Results 51 to 60 of about 3,331 (204)

mRNA Cancer Vaccines: From Pandemic Paradigm to Personalized Oncology Therapeutics

Cancer Innovation, Volume 4, Issue 6, December 2025.
This review highlights the transformative potential of mRNA cancer vaccines, leveraging technological advancements in nucleotide modification, lipid nanoparticle delivery, and AI‐driven neoantigen selection to enhance vaccine stability, immunogenicity, and personalization.
Bo Yang, Juan Liu, Yang Li, Xiaoxuan Liu
wiley   +1 more source

Genomic and Immunoinformatics Insights Into a Bovine‐Derived Brucella abortus S19 Field Strain: Adaptations Impacting Vaccine Efficacy

Veterinary Medicine and Science, Volume 11, Issue 6, November 2025.
This study presents a comprehensive genomic and immunoinformatics analysis of a bovine‐derived Brucella abortus S19 field strain, revealing significant antigenic variations and virulence adaptations impacting vaccine efficacy. These findings provide insights for designing improved vaccines tailored to regional epidemiological needs.
Ali Arslan, Emre Aktas, Osman Ugur Sezerman, Tulin Ozbek   +3 more
wiley   +1 more source

Immunoinformatics Study: Multi-Epitope Based Vaccine Design from SARS-CoV-2 Spike Glycoprotein

Vaccines, 2023
The coronavirus disease 2019 outbreak has become a huge challenge in the human sector for the past two years. The coronavirus is capable of mutating at a higher rate than other viruses.
Ramadhita Umitaibatin, Azza Hanif Harisna, Muhammad Miftah Jauhar, Putri Hawa Syaifie, Adzani Gaisani Arda, Dwi Wahyu Nugroho, Donny Ramadhan, Etik Mardliyati, Wervyan Shalannanda, Isa Anshori   +9 more
doaj   +1 more source

ImmunoNodes – graphical development of complex immunoinformatics workflows [PDF]

BMC Bioinformatics, 2017
Immunoinformatics has become a crucial part in biomedical research. Yet many immunoinformatics tools have command line interfaces only and can be difficult to install. Web-based immunoinformatics tools, on the other hand, are difficult to integrate with other tools, which is typically required for the complex analysis and prediction pipelines required ...
Benjamin Schubert, Luis de la Garza, Christopher Mohr, Mathias Walzer, Oliver Kohlbacher   +4 more
openaire   +5 more sources

Immunoinformatics‐Based Multi‐Epitope Vaccine Design Against P. falciparum‐Causing Malaria: A Computational Approach

Health Science Reports, Volume 8, Issue 10, October 2025.
ABSTRACT Background and Aim Malaria is an infectious disease that affects people in Africa, and other parts of the world by the millions. Despite the effectiveness of artemisinin‐based combination therapies against the disease, current findings on possible Plasmodium resistance to artemisinin warrants an exploration of new treatment options. This study
Amma Aboagyewa Larbi, Caleb Mensah, Rebecca Korankye, Andrew Appiah Darkwah, Esther Boakye Agyemang, Isaac Yao Ayikpah, Alexander Kwarteng   +6 more
wiley   +1 more source

A Mutation‐Based Reverse Vaccinology Approach Considering Variability in Epitopes to Combat Multi‐Strains: A Study Using Glycoprotein of LASV

Journal of Cellular and Molecular Medicine, Volume 29, Issue 20, October 2025.
ABSTRACT Lassa virus (LASV) remains a persistent threat to public health, and to combat this, various therapeutics have been developed, but their effectiveness is limited due to the virus's strain variability. Therefore, mutation‐based reverse vaccinology approaches were implemented to formulate an epitope‐based vaccine against the LASV, considering ...
Saurav Kumar Mishra, Rajesh B. Patil, Amdola Tshering Sherpa, Mohammad Borhan Uddin, Md. Harun‐Or‐Rashid, Muniruddin Ahmed, Turki M. Dawoud, John J. Georrge   +7 more
wiley   +1 more source

Design of a Multi-Epitope Vaccine against Histoplasma capsulatum through Immunoinformatics Approaches

Journal of Fungi
Histoplasmosis is a widespread systemic disease caused by Histoplasma capsulatum, prevalent in the Americas. Despite its significant morbidity and mortality rates, no vaccines are currently available.
Pedro Henrique Marques, Sandeep Tiwari, Andrei Giacchetto Felice, Arun Kumar Jaiswal, Flávia Figueira Aburjaile, Vasco Azevedo, Mario León Silva-Vergara, Kennio Ferreira-Paim, Siomar de Castro Soares, Fernanda Machado Fonseca   +9 more
doaj   +1 more source

Whole-genome immunoinformatic analysis of F. tularensis: predicted CTL epitopes clustered in hotspots are prone to elicit a T-cell response. [PDF]

PLoS ONE, 2011
The cellular arm of the immune response plays a central role in the defense against intracellular pathogens, such as F. tularensis. To date, whole genome immunoinformatic analyses were limited either to relatively small genomes (e.g.
Anat Zvi, Shahar Rotem, Erez Bar-Haim, Ofer Cohen, Avigdor Shafferman   +4 more
doaj   +1 more source

Bioinformatics and immunoinformatics to support COVID‐19 vaccine development [PDF]

, 2021
Stephanie Ishack, Shari R. Lipner
openalex   +1 more source

T‐cell receptor insights: Determinants of Major Histocompatibility Complex class I versus class II recognition

Protein Science, Volume 34, Issue 9, September 2025.
Abstract In this study, we analyzed large‐scale T‐cell receptor (TCR) sequence data to determine whether TCRs preferentially bind to major histocompatibility complex (MHC) class I (CD8+) or class II (CD4+) epitopes. Using the International ImMunoGeneTics information system numbering scheme, we identified specific positions with distinct amino acid ...
Marcus De Almeida Mendes, Leila Chihab, Jonas Birkelund Nilsson, Lonneke Scheffer, Morten Nielsen, Bjoern Peters   +5 more
wiley   +1 more source