Immunoinformatic development of a multiepitope messenger RNA vaccine targeting lipoate protein ligase and dihydrolipoamide dehydrogenase proteins of Mycoplasma bovis in cattle [PDF]
Veterinary WorldBackground and Aim: Mycoplasma bovis is a significant pathogen in cattle, causing respiratory, reproductive, and mammary diseases, leading to substantial economic losses.
Dhafer Rasheed Al-Fetly +2 more
doaj +2 more sources
Targeting Polyprotein to Design Potential Multiepitope Vaccine against Omsk Hemorrhagic Fever Virus (OHFV) by Evaluating Allergenicity, Antigenicity, and Toxicity Using Immunoinformatic Approaches [PDF]
BiologyOmsk Hemorrhagic Fever Virus (OHFV) is an RNA virus with a single-stranded, positive-sense genome. It is classified under the Flaviviridae family. The genome of this virus is 98% similar to the Alkhurma hemorrhagic fever virus (AHFV), which belongs to ...
Abdullah M. Alnuqaydan +1 more
doaj +2 more sources
Immunogenicity of Trypanosoma cruzi Multi-Epitope Recombinant Protein as an Antigen Candidate for Chagas Disease Vaccine in Humans [PDF]
PathogensChagas disease, caused by the protozoan Trypanosoma cruzi (T. cruzi), is the most significant neglected tropical disease affecting individuals in the Americas.
Christian F. Teh-Poot +7 more
doaj +2 more sources
Veterinary Medicine and ScienceThe illness caused by Lactococcus garvieae and Streptococcus iniae is well acknowledged as a disease that results in significant economic losses since it affects a diverse array of fish species.
Ramesh Ranjbar +2 more
doaj +2 more sources
Veterinary Medicine and ScienceThe viral haemorrhagic septicaemia virus (VHSV) is considered a very significant disease affecting fish. The objective of this project is to develop a multi‐epitope vaccine targeting viral hemorrhagic fever using the reverse vaccinology approach. Epitope
Ramin Shukripour +3 more
doaj +2 more sources
Immunoinformatic design of a multivalent vaccine against Brucella abortus and its evaluation in a murine model using a DNA prime-protein boost strategy [PDF]
Frontiers in ImmunologyIntroductionThe development of effective vaccines against Brucella abortus is critical due to its significant impact on human and animal health. The objective of this study was to design and evaluate in silico and in vivo a multivalent vaccine based on ...
Raúl E. Molina +6 more
doaj +2 more sources
Advanced vaccinomic, immunoinformatic, and molecular modeling strategies for designing Multi- epitope vaccines against the Enterobacter cloacae complex [PDF]
Frontiers in ImmunologyThe increasing and ongoing issue of antibiotic resistance in bacteria is of huge concern globally, mainly to healthcare facilities. It is now crucial to develop a vaccine for therapeutic and preventive purposes against the bacterial species causing ...
Hassan H. Alhassan
doaj +2 more sources
Development of multi-epitope Cathepsin L driven short peptide vaccine against Fasciola gigantica [PDF]
Frontiers in Veterinary ScienceFasciolosis is an important zoonotic disease caused by Fasciola species (Fasciola spp.). Fasciola spp. infection has the potential to affect the livestock economy.
Supanan Chansap +4 more
doaj +2 more sources
In Silico Design of a Multiepitope Vaccine Against Intestinal Pathogenic Escherichia coli Based on the 2011 German O104:H4 Outbreak Strain Using Reverse Vaccinology and an Immunoinformatic Approach [PDF]
DiseasesEman G. Youssef +2 more
openalex +2 more sources
Immunoinformatics: Predicting Peptide–MHC Binding [PDF]
Annual Review of Biomedical Data Science, 2020 Immunoinformatics is a discipline that applies methods of computer science to study and model the immune system. A fundamental question addressed by immunoinformatics is how to understand the rules of antigen presentation by MHC molecules to T cells, a process that is central to adaptive immune responses to infections and cancer.
Nielsen, Morten +3 more
openaire +4 more sources