Results 151 to 160 of about 14,210 (195)
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Two Structurally Distinct Classes of Kappa-chains in Human Immunoglobulins
Nature, 1967THE general structural features of the various types of immunoglobulins are known and the details of the primary structure are gradually being filled in. A characteristic feature of the immune response, however, is its specificity and here the data have not been sufficient to reveal the structural basis of the specificity and even less the underlying ...
H D, Niall, P, Edman
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Rearrangement-Enhancing Element Upstream of the Mouse Immunoglobulin Kappa Chain J Cluster
Science, 1996Transcriptional regulatory elements have been shown to be necessary but not sufficient for the developmental regulation of immunoglobulin gene rearrangement in mouse precursor B cells. In the chicken λ light chain locus, additional elements in the V-J intervening sequence are involved in negative and positive regulation of rearrangement ...
L, Ferradini +5 more
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The organization of immunoglobulin variable kappa chain genes on mouse chromosome 6
Immunogenetics, 1986One mouse with a known recombination (NAK) at the Igk locus on chromosome 6 and two new recombinants [B6.PL (75NS) and B6.PL (85NS)] were examined using a series of probes, each of which is specific for a set of immunoglobulin (Ig) Vk genes. Under high stringency conditions, each probe detects from 1 to 19 Bam HI restriction endonuclease fragments ...
L A, D'Hoostelaere, D M, Gibson
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Journal of Surgical Research, 2005
A number of the research into the pathogenesis of the abdominal aortic aneurysm (AAA) have focused on the alteration of gene expression. The current technique for elucidating alterations of gene expression has a setback in that many artifact complementary DNA (cDNA) products present abnormal polymerase chain reaction (PCR) amplification.
Dong-Ik, Kim +2 more
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A number of the research into the pathogenesis of the abdominal aortic aneurysm (AAA) have focused on the alteration of gene expression. The current technique for elucidating alterations of gene expression has a setback in that many artifact complementary DNA (cDNA) products present abnormal polymerase chain reaction (PCR) amplification.
Dong-Ik, Kim +2 more
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Mouse Immunoglobulin Kappa Chain MPC 11: Extra Amino-Terminal Residues
Science, 1973The kappa chain from the immunoglobulin of myeloma tumor MPC 11 has 12 extra residues at its amino terminus, the first six of which are identical to the residues at positions 1 to 6 of typical mouse kappa chains and at positions 13 to 18 of MPC 11 itself.
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Science, 1970
The amino terminal portion of 20 kappa chains from the highly inbred BALB/c mouse has been examined on an automatic protein sequencer. These proteins can be divided into at least nine groups (subgroups) based on sequence patterns which are so distinct that each subgroup is probably encoded by at least one germ-line gene.
Hood, L E, Potter, M, Kean, D J
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The amino terminal portion of 20 kappa chains from the highly inbred BALB/c mouse has been examined on an automatic protein sequencer. These proteins can be divided into at least nine groups (subgroups) based on sequence patterns which are so distinct that each subgroup is probably encoded by at least one germ-line gene.
Hood, L E, Potter, M, Kean, D J
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Generation of a mouse strain that produces immunoglobulin kappa chains with human constant regions
Science, 1993Humanized antibodies are highly efficient as immunotherapeutic reagents and have many advantages over rodent antibodies. A mouse strain was generated by gene targeting to replace the mouse kappa light chain constant (C) region gene with the human C kappa gene.
Y R, Zou, H, Gu, K, Rajewsky
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Synthesis and glycosylation of the MOPC-46B immunoglobulin kappa chain in Xenopus laevis oocytes
Biochemical and Biophysical Research Communications, 1977Abstract Polyadenylated mRNA isolated from MOPC-46B plasmacytoma, which secretes a glycosylated kappa chain, was injected into Xenopus laevis oocytes. Analysis of the resulting product showed that [1-14C]mannose was incorporated into the MOPC-46B kappa chain.
R L, Jilka +3 more
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Journal of Molecular Biology, 1974
Abstract The messenger RNA for an immunoglobulin light (kappa) chain was isolated from the mouse myeloma MOPC41 and shown to be almost twofold longer than necessary to code for its protein product. DNA complementary to the mRNA was synthesized with the RNA-directed DNA polymerase of Rous sarcoma virus.
Stavnezer, Janet +3 more
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Abstract The messenger RNA for an immunoglobulin light (kappa) chain was isolated from the mouse myeloma MOPC41 and shown to be almost twofold longer than necessary to code for its protein product. DNA complementary to the mRNA was synthesized with the RNA-directed DNA polymerase of Rous sarcoma virus.
Stavnezer, Janet +3 more
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Evolution of the rabbit immunoglobulin kappa chain genes.
Immunogenetics, 1991We have analyzed the organization and the structure of rabbit kappa chain genes encoding b allotypes in wild rabbits. The kappa 1 gene of the b95 allotype was cloned and its structure determined. The J region is composed of five segments but only J2 appears to be functional and is identical to the J2 segment of the b4 allotype.
H, Ayadi, P N, Marche, P A, Cazenave
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