Results 221 to 230 of about 163,653 (347)

Shared molecular profiles of anti-PL12 autoantibodies in anti-synthetase syndrome. [PDF]

Rheumatology (Oxford)
Ali SB, Troelnikov A, Amour B, Hender L, Beroukas D, Chataway T, Limaye V, Gordon TP, Wang JJ.   +8 more
europepmc   +1 more source

Structure and multiplicity of genes for the human immunoglobulin heavy chain variable region.

, 1980
G. Matthyssens, Terence H. Rabbitts
openalex   +2 more sources

Tetrastigma Hemsleyanum Polysaccharide Suppresses Triple‐Negative Breast Cancer by Disrupting the Hippo‐YAP/TEAD4‐PDIA4 Axis and Endoplasmic Reticulum Stress Adaptation

Advanced Science, EarlyView.
ABSTRACT Triple‐negative breast cancer (TNBC) exhibits addiction to chronic endoplasmic reticulum (ER) stress, which sustains an aggressive metastatic phenotype through activation of the unfolded protein response (UPR). Here, we identify a previously unrecognized “ER‐stress addiction” axis in which the Hippo pathway effector TEAD4 directly ...
Yini Shang, Wentao Si, Youxue Zhang, Jialin Liu, Huaixi Zhang, Yafei Li, Hongmeng Su, Wei Jiang, Zhishan Ding, Lihong Wang   +9 more
wiley   +1 more source

Gatm ablation disrupts spermatogenesis by impairing ribosome biogenesis and coupling defective steroid biosynthesis to immunoglobulin silencing. [PDF]

Front Cell Dev Biol
Li S, Chen L, Zhu M, Yang L, Wu H, Zhou X.   +5 more
europepmc   +1 more source

Rearranged immunoglobulin heavy chain variable region (VH) pseudogene that deletes the second complementarity-determining region.

, 1984
Naoki Takahashi, Takafumi Noma, Tasuku Honjo   +2 more
openalex   +2 more sources

Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma with Immunoglobulin Heavy Chain Variable-Region Gene Somatic Hypermutation

, 2020
National Cancer Institute
openalex   +1 more source

SOMATIC MUTATION (SM) OF HUMAN IMMUNOGLOBULIN (Ig) HEAVY CHAIN VARIABLE (V) REGION GENES TARGETS COMPLEMENTARITY DETERMINING REGIONS (CDR) IN THE ABSENCE OF ANTIGEN (Ag) SELECTION. • 74 [PDF]

, 1996
William S. Varade, Jennifer A. Jones, Paul D. Kingsley, Richard A. Insel   +3 more
openalex   +1 more source

Myeloid‐Derived Grancalcin Promotes Periodontal Inflammation and Pathological Bone Remodeling in Periodontitis

Advanced Science, EarlyView.
Grancalcin (GCA), a myeloid‐derived protein, is enriched in gingival tissues of periodontitis patients and mouse models. Through interactions with CD44 and activation of MYH9, GCA promotes NF‐κB signaling and exacerbates periodontal inflammation and bone loss.
Min Zhou, Yao Xiao, Ziyue Xu, Chengyu Yang, Jiang Li, Ya Liu, Ping Yin   +6 more
wiley   +1 more source

Intravenous Immunoglobulin Treatment in Patients With Streptococcal Toxic Shock Syndrome in Southern Sweden: A Retrospective Population-Based Study. [PDF]

Open Forum Infect Dis
Wullt O, Utbult C, Carlson E, Ljungquist O, Sunnerhagen T, Bläckberg A, Torisson G.   +6 more
europepmc   +1 more source

SMAD4 Palmitoylation Drives a Metabolic‐Transcriptional Circuit to Promote Tumorigenesis and Confers Radiosensitivity in Pancreatic Cancer

Advanced Science, EarlyView.
This study identifies palmitoylation as a novel regulatory modification of SMAD4, mediated by ZDHHC22/APT2. It activates fatty acid synthesis, creating a self‐reinforcing SMAD4–FASN–palmitate feedback loop that drives pancreatic cancer growth and enhances radiotherapy sensitivity.
Yang Wang, Shan Zhang, Junping Bai, Xiaobing Li, Yi Han, Min Ji, Chongyi Jiang, Xiaobei Ge, Tianyu Yu, Yongying Hou, Jun Zhang, Wangting Li, Yiran Song, Jiaying Cai, Yingqun Zhou, Liwei An, Feng Wang   +16 more
wiley   +1 more source