Results 251 to 260 of about 29,558 (298)

Immunoglobulin Structure: Amino Terminal Sequences of Kappa Chains from Genetically Similar Mice (BALB/c)

Science, 1970
The amino terminal portion of 20 kappa chains from the highly inbred BALB/c mouse has been examined on an automatic protein sequencer. These proteins can be divided into at least nine groups (subgroups) based on sequence patterns which are so distinct that each subgroup is probably encoded by at least one germ-line gene.
Hood, L E, Potter, M, Kean, D J
exaly   +4 more sources

Kappa-Chain Deficiency

New England Journal of Medicine, 1976
Since kappa-chain deficiency is an unusual condition, we studied the clinical and laboratory findings in a patient with this deficiency. The patient had cystic fibrosis with concurrent malabsorption, diabetes mellitus and IgA deficiency. The serum levels of IgM and IgG were 0.85 and 7.22 mg per milliliter, respectively.
B J, Zegers   +7 more
openaire   +2 more sources

Monoclonal Antibodies Against Rat Immunoglobulin Kappa Chains

Hybridoma, 1982
Monoclonal antibodies directed against rat kappa light chains have been generated by immunizing SJL/J mice with soluble rat immunoglobulin, followed by fusion of immune spleen cells with the P3-X63-Ag8 myeloma cell line. Monoclonal antibodies from three of these hybridoma cell lines, MAR 18.5, 80.2, and 103.6, have been extensively characterized.
L L, Lanier   +4 more
openaire   +2 more sources

Age-related isomerization of Asp in human immunoglobulin G kappa chain

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2020
Isomerization of aspartate (Asp) is a common non-enzymatic posttranslational modification. Isomerized residues accumulate in proteins associated with age-related human disorders such as cataract and are well known to affect protein structure and function. We previously detected d-Asp-containing peptides in human serum.
Seongmin, Ha   +2 more
openaire   +2 more sources

Isolation of messenger RNA for an immunoglobulin kappa chain and enumeration of the genes for the constant region of kappa chain in the mouse

Journal of Molecular Biology, 1974
Abstract The messenger RNA for an immunoglobulin light (kappa) chain was isolated from the mouse myeloma MOPC41 and shown to be almost twofold longer than necessary to code for its protein product. DNA complementary to the mRNA was synthesized with the RNA-directed DNA polymerase of Rous sarcoma virus.
Stavnezer, Janet   +3 more
openaire   +3 more sources

Two Structurally Distinct Classes of Kappa-chains in Human Immunoglobulins

Nature, 1967
THE general structural features of the various types of immunoglobulins are known and the details of the primary structure are gradually being filled in. A characteristic feature of the immune response, however, is its specificity and here the data have not been sufficient to reveal the structural basis of the specificity and even less the underlying ...
H D, Niall, P, Edman
openaire   +2 more sources

Single light chain subclass (kappa chain) immunoglobulin deposition in glomerulonephritis

Human Pathology, 1985
Renal glomerular disease characterized by the deposition of immunoglobulin light chains or monoclonal immunoglobulins was demonstrated by immunofluorescence microscopy in 11 patients. The most common histopathologic findings were those of mesangiocapillary glomerulonephritis, but considerable variability was observed.
C E, Alpers   +3 more
openaire   +2 more sources

The organization of immunoglobulin variable kappa chain genes on mouse chromosome 6

Immunogenetics, 1986
One mouse with a known recombination (NAK) at the Igk locus on chromosome 6 and two new recombinants [B6.PL (75NS) and B6.PL (85NS)] were examined using a series of probes, each of which is specific for a set of immunoglobulin (Ig) Vk genes. Under high stringency conditions, each probe detects from 1 to 19 Bam HI restriction endonuclease fragments ...
L A, D'Hoostelaere, D M, Gibson
openaire   +2 more sources

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