Results 51 to 60 of about 291,810 (337)

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Gestational Pemphigoid—From Molecular Mechanisms to Clinical Outcomes: A Case Report and Review of Literature

Life
Gestational pemphigoid is a rare, autoimmune, subepidermal bullous disease with an incidence of 1 in 50,000 pregnancies, displaying itself through pruritic erythema and urticarial papules and plaques that evolve into tense bullae.
Miruna Ioana Cristescu, Cristina Violeta Tutunaru, Anca Panaitescu, Vlad Mihai Voiculescu   +3 more
doaj   +1 more source

FUNCTIONAL ACTIVITY OF MURINE B CELL: A ROLE OF MICROENVIRONMENT

Медицинская иммунология, 2014
. To study influence of microenvironment upon functional activity of B cells, we used experimental models of adoptive cell transfer from CBA to congenic CBA/N mice lacking CD5+ B-1 cells, and cocultivation of CBA/N splenocytes with spleen, or peritoneal ...
I. N. Dyakov, I. V. Grigoriev, E. V. Sidorova, I. N. Chernyshova   +3 more
doaj   +1 more source

Anisotropic coarse-grained statistical potentials improve the ability to identify native-like protein structures [PDF]

, 2003
We present a new method to extract distance and orientation dependent potentials between amino acid side chains using a database of protein structures and the standard Boltzmann device.
Bagci, Bahar, Banavar, Ben-Naim, Berman, Betancourt, D. Thirumalai, Dima, Duan, Eisenberg, Ferrara, Fiebig, Gatchell, Gay, Godzik, Hendlich, Humphrey, J. E. Straub, Keskin, Kussell, Lee, Lee, Lee, Levitt, Liwo, Liwo, Liwo, Meller, Meller, Miyazawa, N.-V. Buchete, Plaxco, Richards, Samudrala, Samudrala, Shen, Sippl, Sippl, Soyer, Steinhardt, Tanaka, ten Wolde, ten Wolde, Thomas, Tobi, Tobi, Tsai, van Duijneveldt, Vendruscolo, Vorobjev, Vorobjev   +50 more
core   +2 more sources

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Human body resistance dynamics in the post-covid period

Инфекция и иммунитет
The issue of the state of specific and nonspecific resistance in the post-COVID period and the possible consequences of COVID-19 remains poorly understood.
Ekaterina V. Zhdanova, E. V. Rubtsova, E. G. Kostolomova   +2 more
doaj   +1 more source

PATTERN OF LOCAL IMMUNE ALTERATIONS IN THE PATIENTS WITH CHRONIC ADENOIDITIS, AND AN OPPORTUNITY OF THEIR CORRECTION WITH IMUNOFAN

Медицинская иммунология, 2014
. The issue of chronic adenoiditis, due to its medical and social significance, is in focus of attention for otolaryngologists, pediatricians, immunologists.
R. N. Kuznetsova, K. A. Syssoev, V. V. Lebedev, A. V. Tutelian, Areg A. Totolian   +4 more
doaj   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Mass spectrometry-based analysis of rheumatoid factor

Frontiers in Immunology
IntroductionRheumatoid factor (RF) are autoantibodies that are found in approximately two thirds of patients with rheumatoid arthritis, a chronic autoimmune disease characterized by potentially destructive inflammation of the joints.
Jonas De Leeuw, Jonas De Leeuw, Birthe Michiels, Birthe Michiels, Rita Derua, Rita Derua, Tom Dehaemers, Tom Dehaemers, Doreen Dillaerts, Doreen Dillaerts, Maaike Cockx, Maaike Cockx, Maaike Cockx, Glynis Frans, Glynis Frans, Sebastien Christian Carpentier, Patrick Verschueren, Patrick Verschueren, Xavier Bossuyt, Xavier Bossuyt   +19 more
doaj   +1 more source

Posterior Reversible Encephalopathy Syndrome in Guillain-Barré Syndrome: Just a Problem of Immunoglobulins? Controversy From Two Atypical Case Reports

Frontiers in Neurology, 2022
BackgroundPosterior reversible encephalopathy syndrome (PRES), reversible cerebral vasoconstriction syndrome (RCVS), or the coexistence of these two entities shares similar risk factors and clinical features.
Enrico Belgrado, Ilaria Del Negro, Ilaria Del Negro, Daniele Bagatto, Simone Lorenzut, Giovanni Merlino, Gian L. Gigli, Gian L. Gigli, Mariarosaria Valente, Mariarosaria Valente   +9 more
doaj   +1 more source