Results 181 to 190 of about 280,511 (396)
, 2018 Autoreactive B cells have a central role in the pathogenesis of rheumatoid arthritis (RA), and recent findings have proposed that anti-citrullinated protein autoantibodies (ACPA) may be directly pathogenic.
Amara, Khaled +17 more
core +1 more source
Gaussian-Chain Filters for Heavy-Tailed Noise with Application to Detecting Big Buyers and Big Sellers in Stock Market [PDF]
arXiv, 2014 We propose a new heavy-tailed distribution --- Gaussian-Chain (GC) distribution, which is inspirited by the hierarchical structures prevailing in social organizations. We determine the mean, variance and kurtosis of the Gaussian-Chain distribution to show its heavy-tailed property, and compute the tail distribution table to give specific numbers ...
arxiv
The Amino Acid Sequence of the N-Terminal 84 Residues of a Human Heavy Chain of Immunoglobulin G (Daw) [PDF]
, 1967 E. M. Press
openalex +1 more source
Common Lymphoma in an Uncommon Location
American Journal of Hematology, EarlyView.FDG avid bilateral ureteral lesions.
Jordan Carter +4 more
wiley +1 more source
Molecular basis of heavy-chain class switching and switch region deletion in an Abelson virus-transformed cell line [PDF]
, 1984 We demonstrated that a subclone of an Abelson murine leukemia virus-transformed B-lymphoid cell line switched from mu to gamma 2b expression in vitro, by the classical recombination-deletion mechanism.
Alt, Frederick W. +5 more
core
Multivariate regular variation of heavy-tailed Markov chains [PDF]
arXiv, 2007 The upper extremes of a Markov chain with regulary varying stationary marginal distribution are known to exhibit under general conditions a multiplicative random walk structure called the tail chain. More generally, if the Markov chain is allowed to switch from positive to negative extremes or vice versa, the distribution of the tail chain increment ...
arxiv
Application of humanized mice in the safety experiments of antibody drugs
Animal Models and Experimental Medicine, EarlyView.The graphical abstract of this review highlights the critical role of humanized mice in the safety evaluation of antibody drugs. First, the inherent immunogenicity of antibody drugs can lead to the production of antidrug antibodies and hypersensitivity reactions on repeated administration.
Zhimin Sun +9 more
wiley +1 more source
, 1995 Modern biotherapy has been in use for some 30 years. The first types of biotherapy were nonspecific stimulators of the immune response, but advances in genetic engineering are allowing the mass production of pure biological products which are now being ...
Gallucci, Betty Bierut +1 more
core +1 more source
Decreased Thermal Conductivity of Polyethylene Chain Influenced by Short Chain Branching [PDF]
arXiv, 2017 In this paper, we have studied the effect of short branches on the thermal conductivity of a polyethylene (PE) chain. With a reverse non-equilibrium molecular dynamics method applied, thermal conductivities of the pristine PE chain and the PE-ethyl chain are simulated and compared.
arxiv
New Horizons for Multiple Sclerosis Therapy: 2025 and Beyond
Annals of Neurology, EarlyView.The advances achieved against multiple sclerosis (MS) represent one of the great success stories of modern molecular medicine. The development of therapies with increasing selectivity and safety, guided by gains in understanding the fundamental immunology, neurobiology, genetics, and triggers of this disease, have broadened the traditional focus on ...
Joseph J. Sabatino Jr. +2 more
wiley +1 more source