Immunoglobulin light chain amyloidosis diagnosis and treatment algorithm 2021 [PDF]
Blood Cancer Journal, 2021 Immunoglobulin light chain amyloidosis (AL) commonly presents with nephrotic range proteinuria, heart failure with preserved ejection fraction, nondiabetic peripheral neuropathy, unexplained hepatomegaly or diarrhea, and should be considered in patients ...
M. Hasib Sidiqi, Morie A. Gertz
doaj +6 more sources
Localized Immunoglobulin Light-Chain Amyloidosis of the Ulnar Nerve [PDF]
Case Reports in Neurology, 2021 Amyloidosis is a disorder caused by extracellular tissue deposition of insoluble fibrils. Amyloidosis can be divided into systemic or localized disease. Primary systemic amyloidosis is a multisystem disease caused by the deposition of amyloid in various ...
Shinsuke Morisaki +5 more
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Suggestive Diagnostic Process in a Case of Multiple Myeloma with Gastrointestinal Immunoglobulin Light-Chain Amyloidosis Accompanied by Protein-Losing Enteropathy [PDF]
Case Reports in Gastrointestinal Medicine, 2021 Multiple myeloma is a type of plasma cell neoplasm that produces monoclonal immunoglobulin. Multiple myeloma is known to cause immunoglobulin light-chain (AL) amyloidosis, which frequently involves the kidney and heart.
Katsuya Endo +15 more
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Immunoglobulin light chain amyloidosis presenting as Budd-Chiari syndrome. [PDF]
Hepatol Forum, 2021 Ozercan M +5 more
europepmc +5 more sources
Exploiting endogenous and therapy-induced apoptotic vulnerabilities in immunoglobulin light chain amyloidosis with BH3 mimetics [PDF]
Nature Communications, 2022 Immunoglobulin light chain amyloidosis is a lethal hematologic disorder driven by clonal plasma cells producing abnormal light chains that damage healthy tissues. Fraser et al.
Cameron S. Fraser +14 more
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Nature Communications, 2019 Immunoglobulin Light Chain Amyloidosis (AL) is the most common systemic amyloidosis occurring in Western countries. Here the authors present the 4.0 Å cryo-EM structure of light chain AL55 fibrils that were isolated from the heart of an AL systemic ...
Paolo Swuec +13 more
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Safety and efficacy of teclistamab in systemic immunoglobulin light chain amyloidosis. [PDF]
Blood Cancer J, 2023 Chakraborty R +5 more
europepmc +3 more sources
Recent advances in understanding and treating immunoglobulin light chain amyloidosis [version 1; referees: 2 approved] [PDF]
F1000Research, 2018 Immunoglobulin (Ig) light chain (AL) amyloidosis is a clonal plasma cell disorder characterized by misfolded Ig light chain deposition in vital organs of the body, resulting in proteotoxicity and organ dysfunction.
Talha Badar +2 more
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Budd-Chiari Syndrome as the Presenting Feature of Systemic Immunoglobulin Light Chain Amyloidosis. [PDF]
Eur J Case Rep Intern MedMiranda JL +6 more
europepmc +3 more sources
Oxidative damage in immunoglobulin light chain and transthyretin cardiac amyloidosis – a closer look
Redox Experimental MedicineHeart failure is a progressive disease, representing a growing cause of morbidity, hospitalization, and mortality. An increasingly common type of heart failure with preserved ejection fraction (HFpEF) is an immunoglobulin light chain and transthyretin ...
Elena Cavallone +5 more
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