Immunoglobulin Light Chain Amyloidosis: Diagnosis and Risk Assessment. [PDF]
J Natl Compr Canc Netw, 2023 Immunoglobulin light chain (AL) amyloidosis is a clonal plasma cell disorder with multiple clinical presentations. The diagnosis of AL amyloidosis requires a high index of suspicion, making a delay in diagnosis common, which contributes to the high early mortality seen in this disease.
Zanwar S, Gertz MA, Muchtar E.
europepmc +5 more sources
Recent advances in understanding and treating immunoglobulin light chain amyloidosis [version 1; referees: 2 approved] [PDF]
F1000Research, 2018 Immunoglobulin (Ig) light chain (AL) amyloidosis is a clonal plasma cell disorder characterized by misfolded Ig light chain deposition in vital organs of the body, resulting in proteotoxicity and organ dysfunction.
Talha Badar +2 more
doaj +6 more sources
Hereditary systemic immunoglobulin light-chain amyloidosis [PDF]
Blood, 2015 Several members of a family died from renal failure as a result of systemic amyloidosis. Extensive studies to detect previously documented gene mutations associated with amyloidosis failed to identify a causative factor.
Benson, Merrill D. +2 more
core +5 more sources
IgM-Related Immunoglobulin Light Chain (AL) Amyloidosis
Hemato, 2022 Waldenström macroglobulinemia (WM) is a rare lymphoplasmacytic disorder characterized by an IgM paraprotein. The clinical presentation of WM varies and can include common manifestations such as anemia and hyperviscosity, in addition to less common ...
Shayna Sarosiek +3 more
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Amyloid cranial polyneuropathy: A rare neurological presentation of immunoglobulin light‐chain amyloidosis [PDF]
Aging Medicine, 2021 Amyloidosis, a disease with extracellular tissue deposition of fibrils, results in clinical manifestations based on deposition of these fibrils in multiple organ systems.
Abhinav Agarwal +4 more
doaj +2 more sources
Systemic immunoglobulin light chain amyloidosis [PDF]
Nature Reviews Disease Primers, 2018 Systemic immunoglobulin light chain amyloidosis is a protein misfolding disease caused by the conversion of immunoglobulin light chains from their soluble functional states into highly organized amyloid fibrillar aggregates that lead to organ dysfunction.
Merlini G. +6 more
+8 more sources
Oxidative damage in immunoglobulin light chain and transthyretin cardiac amyloidosis – a closer look
Redox Experimental MedicineHeart failure is a progressive disease, representing a growing cause of morbidity, hospitalization, and mortality. An increasingly common type of heart failure with preserved ejection fraction (HFpEF) is an immunoglobulin light chain and transthyretin ...
Elena Cavallone +5 more
doaj +2 more sources
A prospective study of nutritional status in immunoglobulin light chain amyloidosis
Haematologica, 2013 Weight loss is common in systemic immunoglobulin light chain amyloidosis but there are limited data on the impact of nutritional status on outcome.
Prayman T. Sattianayagam +12 more
doaj +4 more sources
T cell landscape and dynamics in immunoglobulin light chain amyloidosis before and after daratumumab-based therapy. [PDF]
Clin Transl Med, 2021 Wang Y +12 more
europepmc +3 more sources
Immunoglobulin light chain amyloidosis and the kidney [PDF]
Kidney International, 2002 Immunoglobulin light chain amyloidosis and the kidney. Amyloidosis (AL) is a common cause of nephrotic syndrome in nondiabetic, nonhypertensive adults. All adult patients with nephrotic syndrome should have immunofixation of serum and urine as a screen.
Morie A. Gertz +2 more
openalex +4 more sources