Results 11 to 20 of about 34,792 (276)

Fc-Galactosylation of Human Immunoglobulin Gamma Isotypes Improves C1q Binding and Enhances Complement-Dependent Cytotoxicity

Frontiers in Immunology, 2017
Binding of the complement component C1q to the CH2 domain of antigen-bound immunoglobulin gamma (IgG) activates the classical complement pathway and depends on its close proximity to Fc fragments of neighboring antibodies. IgG subclasses contain a highly
Benjamin Peschke, Christian W. Keller, Patrick Weber, Isaak Quast, Isaak Quast, Jan D. Lünemann, Jan D. Lünemann   +6 more
doaj   +2 more sources

Revisiting the Impact of Immunoglobulin Isotypes in Multiple Myeloma

Blood, 2020
Background Multiple Myeloma (MM) is a malignancy of terminally differentiated B lymphocytes (plasma cells, PCs) characterized by secretion of immunoglobulins and/or light chains (LCs). Association of immunoglobulin isotypes with survival in the context of contemporary therapies and accounting for modern prognostic factors has not been ...
Susan Bal, Smith Giri, Kelly N. Godby, Luciano J. Costa   +3 more
openaire   +3 more sources

Opsonization of Staphylococcus aureus by Bovine Immunoglobulin Isotypes

Journal of Dairy Science, 1993
The ability of specific bovine Ig isotypes to enhance phagocytosis of Staphylococcus aureus by polymorphonuclear neutrophils was studied. Polymorphonuclear neutrophils were isolated from the blood of 14 lactating Holstein cows. Antibodies against S. aureus M10 were produced by two Holstein cows immunized via intramuscular injections and injections in ...
A J, Guidry, L M, Berning, C N, Hambleton   +2 more
openaire   +3 more sources

Utility of immunoglobulin isotypes against LID-1 and NDO-LID for, particularly IgG1, confirming the diagnosis of multibacillary leprosy. [PDF]

Mem Inst Oswaldo Cruz, 2018
BACKGROUND Leprosy remains a health problem in many countries, with difficulties in diagnosis resulting in delayed treatment and more severe disabilities.
Marçal PHF, Fraga LAO, Mattos AMM, Menegati L, Coelho ADCO, Pinheiro RO, Sarno EN, Duthie MS, Teixeira HC.   +8 more
europepmc   +2 more sources

Differences in the immunoglobulin gene repertoires of IgG versus IgA multiple myeloma allude to distinct immunopathogenetic trajectories

Frontiers in Oncology, 2023
The analysis of the immunogenetic background of multiple myeloma (MM) has proven key to understanding disease ontogeny. However, limited information is available regarding the immunoglobulin (IG) gene repertoire in MM cases carrying different heavy chain
Glykeria Gkoliou, Glykeria Gkoliou, Andreas Agathangelidis, Georgos Karakatsoulis, Georgos Karakatsoulis, Chrysavgi Lalayanni, Apostolia Papalexandri, Alejandro Medina, Elisa Genuardi, Katerina Chlichlia, Evdoxia Hatjiharissi, Maria Papaioannou, Evangelos Terpos, Cristina Jimenez, Ioanna Sakellari, Simone Ferrero, Marco Ladetto, Ramon Garcia Sanz, Chrysoula Belessi, Kostas Stamatopoulos, Kostas Stamatopoulos   +20 more
doaj   +1 more source

Origin of Immunoglobulin Isotype Switching [PDF]

Current Biology, 2012
From humans to frogs, immunoglobulin class switching introduces different effector functions to antibodies through an intrachromosomal DNA recombination process at the heavy-chain locus. Although there are two conventional antibody classes (IgM, IgW) in sharks, their heavy chains are encoded by 20 to >100 miniloci. These representatives of the earliest
Zhu, Catherine, Lee, Victor, Finn, Alyssa, Senger, Kate, Zarrin, Ali A., Du Pasquier, Louis, Hsu, Ellen   +6 more
openaire   +3 more sources

How Estrogen, Testosterone, and Sex Differences Influence Serum Immunoglobulin Isotype Patterns in Mice and Humans

Viruses, 2023
Females often exhibit superior immune responses compared to males toward vaccines and pathogens such as influenza viruses and SARS-CoV-2. To help explain these differences, we first studied serum immunoglobulin isotype patterns in C57BL/6 male and female
Sherri L. Surman, Bart G. Jones, Rhiannon R. Penkert, Robert E. Sealy, Tony Marion, Paul G. Thomas, Geoffrey Neale, Beisi Xu, Julia L. Hurwitz   +8 more
doaj   +1 more source

Dynamics of immunoglobulin G subclasses during the first two years of life in Malawian infants born to HIV-positive mothers

BMC Pediatrics, 2020
Background Maternal antibodies are key components of the protective responses of infants who are unable to produce their own IgG until 6 months of life. There is evidence that HIV-exposed uninfected children (HEU) have IgG levels abnormalities, that can ...
Silvia Baroncelli, Clementina Maria Galluzzo, Giuseppe Liotta, Mauro Andreotti, Stefano Orlando, Fausto Ciccacci, Haswell Jere, Richard Luhanga, Jean Baptiste Sagno, Roberta Amici, Maria Cristina Marazzi, Marina Giuliano   +11 more
doaj   +1 more source

Immunoglobulin isotype influences affinity and specificity [PDF]

Proceedings of the National Academy of Sciences, 2012
For almost half a century the Ig molecule has been considered a bifunctional molecule consisting of two independent regions, a variable (V) region responsible for specificity and affinity, and a constant (C) region responsible for such effector functions as complement activation and interaction with Fc receptors.
Arturo, Casadevall, Alena, Janda
openaire   +2 more sources

Onset of immune senescence defined by unbiased pyrosequencing of human immunoglobulin mRNA repertoires. [PDF]

PLoS ONE, 2012
The immune system protects us from foreign substances or pathogens by generating specific antibodies. The variety of immunoglobulin (Ig) paratopes for antigen recognition is a result of the V(D)J rearrangement mechanism, while a fast and efficient immune
Florian Rubelt, Volker Sievert, Florian Knaust, Christian Diener, Theam Soon Lim, Karl Skriner, Edda Klipp, Richard Reinhardt, Hans Lehrach, Zoltán Konthur   +9 more
doaj   +1 more source