Results 261 to 270 of about 765,793 (291)

Differential Expression of Immunoglobulin Kappa Chain Constant Region in Human Abdominal Aortic Aneurysm

Journal of Surgical Research, 2005
A number of the research into the pathogenesis of the abdominal aortic aneurysm (AAA) have focused on the alteration of gene expression. The current technique for elucidating alterations of gene expression has a setback in that many artifact complementary DNA (cDNA) products present abnormal polymerase chain reaction (PCR) amplification.
Dong-Ik, Kim, Hyun-Seon, Eo, Jin-Hyun, Joh   +2 more
openaire   +2 more sources

Molecular Defects in a Human Immunoglobulin κ Chain Deficiency

Science, 1985
The molecular basis of a human immunoglobulin deficiency characterized by the complete absence of κ chains has been investigated by nucleotide sequence analyses of a patient's κ constant region (C κ ) genes. Both of his C κ genes had a single point mutation, resulting in the loss of the ...
Stavnezer, Janet, Kekish, O., Zegers, B. J.   +2 more
openaire   +3 more sources

Structural and evolutionary comparisons of four alleles of the mouse immunoglobulin kappa chain gene,Igk-VSer

Immunogenetics, 1989
The mouse Igk-VSer gene encodes an immunoglobulin kappa light chain variable region which gives rise to two phenotypic polymorphisms of mouse kappa chains. The nucleotide sequences of coding and flanking regions of the Igk-VSerc and Igk-VSerd alleles found in recently inbred strains of wild mice are compared with those of the Igk-VSera and Igk-VSerb ...
P D, Ponath, D M, Hillis, P D, Gottlieb
openaire   +2 more sources

Mouse Immunoglobulin Kappa Chain MPC 11: Extra Amino-Terminal Residues

Science, 1973
The kappa chain from the immunoglobulin of myeloma tumor MPC 11 has 12 extra residues at its amino terminus, the first six of which are identical to the residues at positions 1 to 6 of typical mouse kappa chains and at positions 13 to 18 of MPC 11 itself.
openaire   +2 more sources

Chromosomal Translocation Involving the Immunoglobulin Kappa-Chain and Heavy-Chain Loci in a Child with Chronic Lymphocytic Leukemia

New England Journal of Medicine, 1983
Chronic lymphocytic leukemia is usually a monoclonal B-cell neoplasm that occurs almost exclusively in middle-aged and elderly adults. We observed a rapidly progressive case of the disease in a 10-year-old girl. The leukemic cells bore surface IgM and IgD immunoglobulins of the kappa-light-chain type.
J A, Sonnier, G R, Buchanan, P N, Howard-Peebles, J, Rutledge, R G, Smith   +4 more
openaire   +2 more sources

Relative diagnostic value of cerebrospinal fluid kappa chains in MS

Neurology, 1989
We used receiver operating characteristic (ROC) curve analysis to determine the relative performance of different CSF IgG parameters as diagnostic markers for multiple sclerosis. We quantitated CSF and serum IgG and albumin to determine an IgG albumin ratio, IgG index, Tourtellotte's synthesis rate, and Schuller's formula; CSF free kappa light chains ...
R A, Rudick, C A, French, D, Breton, G W, Williams   +3 more
openaire   +2 more sources

Demonstration of the clonality and specificity of an auto-antibody response to a suppressed immunoglobulin allotype of the rabbit kappa chain b locus

Immunology Letters, 1985
A regulatory idiotypic network is proposed to control allotype expression in normal rabbits. We have used suppression of the kappa chain b6 allotype in an attempt to restrict the number of regulatory idiotypes involved in an induced auto anti-allotype response.
N, Hole, D, Catty, P, Appleby, J, Catty
openaire   +2 more sources

Monoclonal antibodies against common and Igk-1a allotypic determinants of rat immunoglobulin kappa chain constant domain

Immunology Letters, 1985
SJL/J mice were immunized with polyclonal rat Ig light chains of two allotypes and immune spleen cells were fused with P3-Ag8.653 myeloma cells. 17 cell populations producing antirat Ig AB were cloned. Four clones, 1G9, L3E8, L2B2 and L2C5 have been characterized in detail. All MABs are of the IgG1, kappa isotype.
Cherapakhin, V V, Chervonsky, A V, Filatov, A V, Rokhlin, O V   +3 more
openaire   +2 more sources

Diversity in the rabbit immunoglobulin kappa chain variable regions is amplified by nucleotide deletions and insertions at the V-J junction

Cell, 1983
To analyze the rabbit immunoglobulin kappa locus, we isolated, from a phenotypically homozygous b4/b4 rabbit genomic library, a C kappa gene corresponding to the b4 var allelic form of the b4 C kappa gene. We also determined the nucleotide sequence of the J kappa cluster 3 kb upstream of the b4 var C kappa gene.
O, Heidmann, F, Rougeon
openaire   +2 more sources

[Tissue-specific transcription of the gene for immunoglobulin kappa-chains in a cell-free system].

Molekuliarnaia biologiia, 1988
The x gene of immunoglobulin is effectively transcribed in extracts from homologous, i. e. lymphoid cells; the transcription is weak and incorrect in a heterologous system. x gene fragments with deletions in the 5'-region of the gene and with transpositions of the enhancer have been constructed.
V A, Adzhalov, O L, Polianovskiĭ
openaire   +1 more source