Results 261 to 270 of about 29,558 (298)
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Rearrangement-Enhancing Element Upstream of the Mouse Immunoglobulin Kappa Chain J Cluster
Science, 1996Transcriptional regulatory elements have been shown to be necessary but not sufficient for the developmental regulation of immunoglobulin gene rearrangement in mouse precursor B cells. In the chicken λ light chain locus, additional elements in the V-J intervening sequence are involved in negative and positive regulation of rearrangement ...
L, Ferradini +5 more
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The structure and evolution of immunoglobulin kappa chain constant region genes in the genus Rattus
Molecular Immunology, 1987We have cloned and sequenced the C-kappa (Ck) genes from seven species and subspecies of rats which have diverged over the past few million years in Australia. Comparisons of these sequences with each other and the Ck genes of the laboratory rat, Rattus norvegicus, indicate noncoding regions have accumulated fewer mutations than adjacent coding ...
M B, Frank +3 more
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Synthesis and glycosylation of the MOPC-46B immunoglobulin kappa chain in Xenopus laevis oocytes
Biochemical and Biophysical Research Communications, 1977Abstract Polyadenylated mRNA isolated from MOPC-46B plasmacytoma, which secretes a glycosylated kappa chain, was injected into Xenopus laevis oocytes. Analysis of the resulting product showed that [1-14C]mannose was incorporated into the MOPC-46B kappa chain.
R L, Jilka +3 more
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Generation of a mouse strain that produces immunoglobulin kappa chains with human constant regions
Science, 1993Humanized antibodies are highly efficient as immunotherapeutic reagents and have many advantages over rodent antibodies. A mouse strain was generated by gene targeting to replace the mouse kappa light chain constant (C) region gene with the human C kappa gene.
Y R, Zou, H, Gu, K, Rajewsky
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Immunogenetics, 2008
We describe a bioinformatic analysis of germline and rearranged immunoglobulin kappa chain (IGK) gene sequences, performed in order to assess the completeness and reliability of the reported IGK repertoire. In contrast to the reported heavy-chain gene repertoire, which includes many dubious sequences, only five IGK variable gene (IGKV) alleles appear ...
Andrew M, Collins +5 more
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We describe a bioinformatic analysis of germline and rearranged immunoglobulin kappa chain (IGK) gene sequences, performed in order to assess the completeness and reliability of the reported IGK repertoire. In contrast to the reported heavy-chain gene repertoire, which includes many dubious sequences, only five IGK variable gene (IGKV) alleles appear ...
Andrew M, Collins +5 more
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Journal of Surgical Research, 2005
A number of the research into the pathogenesis of the abdominal aortic aneurysm (AAA) have focused on the alteration of gene expression. The current technique for elucidating alterations of gene expression has a setback in that many artifact complementary DNA (cDNA) products present abnormal polymerase chain reaction (PCR) amplification.
Dong-Ik, Kim +2 more
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A number of the research into the pathogenesis of the abdominal aortic aneurysm (AAA) have focused on the alteration of gene expression. The current technique for elucidating alterations of gene expression has a setback in that many artifact complementary DNA (cDNA) products present abnormal polymerase chain reaction (PCR) amplification.
Dong-Ik, Kim +2 more
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Evolution of the rabbit immunoglobulin kappa chain genes.
Immunogenetics, 1991We have analyzed the organization and the structure of rabbit kappa chain genes encoding b allotypes in wild rabbits. The kappa 1 gene of the b95 allotype was cloned and its structure determined. The J region is composed of five segments but only J2 appears to be functional and is identical to the J2 segment of the b4 allotype.
H, Ayadi, P N, Marche, P A, Cazenave
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Molecular Defects in a Human Immunoglobulin κ Chain Deficiency
Science, 1985The molecular basis of a human immunoglobulin deficiency characterized by the complete absence of κ chains has been investigated by nucleotide sequence analyses of a patient's κ constant region (C κ ) genes. Both of his C κ genes had a single point mutation, resulting in the loss of the ...
Stavnezer, Janet +2 more
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Immunogenetics, 1989
The mouse Igk-VSer gene encodes an immunoglobulin kappa light chain variable region which gives rise to two phenotypic polymorphisms of mouse kappa chains. The nucleotide sequences of coding and flanking regions of the Igk-VSerc and Igk-VSerd alleles found in recently inbred strains of wild mice are compared with those of the Igk-VSera and Igk-VSerb ...
P D, Ponath, D M, Hillis, P D, Gottlieb
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The mouse Igk-VSer gene encodes an immunoglobulin kappa light chain variable region which gives rise to two phenotypic polymorphisms of mouse kappa chains. The nucleotide sequences of coding and flanking regions of the Igk-VSerc and Igk-VSerd alleles found in recently inbred strains of wild mice are compared with those of the Igk-VSera and Igk-VSerb ...
P D, Ponath, D M, Hillis, P D, Gottlieb
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Mouse Immunoglobulin Kappa Chain MPC 11: Extra Amino-Terminal Residues
Science, 1973The kappa chain from the immunoglobulin of myeloma tumor MPC 11 has 12 extra residues at its amino terminus, the first six of which are identical to the residues at positions 1 to 6 of typical mouse kappa chains and at positions 13 to 18 of MPC 11 itself.
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