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THE UNLABELED ANTIBODY ENZYME METHOD OF IMMUNOHISTOCHEMISTRY PREPARATION AND PROPERTIES OF SOLUBLE ANTIGEN-ANTIBODY COMPLEX (HORSERADISH PEROXIDASE-ANTIHORSERADISH PEROXIDASE) AND ITS USE IN IDENTIFICATION OF SPIROCHETES [PDF]

Journal of Histochemistry and Cytochemistry, 1970
Ludwig A. Sternberger, Paul H. Hardy, John J. Cuculis, Howard G. Meyer   +3 more
openalex   +2 more sources

Basics of Immunohistochemistry [PDF]

Journal of Investigative Dermatology, 2015
INTRODUCTION Immunohistochemistry (IHC) is a powerful method for localizing specific antigens in formalin-fixed, paraffin-embedded (FFPE) tissues based on antigen–antibody interaction (Taylor and Burns, 1974). The technique is widely used in dermatologic diagnostics and research, and its applications continue to be extended because of its ease of use ...
Johannes S. Kern, Vivien Schacht
openaire   +3 more sources

p53 immunohistochemistry in endometrial cancer: clinical and molecular correlates in the PORTEC-3 trial

Modern Pathology, 2022
Standard molecular classification of endometrial cancers (EC) is now endorsed by the WHO and identifies p53-abnormal (p53abn) EC as the subgroup with the poorest prognosis and the most likely to benefit from adjuvant chemo(radio)therapy.
L. Vermij, A. Léon-Castillo, Naveena Singh, M. Powell, R. Edmondson, C. Genestie, P. Khaw, J. Pyman, C. McLachlin, P. Ghatage, S. D. de Boer, H. Nijman, V. Smit, E. Crosbie, A. Leary, C. Creutzberg, N. Horeweg, T. Bosse, N. S. M. C. L. T. V. T. H. B. M. J. R. A. H. W. M. M. Horeweg de Boer Creutzberg Bosse Smit Kroep Nout N, N. Horeweg, S. D. de Boer, C. Creutzberg, T. Bosse, V. Smit, J. Kroep, R. Nout, H. Nijman, M. de Bruyn, M. Powell, N. Singh, H. Kitchener, E. Crosbie, R. Edmondson, D. Church, A. Leary, L. Mileshkin, P. Pollock, H. Mackay   +37 more
semanticscholar   +1 more source

PD-L1 testing by immunohistochemistry in immuno-oncology

Bosnian Journal of Basic Medical Sciences, 2022
Immunotherapy, based on immune checkpoint inhibitors (ICIs) targeting the programmed cell death ligand 1 (PD-L1) and/or programmed death receptor 1 (PD-1), has substantially improved the outcomes of patients with various cancers.
S. Vranić, Z. Gatalica
semanticscholar   +1 more source

Overview of multiplex immunohistochemistry/immunofluorescence techniques in the era of cancer immunotherapy

Cancer Communications, 2020
Conventional immunohistochemistry (IHC) is a widely used diagnostic technique in tissue pathology. However, this technique is associated with a number of limitations, including high inter‐observer variability and the capacity to label only one marker per
W. Tan, S. N. Nerurkar, H. Cai, Harry Ho Man Ng, Duo-qing Wu, Yu Ting Felicia Wee, J. Lim, J. Yeong, T. Lim   +8 more
semanticscholar   +1 more source

Basic immunohistochemistry for lymphoma diagnosis

Blood Research, 2022
Immunohistochemistry is a technique that uses antigen-antibody interactions to detect specific proteins in cells. This technique has several essential applications in lymphoma diagnosis, including identifying the cell lineage and phase of maturation ...
Junhun Cho
semanticscholar   +1 more source

Immunohistochemistry [PDF]

WormBook, 2006
Immunohistochemistry allows specific proteins to be visualized while retaining cellular or tissue structure. Sensitivity of the technique has improved over the years from a single layer of labeled antibody to amplified, labeled polymer-based systems, which enable low levels of antigen to be detected in different types of tissue preparation.
openaire   +4 more sources

Correlation of 68Ga-FAPi-46 PET Biodistribution with FAP Expression by Immunohistochemistry in Patients with Solid Cancers: Interim Analysis of a Prospective Translational Exploratory Study

Journal of Nuclear Medicine, 2021
Visual Abstract Fibroblast activation protein (FAP)–expressing cancer-associated fibroblasts confer treatment resistance and promote metastasis and immunosuppression.
Christine E. Mona, M. Benz, Firas Hikmat, T. Grogan, K. Lückerath, Aria A. Razmaria, Rana Riahi, R. Slavik, M. Girgis, G. Carlucci, K. Kelly, S. French, J. Czernin, D. Dawson, J. Calais   +14 more
semanticscholar   +1 more source

Comparison of microsatellite instability detection by immunohistochemistry and molecular techniques in colorectal and endometrial cancer

Scientific Reports, 2021
DNA mismatch repair deficiency (dMMR) testing is crucial for diagnosing Lynch syndrome and detection of microsatellite unstable (MSI) tumors eligible for immunotherapy.
F. Dedeurwaerdere, K. Claes, J. van Dorpe, I. Rottiers, Joni Van der Meulen, J. Breyne, Koen Swaerts, G. Martens   +7 more
semanticscholar   +1 more source

The novel MAPT mutation K298E:mechanisms of mutant tau toxicity, brain pathology and tau expression in induced fibroblast-derived neurons [PDF]

, 2013
Frontotemporal lobar degeneration (FTLD) consists of a group of neurodegenerative diseases characterized by behavioural and executive impairment, language disorders and motor dysfunction.
Calo, Laura, Goedert, Michel, Holton, Janice L., Iovino, Mariangela, Lashley, Tammaryn, Lund University., Lund University., Lund University., Muqit, Miratul M. K., Parmar, Malin,, Pfisterer, Ulrich,, Revesz, Tamas, Spillantini, Maria Grazia, Swingler, Robert J., Treacy, Rebecca   +14 more
core   +3 more sources