cell Factories, 2014
BackgroundIn recent years the generation of antibodies by recombinant methods, such as phage display technology, has increased the speed by which antibodies can be obtained.
M. Jørgensen, Niels Anton Friis, Jesper Just, P. Madsen, S. Petersen, P. Kristensen   +5 more
semanticscholar   +1 more source

Fragments of Bacterial Endoglycosidase S and Immunoglobulin G Reveal Subdomains of Each That Contribute to Deglycosylation

Journal of Biological Chemistry, 2014
Background: Endoglycosidase S (EndoS) is an immune evasion factor from Streptococcus pyogenes that impedes IgG effector functions by deglycosylation. Results: Analysis of fragments of enzyme and substrate identify components of each that contribute to ...
E. Dixon, Jolyon K. Claridge, D. Harvey, Kavitha Baruah, Xiaojie Yu, Snezana Vesiljevic, Susan R. Mattick, Laura K. Pritchard, B. Krishna, Christopher N. Scanlan, J. Schnell, M. Higgins, N. Zitzmann, M. Crispin   +13 more
semanticscholar   +1 more source

Fc Engineering for Developing Therapeutic Bispecific Antibodies and Novel Scaffolds

Frontiers in Immunology, 2017
Therapeutic monoclonal antibodies have become molecules of choice to treat autoimmune disorders, inflammatory diseases, and cancer. Moreover, bispecific/multispecific antibodies that target more than one antigen or epitope on a target cell or recruit ...
Hongyan Liu, A. Saxena, S. Sidhu, Donghui Wu   +3 more
semanticscholar   +1 more source

Biochemical and structural characterization of the human gut microbiome metallopeptidase IgAse provides insight into its unique specificity for the Fab' region of IgA1 and IgA2.

PLoS Pathogens
Human immunoglobulin A (IgA), comprising the isotypes IgA1 and IgA2, protects ~400 m2 of mucosal surfaces against microbial infections but can also lead to aberrant IgA deposits that cause disease. Certain bacteria have evolved peptidases that cleave the
Juan Sebastián Ramírez-Larrota, Pauline Juyoux, Pablo Guerra, Ulrich Eckhard, F Xavier Gomis-Rüth   +4 more
doaj   +1 more source

The interaction of protein A and Fc fragment of rabbit immunoglobulin G as probed by complement-fixation and nuclear-magnetic-resonance studies [PDF]

, 1977
Craig Wright, Keith J. Willan, Johan Sjödahl, Dennis R. Burton, Raymond A. Dwek   +4 more
openalex   +1 more source

Staphylococci-induced Human Platelet Injury Mediated by Protein A and Immunoglobulin G Fc Fragment Receptor [PDF]

, 1979
Jack Hawiger, S. Steckley, Dianne Hammond, C. Cheng, Sheila Timmons, Alan D. Glick, Roger M. Des Prez   +6 more
openalex   +1 more source

Immunoglobulin G3 Antibodies Specific for the 19-Kilodalton Carboxyl-Terminal Fragment ofPlasmodium yoeliiMerozoite Surface Protein 1 Transfer Protection to Mice Deficient in Fc-γRI Receptors [PDF]

, 2000
Peter Vukovic, P. Mark Hogarth, Nadine Barnes, David C. Kaslow, Michael F. Good   +4 more
openalex   +1 more source

722. Immunoglobulin Fc Fragment Tagging Enhances HBV Ag Specific T Cell Immune Responses in Mice Induced by Recombinant Lentivector Immunization [PDF]

, 2008

openalex   +1 more source