Results 41 to 50 of about 3,331 (204)

Synthesis of Chirally Chimeric Protein Nanoparticle Vaccines via Mirror‐Image Spy Chemistry

Angewandte Chemie, Volume 137, Issue 34, August 18, 2025.
This study illustrates a versatile strategy for creating chirally chimeric protein constructs by merging natural‐chirality (L‐) and mirror‐image (D‐) protein motifs through a combination of L‐sortase‐mediated transpeptidation and D‐SpyStapler‐mediated ligation.
Songzi Kou, Chenbo Sun, Weitao Chen, Hanyu Gao, Fei Sun   +4 more
wiley   +2 more sources

Designing a multi-epitope vaccine against SARS-CoV-2: an immunoinformatic approach

Инфекция и иммунитет
Background.An outbreak of SARS-CoV-2 in 2019 has brought a great challenge to public health and rapid identification of immune epitopes for designing an effective vaccine for different variants of SARS-CoV-2 is necessary at the time of the pandemic ...
V. Alamdari-Palang, Z. Dehghan, M. Kian, S. Zonar, J. Fallahi, M. Sisakht, S. Khajeh, V. Razban   +7 more
doaj   +1 more source

Multi-Epitope-Based Vaccine Candidate for Monkeypox: An In Silico Approach

Vaccines, 2022
Currently, there are limited treatment options available for the monkeypox disease. We used a computational strategy to design a specific antigenic vaccine against pathogens.
Sayed Aliul Hasan Abdi, Amena Ali, Shabihul Fatma Sayed, Abutahir, Abuzer Ali, Prawez Alam   +5 more
doaj   +1 more source

Immunoinformatics‐Based Multi‐Epitope Vaccine Targeting Helicobacter Pylori

Cancer Reports, Volume 9, Issue 1, January 2026.
ABSTRACT Background The rising global incidence of Helicobacter pylori‐related diseases, particularly gastric cancer, underscores the urgent need for effective preventive vaccines, motivating the exploration of innovative immunoinformatic strategies to address this public health challenge.
Aytak Vahdat Khajeh Pasha, Mohammad Esfandiyari, Alireza Parnian, Mohammad Mahboubi‐Rabbani, Maryam Bayanati   +4 more
wiley   +1 more source

Designing and Evaluation of a Multiepitope Vaccine against Avian Newcastle Disease Virus, Influenza Virus and Infectious Bronchitis Virus [PDF]

Pharmaceutical Sciences
Background: Poultry industries play an important role in the human food supply. Newcastle disease virus (NDV), Infectious bronchitis virus (IBV), and Avian influenza virus (AIV) can cause epizootic outbreaks in poultry industries and lead to extensive ...
Morteza Ghandadi
doaj   +1 more source

Is Toxoplasma gondii‐secreted Protein With an Altered Thrombospondin Repeat (TgSPATR) a Potential Candidate for Immunisation? An Immunoinformatics‐Based Analysis

Veterinary Medicine and Science, Volume 12, Issue 1, January 2026.
Toxoplasma gondii‐secreted protein with an altered thrombospondin repeat was computationally characterised as an immunogenic, non‐allergenic protein carrying multiple B‐ and T‐cell epitopes. Structural validation and immune simulation suggest its strong potential as a vaccine candidate against toxoplasmosis.
Masoud Foroutan, Elaheh Karimzadeh‐Soureshjani, Fatemeh Ghaffarifar   +2 more
wiley   +1 more source

Design of B‐Cell Multi‐Epitope Subunit Vaccines Against Glaesserella parasuis by Reverse Vaccinology: An In Silico and In Vivo Study

Transboundary and Emerging Diseases, Volume 2026, Issue 1, 2026.
Glässer’s disease caused by Glaesserella parasuis (GPS) is a severe disease that results in substantial economic losses to the swine industry worldwide. Here we describe a multiepitope vaccine cocktail (MEVC) that was designed using reverse vaccinology and immunoinformatics. The MEVC was comprised of three multiepitope subunits (MESs, designated as TB,
Yan Gong, Na Li, Ziheng Li, He Wang, Di Zhang, Hong Chu, Zhichao Lu, Aiqing Jia, Fengyang Li, Liancheng Lei, Zhong Peng   +10 more
wiley   +1 more source

A Serum‐Stable Antimicrobial Peptide‐Based Delivery Platform for Selective Treatment of Nontargetable and Chemoresistant Tumors

Advanced Science, Volume 12, Issue 45, December 4, 2025.
A modular antimicrobial‐peptide‐based therapeutic system integrating membrane‐targeted selectivity, a conformation‐driven polyethylene glycolylated blocker, and serum‐stabilizing N‐cap is developed. The optimized conjugate 270 shows potent, rapid killing of the desired tumor cells, high serum stability, low off‐target toxicity, and broad applicability,
Tianxing Liu, Lingyu Ke, Ruize Sun, Xiaoling Chen, Mei Zhou, Olaf R. P. Bininda‐Emond, Chengbang Ma, Yangyang Jiang, Tao Wang, Chris Shaw, Lei Wang, Tianbao Chen, Alideertu Dong   +12 more
wiley   +1 more source

Cocktail Antigen Presenting Peptide Vaccine Development for Nipah Virus: An Immunoinformatic Approach to Indian and Malaysian Strain

Journal of Pure and Applied Microbiology
Nipah virus (NiV) is an emerging zoonotic pathogen of global concern, causing serious life-threatening illness in humans. The first outbreak was reported from Malaysia in 1998. The virus is classified under the family Paramyxoviridae. Geographically, the
Naseera Kannanthodi Pariyapurath, Sarika Baburajan Pillai, Kavitha Dhandapani, Rahulgandhi Pachamuthu, Shivanandhappa Kukkaler Channappa, Ananda Arona Premkumar, Maghimaa Mathanmohun, Pachamuthu Balakrishnan, Sathish Sankar, Selvaraj Jagannathan   +9 more
doaj   +1 more source

FRED 2: an immunoinformatics framework for Python [PDF]

Bioinformatics, 2016
Abstract Summary: Immunoinformatics approaches are widely used in a variety of applications from basic immunological to applied biomedical research. Complex data integration is inevitable in immunological research and usually requires comprehensive pipelines including multiple tools and data sources. Non-standard input and output formats
Schubert, Benjamin, Walzer, Mathias, Brachvogel, Hans-Philipp, Szolek, András, Mohr, Christopher, Kohlbacher, Oliver   +5 more
openaire   +3 more sources