Results 281 to 290 of about 326,951 (318)

Immunoglobulin variable region sequences of humanmonoclonal anti-DNA, antibodies

Seminars in Arthritis and Rheumatism, 1998
Anti-DNA antibodies are believed to be important in the pathogenesis of systemic lupus erythematosus (SLE). Antibodies that bind specifically and with high affinity to dsDNA are most closely involved in tissue damage. Analysis of the sequences of the variable regions of human monoclonal anti-DNA antibodies is useful in defining the structural features ...
A, Rahman, D S, Latchman, D A, Isenberg
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Heavy Chain Variable Region Allotypic Sub-Specificities of Rabbit Immunoglobulins

The Journal of Immunology, 1976
Abstract Four anti-a1 Ab subpopulations were isolated from an anti-a1 antiserum by sequential immunoadsorption chromatography. These four anti-a1 Ab subpopulations were differentially bound by two “limited heterogeneity” Abs having different components of the a1 allotypic specificity.
Wayne J Horng, Katherine L Knight, Sheldon Dray   +2 more
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Evolution of unblocked immunoglobulin variable regions in Primates

Journal of Human Evolution, 1972
Abstract Amino-terminal amino acid sequences of unblocked heavy and light chains of immunoglobulin G molecules from adult normal pigtailed monkey, rhesus monkey and human were determined by Edman Degradation using an Automatic Protein Sequencer. These sequences are similar among the three primate species.
An-Chuan Wang, H.Hugh Fudenberg
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Heating of immunoglobulins for immunoblot analysis destroys variable region antigenicity

Journal of Immunological Methods, 1986
The antigenicity of rabbit immunoglobulin heavy chain variable region allotypes was examined by immunoblotting after sodium dodecyl sulfate-polyacrylamide gel electrophoresis. The standard method of sample preparation resulted in a total loss of immunoreactivity with anti-allotype antibody due to heating of the samples prior to their electrophoresis ...
V H, Van Cleave, D W, Metzger
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Functional and Structural Implications of Variable Region Immunoglobulin Dynamic States

Immunological Investigations, 1988
The consequence of multiple conformational states in the immunoglobulin variable region are considered. Bound ligand is viewed as a stabilizer of one conformer from a series of non-liganded conformers. Kinetic, equilibrium, thermodynamic and crystal formation information are used as supporting evidence for a unique conformer which is the crystallizable
E W, Voss, M A, Dombrink-Kurtzman, S D, Miklasz   +2 more
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Expression of Immunoglobulin Variable Region Antigens on Mouse B Lymphocytes

The Journal of Immunology, 1979
Abstract Rabbit antibodies prepared against two purified 7S BALB/c myeloma proteins, A2 (γ1, κ) and MOPC 195 (γ2b, κ), and solid-phase absorbed so as to contain only anti-heavy (H) chain specificities bound to 32 to 35% of C57BL/6 lymph node lymphocytes (about 80% of the B lymphocytes).
Stanislawski, M, Mitard, M
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Rapid PCR-Cloning of Full-Length Mouse Immunoglobulin Variable Regions

Nature Biotechnology, 1991
The humanisation of a mouse MAb depends on the cloning and sequencing of immunoglobulin variable regions from the MAb under investigation. We have adpated an earlier method used for cloning and sequencing entire human variable regions and designed a collection of redundant primers which enable the rapid and efficient PCR-cloning of mouse immunoglobulin
S T, Jones, M M, Bendig
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Polymorphism of the human immunoglobulin variable region segment V1-4.1

Immunogenetics, 1993
Department of Medical Chemistry, Faculty of medicine, Kyoto University, Sakyo-ku, Kyoto 606, Japan 2 Center for Molecular Biology and Genetics, Kyoto University, Sakyo-ku, Kyoto 606, Japan 3 Second Department of Internal Medicine, Faculty of Medicine, Kyoto University, Sakyo-ku, Kyoto 606, Japan 4 Department of Clinical Immunology, Karolinska Institute
E K, Shin, F, Matsuda, S, Ozaki, S, Kumagai, O, Olerup, H, Ström, I, Melchers, T, Honjo   +7 more
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Chapter 3 Genes encoding the immunoglobulin variable regions

1987
Publisher Summary Studies of antibody structure have shown that the great diversity of antigen combining sites is due to the highly variable amino-terminal protein sequences of both light and heavy chain polypeptides. The observation that antibody polypeptide sequences have variable and constant regions presented geneticists with a paradox: how did ...
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N-linked glycosylation of the immunoglobulin variable region

Proceedings of the National Academy of Sciences of the United States of America, 2018
N-glycosylation sites are introduced at positions in which glycans can affect antigen binding as a result of a specific clustering of progenitor glycosylation sites in the germline sequences of variable domain genes. By analyzing multiple human monoclonal and polyclonal (auto)antibody responses, we subsequently show that this process is subject to ...
van de Bovenkamp, Fleur S., Derksen, Ninotska I. L., Ooijevaar-de Heer, Pleuni, van Schie, Karin A., Kruithof, Simone, Berkowska, Magdalena A., van der Schoot, C. Ellen, Ijspeert, Hanna, van der Burg, Mirjam, Gils, Ann, Hafkenscheid, Lise, Toes, René E. M., Rombouts, Yoann, Plomp, Rosina, Wuhrer, Manfred, van Ham, S. Marieke, Vidarsson, Gestur, Rispens, Theo   +17 more
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