Results 1 to 10 of about 3,331 (204)

A novel immunoinformatic approach for design and evaluation of heptavalent multiepitope foot-and-mouth disease virus vaccine [PDF]

BMC Veterinary Research
Background Foot-and-mouth disease virus (FMDV) vaccine development can be a laborious task due to the existence of various serotypes and lineages and its quasi-species nature.
Mostafa R. Zaher, Mohamed H. El-Husseiny, Naglaa M. Hagag, Azza M. El-Amir, Mohamed E. El Zowalaty, Reham H. Tammam   +5 more
doaj   +3 more sources

Immunoinformatic Analysis of Human Thyroglobulin [PDF]

Cybernetics and Information Technologies, 2020
The AutoImmune ThyroiDitis (AITD), known as Hashimoto’s disease, is a chronic autoimmune thyroid disease progressively developed to hypothyroidism. The AITD is characterized by the formation of autoantibodies targeting two specific thyroid antigens ...
Doytchinova Irini, Tchorbanov Andrey, Ivanov Stefan   +2 more
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An In Silico Deep Learning Approach to Multi-Epitope Vaccine Design: A Hepatitis E Virus Case Study

Vaccines, 2023
Hepatitis E Virus (HEV) is a major cause of acute and chronic hepatitis. The severity of HEV infection increases manyfold in pregnant women and immunocompromised patients.
Aqsa Ikram, Badr Alzahrani, Tahreem Zaheer, Sobia Sattar, Sidra Rasheed, Muhammad Aurangzeb, Yasmeen Ishaq   +6 more
doaj   +1 more source

Design of a Multi-Epitope Vaccine against Tropheryma whipplei Using Immunoinformatics and Molecular Dynamics Simulation Techniques

Vaccines, 2022
Whipple’s disease is caused by T. whipplei, a Gram-positive pathogenic bacterium. It is considered a persistent infection affecting various organs, more likely to infect males.
Thamer H. Albekairi, Abdulrahman Alshammari, Metab Alharbi, Amal F. Alshammary, Muhammad Tahir ul Qamar, Tasneem Anwar, Saba Ismail, Bilal Shaker, Sajjad Ahmad   +8 more
doaj   +1 more source

Reverse Vaccinology and Immunoinformatic Assisted Designing of a Multi-Epitopes Based Vaccine Against Nosocomial Burkholderia cepacia

Frontiers in Microbiology, 2022
Burkholderia cepacia is a Gram-negative nosocomial pathogen and is considered as a troublesome bacterium due to its resistance to many common antibiotics.
Noorah Alsowayeh, Aqel Albutti, Samia T. Al-Shouli   +2 more
doaj   +1 more source

Identification of a Potential Vaccine against Treponema pallidum Using Subtractive Proteomics and Reverse-Vaccinology Approaches

Vaccines, 2022
Syphilis, a sexually transmitted infection, is a deadly disease caused by Treponema pallidum. It is a Gram-negative spirochete that can infect nearly every organ of the human body. It can be transmitted both sexually and perinatally.
Siyab Khan, Muhammad Rizwan, Adnan Zeb, Muhammad Alaa Eldeen, Said Hassan, Ashfaq Ur Rehman, Refaat A. Eid, Mohamed Samir A. Zaki, Ghadeer M. Albadrani, Ahmed E. Altyar, Nehal Ahmed Talaat Nouh, Mohamed M. Abdel-Daim, Amin Ullah   +12 more
doaj   +1 more source

INDI – Integrated Nanobody Database for Immunoinformatics [PDF]

Nucleic Acids Research, 2021
AbstractNanobodies, a subclass of antibodies found in camelids, are a versatile molecular binding scaffold composed of a single polypeptide chain. The small size of nanobodies bestows multiple therapeutic advantages (stability, tumor penetration) with the first therapeutic approval in 2018 cementing the clinical viability of this format.
Piotr Deszyński, Jakub Młokosiewicz, Adam Volanakis, Igor Jaszczyszyn, Natalie Castellana, Stefano Bonissone, Rajkumar Ganesan, Konrad Krawczyk   +7 more
openaire   +3 more sources

MatchTope: A tool to predict the cross reactivity of peptides complexed with Major Histocompatibility Complex I

Frontiers in Immunology, 2022
The therapeutic targeting of the immune system, for example in vaccinology and cancer treatment, is a challenging task and the subject of active research.
Marcus Fabiano de Almeida Mendes, Marcelo de Souza Bragatte, Priscila Vianna, Martiela Vaz de Freitas, Ina Pöhner, Stefan Richter, Rebecca C. Wade, Rebecca C. Wade, Francisco Mauro Salzano, Gustavo Fioravanti Vieira, Gustavo Fioravanti Vieira   +10 more
doaj   +1 more source

Designing a Next-Generation Multiepitope-Based Vaccine against Staphylococcus aureus Using Reverse Vaccinology Approaches

Pathogens, 2023
Staphylococcus aureus is a human bacterial pathogen that can cause a wide range of symptoms. As virulent and multi-drug-resistant strains of S. aureus have evolved, invasive S.
Soumya Ranjan Mahapatra, Jyotirmayee Dey, T. Kiran Raj, Namrata Misra, Mrutyunjay Suar   +4 more
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Identification of B-Cell Linear Epitopes in the Nucleocapsid (N) Protein B-Cell Linear Epitopes Conserved among the Main SARS-CoV-2 Variants

Viruses, 2023
The Nucleocapsid (N) protein is highlighted as the main target for COVID-19 diagnosis by antigen detection due to its abundance in circulation early during infection.
Rodrigo N. Rodrigues-da-Silva, Fernando P. Conte, Gustavo da Silva, Ana L. Carneiro-Alencar, Paula R. Gomes, Sergio N. Kuriyama, Antonio A. F. Neto, Josué C. Lima-Junior   +7 more
doaj   +1 more source