Results 181 to 190 of about 74,618 (225)

Age-related isomerization of Asp in human immunoglobulin G kappa chain

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2020
Isomerization of aspartate (Asp) is a common non-enzymatic posttranslational modification. Isomerized residues accumulate in proteins associated with age-related human disorders such as cataract and are well known to affect protein structure and function. We previously detected d-Asp-containing peptides in human serum.
Seongmin, Ha, Tadatoshi, Kinouchi, Noriko, Fujii   +2 more
openaire   +2 more sources

Isolation of messenger RNA for an immunoglobulin kappa chain and enumeration of the genes for the constant region of kappa chain in the mouse

Journal of Molecular Biology, 1974
Abstract The messenger RNA for an immunoglobulin light (kappa) chain was isolated from the mouse myeloma MOPC41 and shown to be almost twofold longer than necessary to code for its protein product. DNA complementary to the mRNA was synthesized with the RNA-directed DNA polymerase of Rous sarcoma virus.
Stavnezer, Janet, Huang, R. C., Stavnezer, E., Bishop, J. M.   +3 more
openaire   +3 more sources

Two Structurally Distinct Classes of Kappa-chains in Human Immunoglobulins

Nature, 1967
THE general structural features of the various types of immunoglobulins are known and the details of the primary structure are gradually being filled in. A characteristic feature of the immune response, however, is its specificity and here the data have not been sufficient to reveal the structural basis of the specificity and even less the underlying ...
H D, Niall, P, Edman
openaire   +2 more sources

Single light chain subclass (kappa chain) immunoglobulin deposition in glomerulonephritis

Human Pathology, 1985
Renal glomerular disease characterized by the deposition of immunoglobulin light chains or monoclonal immunoglobulins was demonstrated by immunofluorescence microscopy in 11 patients. The most common histopathologic findings were those of mesangiocapillary glomerulonephritis, but considerable variability was observed.
C E, Alpers, W H, Tu, J, Hopper, C G, Biava   +3 more
openaire   +2 more sources

Cerebrospinal fluid kappa and lambda free light chains in oligoclonal band‐negative patients with suspected multiple sclerosis

European Journal of Neurology, 2019
Cerebrospinal fluid (CSF) kappa free light chains (FLCs) may be a more sensitive marker of intrathecal immunoglobulin (Ig)G synthesis compared with oligoclonal bands (OCBs).
D. Ferraro, A. Trovati, R. Bedin, P. Natali, D. Franciotta, M. Santangelo, V. Camera, F. Vitetta, M. Varani, T. Trenti, M. Gastaldi, S. De Biasi, M. Nasi, M. Pinti, S. Meletti, P. Sola   +15 more
semanticscholar   +1 more source

The organization of immunoglobulin variable kappa chain genes on mouse chromosome 6

Immunogenetics, 1986
One mouse with a known recombination (NAK) at the Igk locus on chromosome 6 and two new recombinants [B6.PL (75NS) and B6.PL (85NS)] were examined using a series of probes, each of which is specific for a set of immunoglobulin (Ig) Vk genes. Under high stringency conditions, each probe detects from 1 to 19 Bam HI restriction endonuclease fragments ...
L A, D'Hoostelaere, D M, Gibson
openaire   +2 more sources

Rearrangement-Enhancing Element Upstream of the Mouse Immunoglobulin Kappa Chain J Cluster

Science, 1996
Transcriptional regulatory elements have been shown to be necessary but not sufficient for the developmental regulation of immunoglobulin gene rearrangement in mouse precursor B cells. In the chicken λ light chain locus, additional elements in the V-J intervening sequence are involved in negative and positive regulation of rearrangement ...
L, Ferradini, H, Gu, A, De Smet, K, Rajewsky, C A, Reynaud, J C, Weill   +5 more
openaire   +2 more sources

The structure and evolution of immunoglobulin kappa chain constant region genes in the genus Rattus

Molecular Immunology, 1987
We have cloned and sequenced the C-kappa (Ck) genes from seven species and subspecies of rats which have diverged over the past few million years in Australia. Comparisons of these sequences with each other and the Ck genes of the laboratory rat, Rattus norvegicus, indicate noncoding regions have accumulated fewer mutations than adjacent coding ...
M B, Frank, R M, Besta, P R, Baverstock, G A, Gutman   +3 more
openaire   +2 more sources

Synthesis and glycosylation of the MOPC-46B immunoglobulin kappa chain in Xenopus laevis oocytes

Biochemical and Biophysical Research Communications, 1977
Abstract Polyadenylated mRNA isolated from MOPC-46B plasmacytoma, which secretes a glycosylated kappa chain, was injected into Xenopus laevis oocytes. Analysis of the resulting product showed that [1-14C]mannose was incorporated into the MOPC-46B kappa chain.
R L, Jilka, R L, Cavalieri, L, Yaffe, S, Pestka   +3 more
openaire   +2 more sources

Cerebrospinal fluid free kappa light chains and kappa index perform equal to oligoclonal bands in the diagnosis of multiple sclerosis

Clinical Chemistry and Laboratory Medicine, 2018
Background Detection of intrathecal immunoglobulin G (IgG) synthesis by gold standard oligoclonal bands (OCB) or IgG index remains an integral part of multiple sclerosis (MS) diagnostics, although both methods have weaknesses.
Mikael Christiansen, M. C. Gjelstrup, Morten Stilund, T. Christensen, T. Petersen, Holger Jon Møller   +5 more
semanticscholar   +1 more source