Results 271 to 280 of about 29,558 (298)

Relative diagnostic value of cerebrospinal fluid kappa chains in MS

Neurology, 1989
We used receiver operating characteristic (ROC) curve analysis to determine the relative performance of different CSF IgG parameters as diagnostic markers for multiple sclerosis. We quantitated CSF and serum IgG and albumin to determine an IgG albumin ratio, IgG index, Tourtellotte's synthesis rate, and Schuller's formula; CSF free kappa light chains ...
R A, Rudick, C A, French, D, Breton, G W, Williams   +3 more
openaire   +2 more sources

Chromosomal Translocation Involving the Immunoglobulin Kappa-Chain and Heavy-Chain Loci in a Child with Chronic Lymphocytic Leukemia

New England Journal of Medicine, 1983
Chronic lymphocytic leukemia is usually a monoclonal B-cell neoplasm that occurs almost exclusively in middle-aged and elderly adults. We observed a rapidly progressive case of the disease in a 10-year-old girl. The leukemic cells bore surface IgM and IgD immunoglobulins of the kappa-light-chain type.
J A, Sonnier, G R, Buchanan, P N, Howard-Peebles, J, Rutledge, R G, Smith   +4 more
openaire   +2 more sources

Demonstration of the clonality and specificity of an auto-antibody response to a suppressed immunoglobulin allotype of the rabbit kappa chain b locus

Immunology Letters, 1985
A regulatory idiotypic network is proposed to control allotype expression in normal rabbits. We have used suppression of the kappa chain b6 allotype in an attempt to restrict the number of regulatory idiotypes involved in an induced auto anti-allotype response.
N, Hole, D, Catty, P, Appleby, J, Catty
openaire   +2 more sources

[Tissue-specific transcription of the gene for immunoglobulin kappa-chains in a cell-free system].

Molekuliarnaia biologiia, 1988
The x gene of immunoglobulin is effectively transcribed in extracts from homologous, i. e. lymphoid cells; the transcription is weak and incorrect in a heterologous system. x gene fragments with deletions in the 5'-region of the gene and with transpositions of the enhancer have been constructed.
V A, Adzhalov, O L, Polianovskiĭ
openaire   +1 more source

Development of immunoglobulin lambda-chain-positive B cells, but not editing of immunoglobulin kappa-chain, depends on NF-kappaB signals.

Nature immunology, 2009
By genetically ablating IkappaB kinase (IKK)-mediated activation of the transcription factor NF-kappaB in the B cell lineage and by analyzing a mouse mutant in which immunoglobulin lambda-chain-positive B cells are generated in the absence of rearrangements in the locus encoding immunoglobulin kappa-chain, we define here two distinct, consecutive ...
Derudder, E, Cadera, E J, Vahl, J C, Wang, J, Fox, C J, Zha, S, van, Loo G, Pasparakis, M, Schlissel, M S, Schmidt, Supprian M, Rajewsky, K   +10 more
openaire   +2 more sources

Bence Jones proteins and light chains of immunoglobulins. II. Immunochemical differentiation and classification of kappa-chains.

The Journal of experimental medicine, 1970
Three distinct classes of kappa light polypeptide chains have been detected immunochemically by an antiserum (R185) prepared against a kappa Bence Jones protein with a glutamyl amino terminal residue. This antiserum had specificity for kappa light chains with glutamyl amino terminal residues and differentiated kappa-chains with aspartyl amino terminal ...
A, Solomon, C L, McLaughlin
openaire   +1 more source

Molecular cloning of seven mouse immunoglobulin .kappa. chain messenger ribonucleic acids

Biochemistry, 1980
N M, Gough, E A, Webb, S, Cory, J M, Adams   +3 more
openaire   +2 more sources

High sensitivity of free lambda and free kappa light chains for detection of intrathecal immunoglobulin synthesis in cerebrospinal fluid

Acta Neurologica Scandinavica, 2009
Frank Birklein
exaly  

Measurement of free kappa immunoglobulin light chains in the cerebrospinal fluid by a competitive avidin—biotin ELISA

Clinica Chimica Acta, 1989
Francesco Lolli
exaly  

Expression of immunoglobulin kappa and lambda chains in mink

European Journal of Immunology, 1993
Ludmila Mechetina, Alexander V Taranin
exaly