Light‐chain amyloid myopathy isolated to skeletal muscles: A case report
Clinical Case Reports, 2020 Isolated amyloidosis, especially of amyloid light‐chain type, is an infrequent disease. Systemic chemotherapy for light‐chain amyloidosis isolated to skeletal muscles plays a key role to reduce clonal plasma cells producing aberrant immunoglobulin.
Toshihiro Matsukawa +5 more
doaj +1 more source
Amyloid light-chain deposition in a schwannoma
Interdisciplinary Neurosurgery, 2021 Systemic amyloid light-chain amyloidosis is a protein misfolding disorder characterized by extracellular deposition of amyloid fibrils derived from abnormal clonal immunoglobulin light chains in various organ systems.
Megan M. Jack +6 more
doaj +1 more source
FOCUSED REVIEW ON NUTRITIONAL STATUS OF PATIENTS WITH IMMUNOGLOBULIN LIGHT CHAIN AMYLOIDOSIS
medRxiv, 2021 Background: Immunoglobulin light chain (AL) amyloidosis is a complex disease marked by a poor clinical portrait and prognosis generally leading to organ dysfunction and shortened survival.
S. Grigoletti +6 more
semanticscholar +1 more source
Localized Immunoglobulin Light-Chain Amyloidosis of the Ulnar Nerve
Case Reports in Neurology, 2021 Amyloidosis is a disorder caused by extracellular tissue deposition of insoluble fibrils. Amyloidosis can be divided into systemic or localized disease. Primary systemic amyloidosis is a multisystem disease caused by the deposition of amyloid in various ...
Shinsuke Morisaki +5 more
doaj +1 more source
Three-dimensional structure of an immunoglobulin light-chain dimer with amyloidogenic properties [PDF]
, 2002 The X-ray structure of an immunoglobulin light-chain dimer isolated from the urine as a 'Bence-Jones protein' from a patient with multiple myeloma and amyloidosis (Sea) was determined at 1.94 Angstrom resolution and refined to R and R-free factors of 0 ...
Bourne, P. C. +10 more
core +2 more sources
Immunoglobulin light chain amyloidosis
memo - Magazine of European Medical Oncology, 2021 Immunoglobulin light chain (AL) amyloidosis is a rare and underdiagnosed life-threatening systemic disease, primarily caused by insoluble depositions of misfolded monoclonal light chains.
H. Agis, M. Krauth
semanticscholar +1 more source
99mTc-DPD scintigraphy in immunoglobulin light chain (AL) cardiac amyloidosis
European Heart Journal-Cardiovascular Imaging, 2021 Aims Technetium-99m-labelled 3,3-diphosphono-1,2-propanodicarboxylic acid (99mTc-DPD scintigraphy) is recognized as highly accurate for the non-invasive diagnosis of transthyretin (ATTR) cardiac amyloidosis (CA).
C. Quarta +15 more
semanticscholar +1 more source
A common beta-sheet architecture underlies in vitro and in vivo beta(2)-microglobulin amyloid fibrils [PDF]
, 2008 Misfolding and aggregation of normally soluble proteins into amyloid fibrils and their deposition and accumulation underlies a variety of clinically significant diseases.
Jahn, T.R., Radford, S.E., Tennent, G.A.
core +2 more sources
Cardiac Amyloidosis – An Underdiagnosed Cause of Heart Failure with Preserved Ejection Fraction – Updated Diagnosis and Treatment Options [PDF]
Romanian Journal of Cardiology, 2021 Cardiac amyloidosis (CA) still represents a frequently missed cause of heart failure with preserved ejection fraction (HFpEF). In the light of many new and effective therapies for immunoglobulin light chain amyloidosis (AL) and for transthyretin ...
Roxana Cristina RIMBAS +3 more
doaj +1 more source
Monoclonal gammopathy of renal significance: Diagnostic workup [PDF]
, 2017 The clinical spectrum of diseases associated with monoclonal gammopathies is wide and they are most commonly the consequence of renal deposition of monoclonal immunoglobulin or its components.
Cabrita, A. +5 more
core +1 more source