Cubebene‐related sesquiterpenes, found across diverse biological sources, exhibit promising pharmacological activities, including anti‐inflammatory, neuroprotective, and anticancer effects. This review highlights their molecular diversity, ADME profiles, and predicted multitarget interactions, underscoring their therapeutic relevance and potential in ...
Khadija Boualam +4 more
wiley +1 more source
Kappa free light chain index in CSF diagnostics: the impact of different immunoglobulin isotypes. [PDF]
Schmidauer M +9 more
europepmc +1 more source
MyoRep: A Novel Reporter System to Detect Early Muscle Atrophy In Vitro and In Vivo
ABSTRACT Background Muscle atrophy occurs during physiological (i.e., fasting) and pathological conditions (i.e., cancer) and anticipates death. Since not all patients will undergo muscle wasting, it would be highly useful to identify them soon to intervene early.
Andrea D. Re Cecconi +11 more
wiley +1 more source
Rituximab combined with lenalidomide for the treatment of marginal zone lymphoma with IgM kappa positivity and cold agglutinin syndrome: a case report. [PDF]
Zhang X, Zheng Y, Cai S.
europepmc +1 more source
ABSTRACT Translocations involving CCND1 are well described in multiple myeloma (MM), most frequently t(11;14), but rearrangements involving the immunoglobulin kappa (IGK) locus are rare. We present a case of a 71‐year‐old female with MM harboring t(2;11)(p11.2;q13), resulting in IGK::CCND1, with cyclin D1 and BCL‐2 overexpression.
Ariel Siegel +7 more
wiley +1 more source
An Unusual Pattern of Hepatic Involvement in Plasma Cell Leukemia. [PDF]
Paz MAM +6 more
europepmc +1 more source
ABSTRACT Monoclonal immunoglobulin deposition disease (MIDD) is a plasma cell disorder where immunoglobulin light‐ and/or heavy‐chains accumulate in various organs. Hepatic involvement can be challenging to diagnose, as manifestations are protean and Congo red staining is negative.
Bella L. Liu +5 more
wiley +1 more source
Comparative analysis of three different serum-free light chain assays in the diagnosis of multiple myeloma. [PDF]
Cui F +6 more
europepmc +1 more source
Oxidative Stress and DNA Epigenetic Modifications in Cancer: Mechanisms and Targeted Therapeutics
Reactive oxygen species (ROS) modulate DNA methyltransferases (DNMTs), ten‐eleven translocation family proteins (TETs) and their cofactors, reshaping 5‐methylcytosine (5mC)/5‐hydroxymethylcytosine (5hmC)/5‐formylcytosine (5fC) landscapes and gene expression in cancer cells. In turn, epigenetic control of antioxidant and metabolic pathways feeds back on
Xishan Yang +7 more
wiley +1 more source
A non-affinity-dependent high-resolution mass spectrometry method for detecting and typing monoclonal free light immunoglobulin chains. [PDF]
Bengtson P, Förnvik Jonsson M.
europepmc +1 more source

