Intratumoral immunoglobulin isotypes predict survival in lung adenocarcinoma subtypes [PDF]
Journal for ImmunoTherapy of Cancer, 2019 Background The role of tumor-infiltrating B-cells (TIBs) and intratumorally-produced antibodies in cancer-immunity interactions essentially remains terra incognita.
O. I. Isaeva +6 more
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Immunoglobulin Isotypes in Atlantic Salmon, Salmo Salar [PDF]
Biomolecules, 2015 There are three major immunoglobulin (Ig) isotypes in salmonid fish: IgM, IgD and IgT, defined by the heavy chains μ, δ and τ, respectively. As a result of whole genome duplication in the ancestor of the salmonid fish family, Atlantic salmon (Salmo salar)
Ivar Hordvik
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Detection of immunoglobulin isotypes from dried blood spots. [PDF]
J Immunol Methods, 2014 The study was designed to determine the sensitivity and reproducibility of recovering immunoglobulin (Ig) isotypes (IgG subclasses, IgA, IgE and IgM classes) from dried blood spots (DBS), a methodologic subcomponent of the Upstate KIDS Study. A multiplexed Luminex assay was used for IgG1/2/3/4, IgA and IgM analysis; an ELISA was used for IgE.
Andersen NJ +8 more
europepmc +5 more sources
Evolution of the Immunoglobulin Isotypes—Variations of Biophysical Properties among Animal Classes [PDF]
Biomolecules, 2023 The adaptive immune system arose around 500 million years ago in jawed fish, and, since then, it has mediated the immune defense against pathogens in all vertebrates.
Nancy D. Pomarici +4 more
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B cells defined by immunoglobulin isotypes. [PDF]
Clin Exp Immunol, 2022 SummaryThe ability of B cells to generate antibodies and provide long-lived protective immunity is the cornerstone of vaccination and has contributed to the success of modern medicine. The nine different antibody subclasses produced by humans have effector functions that differ according to antigen type and route of exposure.
James LK.
europepmc +4 more sources
The potential to improve Lyme disease diagnostics through quantification of immunoglobulin class switching patterns [PDF]
Journal of Clinical MicrobiologyN. Nair, A. Marques , E. J. Horn, G. Brown et al., J Clin Microbiol 63:e0034725, 2025, https://doi.org/10.1128/jcm.00347-25 present data to demonstrate that infection by Borrelia burgdorferi, the primary causative agent of Lyme disease in the USA, leads ...
Anna M. Schotthoefer
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Aging and immunoglobulin isotype patterns in oral tolerance [PDF]
Brazilian Journal of Medical and Biological Research, 1998 In the present review we address oral tolerance as an important biological phenomenon and discuss how it is affected by aging. Other factors such as frequency of feeding and previous digestion of the antigen also seem to influence the establishment of ...
A.M.C. Faria +8 more
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Cytokine and Antibody Isotype Responses in Vaccinated Healthcare Workers with SARS-CoV-2 Breakthrough Infections [PDF]
VirusesBackground: Healthcare workers (HCWs) are at high risk of breakthrough SARS-CoV-2 infections despite complete vaccination schedules. There are gaps in our understanding of the specific antibody isotypes and cytokine profiles produced during an infection ...
Miguel Ángel Fernández-Rojas +14 more
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Marsupial Ig genomics revisited and the potential role of retroelements in the limited number of heavy chain isotypes [PDF]
BMC BiologyBackground Marsupials have limited germline antibody heavy chain variable (VH) gene diversity and more complex light chain variable gene diversity. They also appear to have a limited repertoire of immunoglobulin heavy chain (IgH) isotypes.
Jordan M. Sampson +3 more
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Immunoglobulin isotypes and IgG subclasses in recurrent infections
The Turkish Journal of Pediatrics, 1997 The frequency of major immunoglobulin isotype and IgG subclass deficiencies among 74 children aged six months to 14 years with recurrent infections was studied.
Y Coşkun, Z Bayraktaroğlu
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