Impact of decitabine on immunohistochemistry expression of the putative tumor suppressor genes FHIT, WWOX, FUS1 and PTEN in clinical tumor samples. [PDF]
, 2014 BackgroundSince tumor suppressor gene function may be lost through hypermethylation, we assessed whether the demethylating agent decitabine could increase tumor suppressor gene expression clinically.
Aldaz, Marcelo +8 more
core +3 more sources
Ensuring accurate stain reproduction in deep generative networks for virtual immunohistochemistry [PDF]
arXiv, 2022 Immunohistochemistry is a valuable diagnostic tool for cancer pathology. However, it requires specialist labs and equipment, is time-intensive, and is difficult to reproduce. Consequently, a long term aim is to provide a digital method of recreating physical immunohistochemical stains. Generative Adversarial Networks have become exceedingly advanced at
arxiv
Automated Segmentation of Cells with IHC Membrane Staining [PDF]
, 2011 This study presents a fully automated membrane segmentation technique for immunohistochemical tissue images with membrane staining, which is a critical task in computerized immunohistochemistry (IHC).
Acquaviva, Andrea +3 more
core +1 more source
Application of immunohistochemistry in diagnosis and management of malignant mesothelioma
Translational Lung Cancer Research, 2020 Immunohistochemistry plays an indispensable role in accurate diagnosis of malignant mesothelioma, particularly in morphologically challenging cases and in biopsy and cytology specimens, where tumor architecture is difficult or impossible to evaluate ...
David B. Chapel +3 more
semanticscholar +1 more source
Image Translation Based Nuclei Segmentation for Immunohistochemistry Images [PDF]
arXiv, 2022 Numerous deep learning based methods have been developed for nuclei segmentation for H&E images and have achieved close to human performance. However, direct application of such methods to another modality of images, such as Immunohistochemistry (IHC) images, may not achieve satisfactory performance. Thus, we developed a Generative Adversarial Network (
arxiv
Testicular degeneration and infertility following arbovirus infection [PDF]
, 2018 Arboviruses can cause a variety of clinical signs including febrile illness, arthritis, encephalitis and hemorrhagic fever. The recent Zika epidemic highlighted the possibility that arboviruses may also negatively affect the male reproductive tract.
Dattena, Maria +11 more
core +1 more source
CD45 Immunohistochemistry in Mouse Kidney
Bio-Protocol, 2021 CD45 is a pan-leukocyte marker, and CD45 stain is widely used to determine the extent of inflammatory cell infiltration and its association with tissue injury.
Shirong Zheng, Paul Epstein
doaj +1 more source
Automated Volume Corrected Mitotic Index Calculation Through Annotation-Free Deep Learning using Immunohistochemistry as Reference Standard [PDF]
arXiv, 2023 The volume-corrected mitotic index (M/V-Index) was shown to provide prognostic value in invasive breast carcinomas. However, despite its prognostic significance, it is not established as the standard method for assessing aggressive biological behaviour, due to the high additional workload associated with determining the epithelial proportion.
arxiv
Diagnosis of anaplastic large-cell lymphoma in a dog using CD30 immunohistochemistry [PDF]
, 2018 Anaplastic large-cell lymphoma or null-cell lymphoma is a clinical entity reported in people, classified according to the unique appearance of large pleomorphic cells that express CD30.
Garden, O A +7 more
core +1 more source
Developing Monoclonal Antibodies for Immunohistochemistry
Cells, 2022 The experiences of a laboratory which pioneered the application of monoclonal antibodies to diagnostic histochemistry is described. This was achieved in four key steps: (1) Monoclonal antibodies were successfully produced to replace the difficult-to ...
Jacqueline Cordell
doaj +1 more source