Results 21 to 30 of about 3,331 (204)

Design of a Multi-Epitopes Based Chimeric Vaccine against Enterobacter cloacae Using Pan-Genome and Reverse Vaccinology Approaches

Vaccines, 2022
Enterobacter cloacae (EC) is a significant emerging pathogen that is occasionally associated with lung infection, surgical site infection, urinary infection, sepsis, and outbreaks in neonatal intensive care units.
Wafa Abdullah I. Al-Megrin, Alaa Karkashan, Abdullah M. Alnuqaydan, Faris F. Aba Alkhayl, Faris Alrumaihi, Ahmad Almatroudi, Khaled S. Allemailem   +6 more
doaj   +1 more source

Identification and In Silico Characterization of a Conserved Peptide on Influenza Hemagglutinin Protein: A New Potential Antigen for Universal Influenza Vaccine Development

Nanomaterials, 2023
Antigenic changes in surface proteins of the influenza virus may cause the emergence of new variants that necessitate the reformulation of influenza vaccines every year.
Atin Khalaj-Hedayati, Seyedehmaryam Moosavi, Otilia Manta, Mohamed H. Helal, Mohamed M. Ibrahim, Zeinhom M. El-Bahy, Ganden Supriyanto   +6 more
doaj   +1 more source

Immunoinformatics: an integrated scenario [PDF]

Immunology, 2010
SummaryGenome sequencing of humans and other organisms has led to the accumulation of huge amounts of data, which include immunologically relevant data. A large volume of clinical data has been deposited in several immunological databases and as a result immunoinformatics has emerged as an important field which acts as an intersection between ...
Namrata, Tomar, Rajat K, De
openaire   +2 more sources

A comprehensive approach to developing a multi-epitope vaccine against Mycobacterium tuberculosis: from in silico design to in vitro immunization evaluation

Frontiers in Immunology, 2023
IntroductionThe Bacillus Calmette-Guérin (BCG) vaccine, currently used against tuberculosis (TB), exhibits inconsistent efficacy, highlighting the need for more potent TB vaccines.Materials and methodsIn this study, we employed reverse vaccinology ...
Fan Jiang, Fan Jiang, Fan Jiang, Fan Jiang, Yong Han, Yinping Liu, Yong Xue, Peng Cheng, Li Xiao, Wenping Gong   +9 more
doaj   +1 more source

Sph2_(176–191) and Sph2_(446–459): Identification of B-Cell Linear Epitopes in Sphingomyelinase 2 (Sph2), Naturally Recognized by Patients Infected by Pathogenic Leptospires

Vaccines, 2023
Sphingomyelin is a major constituent of eukaryotic cell membranes, and if degraded by bacteria sphingomyelinases may contribute to the pathogenesis of infection.
Laura Sant’Anna Ataides, Fernanda de Moraes Maia, Fernando Paiva Conte, Lourdes Isaac, Angela Silva Barbosa, Josué da Costa Lima-Junior, Kátia Eliane Santos Avelar, Rodrigo Nunes Rodrigues-da-Silva   +7 more
doaj   +1 more source

Bioinformatics, Computational Informatics, and Modeling Approaches to the Design of mRNA COVID-19 Vaccine Candidates

Computation, 2022
This article is devoted to applying bioinformatics and immunoinformatics approaches for the development of a multi-epitope mRNA vaccine against the spike glycoproteins of circulating SARS-CoV-2 variants in selected African countries.
Olugbenga Oluseun Oluwagbemi, Elijah K. Oladipo, Olatunji M. Kolawole, Julius K. Oloke, Temitope I. Adelusi, Boluwatife A. Irewolede, Emmanuel O. Dairo, Ayodele E. Ayeni, Kehinde T. Kolapo, Olawumi E. Akindiya, Jerry A. Oluwasegun, Bamigboye F. Oluwadara, Segun Fatumo   +12 more
doaj   +1 more source

“Immunoinformatic Identification of T-Cell and B-Cell Epitopes From Giardia lamblia Immunogenic Proteins as Candidates to Develop Peptide-Based Vaccines Against Giardiasis”

Frontiers in Cellular and Infection Microbiology, 2021
Giardiasis is one of the most common gastrointestinal infections worldwide, mainly in developing countries. The etiological agent is the Giardia lamblia parasite.
Thania Garzon, David Ortega-Tirado, Gloria Lopez-Romero, Efrain Alday, Ramón Enrique Robles-Zepeda, Adriana Garibay-Escobar, Carlos Velazquez   +6 more
doaj   +1 more source

Unraveling tumor specific neoantigen immunogenicity prediction: a comprehensive analysis

Frontiers in Immunology, 2023
IntroductionIdentification of tumor specific neoantigen (TSN) immunogenicity is crucial to develop peptide/mRNA based anti-tumoral vaccines and/or adoptive T-cell immunotherapies; thus, accurate in-silico classification/prioritization proves critical for
Guadalupe Nibeyro, Veronica Baronetto, Juan I. Folco, Pablo Pastore, Maria Romina Girotti, Laura Prato, Gabriel Morón, Gabriel Morón, Hugo D. Luján, Hugo D. Luján, Elmer A. Fernández, Elmer A. Fernández, Elmer A. Fernández   +12 more
doaj   +1 more source

A novel therapeutic multiepitope vaccine based on oncoprotein E6 and E7 of HPV 16 and 18: An in silico approach [PDF]

BioImpacts
Introduction: The current vaccine strategies to prevent cervical cancer are effective only for individuals unexposed to HPV, lacking therapeutic effects against pre-existing infections.
Sari Eka Pratiwi, Ysrafil Ysrafil, Mardhia Mardhia, Mahyarudin Mahyarudin, Muhammad Inam Ilmiawan, Heru Fajar Trianto, Delima Fajar Liana, Yuri Amia   +7 more
doaj   +1 more source

Regulation of Host Immune Response against Enterobacter cloacae Proteins via Computational mRNA Vaccine Design through Transcriptional Modification

Microorganisms, 2022
Enterobacter cloacae is mainly responsible for sepsis, urethritis, and respiratory tract infections. These bacteria may affect the transcription of the host and particularly their immune system by producing changes in their epigenetics.
Muhammad Naveed, Khizra Jabeen, Rubina Naz, Muhammad Saad Mughal, Ali A. Rabaan, Muhammed A. Bakhrebah, Fahad M. Alhoshani, Mohammed Aljeldah, Basim R. Al Shammari, Mohammed Alissa, Amal A. Sabour, Rana A. Alaeq, Maha A. Alshiekheid, Mohammed Garout, Mohammed S. Almogbel, Muhammad A. Halwani, Safaa A. Turkistani, Naveed Ahmed   +17 more
doaj   +1 more source