Results 51 to 60 of about 34,792 (276)

Ig heavy chain genes and their locus in grass carp Ctenopharyngodon idella [PDF]

, 2010
The cDNA and genomic sequences of IgD and IgZ were characterized in grass carp Ctenopharyngodon idella in the present study, and with the identification of a BAC clone covering zeta, mu, and delta genes, the IgH locus containing these Ig genes and other ...
Chang, M. X., Gao, Q., Nie, P, Chinese Acad Sci, State Key Lab Freshwater Ecol & Biotechnol, Inst Hydrobiol, Wuhan 430072, Hubei Province, Peoples R China, Nie, P., Wang, X. X., Wang, Y. P., Xiao, F. S., Xu, Q. Q., Yan, W., Yao, W. J.   +9 more
core   +1 more source

Signaling via interleukin-4, receptor alpha chain is required for successful vaccination against schistosomiasis in BALB/c mice [PDF]

, 2001
Radiation-attenuated (RA) schistosome larvae are potent stimulators of innate immune responses at the skin site of exposure (pinna) that are likely to be important factors in the development of Th1-mediated protective immunity.
Anderson S., Anderson S., Anderson S., Artis D., Bancroft A. J., Bancroft A. J., Barner M., Belkaid Y., Brewer J. M., Brombacher F., Coulson P. S., D'Andrea A., de Andres B., Dean D. A., Delgado V., Donaldson D. D., Faquim-Mauro E. L., Galbiati F., Grunig G., Guler M. L., Hilton D. J., Hoffmann K. F., Hsieh C. S., James S. L., Jankovic D., Jankovic D., Jankovic D., King C. L., King C. L., Kopf M., Magram J., Mangold B. L., Matthews D. J., Mattner F., McKenzie G. J., Metwali A., Mohrs M., Mohrs M., Mountford A. P., Mountford A. P., Mountford A. P., Mountford A. P., Mountford A. P., Mountford A. P., Muchamuel T., Nelms K., Noben-Trauth N., Noben-Trauth N., Noben-Trauth N., O'Garra A., Pearce E. J., Reiner S. L., Scott P., Seder R. A., Sher A., Shibuya K., Smythies L. E., Smythies L. E., Street M., Szabo S. J., Urban J. F., Wilson R. A., Wynn T. A., Wynn T. A., Zurawski G.   +64 more
core   +2 more sources

Eosinophils Are Important for Protection, Immunoregulation and Pathology during Infection with Nematode Microfilariae [PDF]

, 2014
Eosinophil responses typify both allergic and parasitic helminth disease. In helminthic disease, the role of eosinophils can be both protective in immune responses and destructive in pathological responses. To investigate whether eosinophils are involved
AA Humbles, AD Doyle, AD Klion, AE O'Connell, AM Galioto, Anita Y. N. Cheung, Ashleigh C. Johnston, BA Vallance, CA Gray, CA Gray, CS Enobe, D Abraham, D Voehringer, DR Herbert, E Pearlman, E Pinelli, EA Jacobsen, Emma T. Cadman, ET Cadman, H Kita, James J. Lee, JE Simons, JE Simons, JH Schroeder, JJ Lee, Katherine A. Thysse, KJ Hamann, KL Denzler, KL Denzler, L Le Goff, L O'Bryan, LA Spencer, LR Hall, M Lomask, M Witzenrath, ML Knott, PC Fulkerson, PL Milton, RA Lawrence, RA Lawrence, Rachel A. Lawrence, RK Mehlotra, S Pegorier, S Specht, SA Babayan, SI Ochkur, Siobhan Bearder, T Carter, T Ramalingam, T Ramalingam, Thomas B. Nutman, V Fabre, W Mitzner   +52 more
core   +4 more sources

Influence of immunoglobulin isotype on therapeutic antibody function [PDF]

Blood, 2016
AbstractMonoclonal antibody (mAb) therapeutics are revolutionizing cancer treatment; however, not all tumors respond, and agent optimization is essential to improve outcome. It has become clear over recent years that isotype choice is vital to therapeutic success with agents that work through different mechanisms, direct tumor targeting, agonistic ...
Beers, S., Glennie, M., White, A.
openaire   +3 more sources

Immunoglobulin D multiple myeloma, plasma cell leukemia and chronic myelogenous leukemia in a single patient treated simultaneously with lenalidomide, bortezomib, dexamethasone and imatinib

Hematology Reports, 2016
Multiple myeloma (MM) is a neoplastic lymphoproliferative disorder characterized by uncontrolled monoclonal plasma cell proliferation. Among different isotypes of MM, immunoglobulin D (IgD) MM is very rare, representing only 1 to 2% of all isotypes ...
Naveed Ali, Peter V. Pickens, Herbert E. Auerbach   +2 more
doaj   +1 more source

Immunoglobulin profile and B‐cell frequencies are altered with changes in the cellular microenvironment independent of the stimulation conditions

Immunity, Inflammation and Disease, 2020
Introduction B‐cells are essential in the defense against Mycobacterium tuberculosis. Studies on isolated cells may not accurately reflect the responses that occur in vivo due to the presence of other cells.
Dannielle K. Moore, Gina R. Leisching, Candice I. Snyders, Andrea Gutschmidt, Ilana C. vanRensburg, Andre G. Loxton   +5 more
doaj   +1 more source

Immunoproteomics reveal increased serum IgG3/5 binding to Dermatophagoides and yeast protein antigens in severe equine asthma in a preliminary study

Frontiers in Immunology, 2023
IntroductionSevere equine asthma (SEA) is a common, chronic respiratory disease of horses characterized by hyperreactivity to hay dust which has many similarities to severe neutrophilic asthma in humans.
Christiane L. Schnabel, Maria-Christin Jentsch, Sabrina Lübke, Sarah Kaiser-Thom, Vinzenz Gerber, Susanne Vrtala, Huey-Jy Huang, Claudio Rhyner, Claudio Rhyner, Bettina Wagner, Ralf Hoffmann, Daniela  Volke   +11 more
doaj   +1 more source

Amino-functionalized poly(l-lactide) lamellar single crystals as a valuable substrate for delivery of HPV16-E7 tumor antigen in vaccine development [PDF]

, 2015
Background: Poly(L-lactide) (PLLA) is a biodegradable polymer currently used in many biomedical applications, including the production of resorbable surgical devices, porous scaffolds for tissue engineering, nanoparticles and microparticles for the ...
Accardi, Luisa, Ammendolia, Maria Grazia, Casini, Gabriele, D'ILARIO, LUCIO, Di Bonito, Paola, FRANCOLINI, IOLANDA, MARTINELLI, Andrea, Petrone, Linda, PIOZZI, Antonella   +8 more
core   +2 more sources

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Functions of IgM fc receptor (FcµR) related to autoimmunity

Autoimmunity
Unlike Fc receptors for switched immunoglobulin (Ig) isotypes, Fc receptor for IgM (FcµR) is selectively expressed by lymphocytes. The ablation of the FcµR gene in mice impairs B cell tolerance as evidenced by concomitant production of autoantibodies of ...
Hiromi Kubagawa, Pedram Mahmoudi Aliabadi, Khlowd Al-Qaisi, Peter K. Jani, Kazuhito Honjo, Shozo Izui, Andreas Radbruch, Fritz Melchers   +7 more
doaj   +1 more source