Results 21 to 30 of about 9,537,711 (374)

Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases.

Journal of Immunology, 1995
Approximately 10% of peripheral CD4+ cells and less than 1% of CD8+ cells in normal unimmunized adult mice express the IL-2 receptor alpha-chain (CD25) molecules.
S. Sakaguchi, N. Sakaguchi, M. Asano, M. Itoh, M. Toda   +4 more
semanticscholar   +1 more source

The immunology of coeliac disease

Springer Seminars in Immunopathology, 1990
Whether or not the immune system initiates CD, it can be seen to play a role in the natural history of the disease. Genetic susceptibility to CD has been shown to be linked to the HLA, DQw2 and it appears that other genes within the MHC further contribute to disease susceptibility. The search for other immune response genes that may be linked to CD has
Mantzaris, G, Rosenberg, WM, Jewell, D
openaire   +4 more sources

Immunologic Effects of Vitamin D on Human Health and Disease

Nutrients, 2020
Vitamin D is responsible for regulation of calcium and phosphate metabolism and maintaining a healthy mineralized skeleton. It is also known as an immunomodulatory hormone.
N. Charoenngam, M. Holick
semanticscholar   +1 more source

The HLA class II allele DRB1*1501 is over-represented in patients with idiopathic pulmonary fibrosis [PDF]

, 2011
Background: Idiopathic pulmonary fibrosis (IPF) is a progressive and medically refractory lung disease with a grim prognosis. Although the etiology of IPF remains perplexing, abnormal adaptive immune responses are evident in many afflicted patients.
A Shimizudani, A Warrens, A-L Katzenstein, Adriana Zeevi, Ahmad Samer Alawad, AN Vallejo, Bernadette R. Gochuico, C Evans, C Taillé, CA Feghali-Bostwick, CA Stewart, Carl R. Fuhrman, Carol A. Feghali-Bostwick, CEM Voorter, CJ Lettieri, CL Vanderlugt, CM Magro, CV Strimlan, CWG Turton, D Falkner, DM Libby, E Varpela, EF Perez, F Ogushi, F Takeuchi, FC Hall, Frank C. Sciurba, Glenn D. Rosen, H Schmidt, HR Collard, I Kotslanidis, Iclal Ocak, Imre Noth, IO Rosas, Ivan O. Rosas, J Homolka, J Marchal-Somme, J Marchal-Somme, JA Traherne, JC Grutters, JD Fulmer, Jianmin Xue, Joseph M. Pilewski, K Kurosu, Karen T. Cuenco, Kevin F. Gibson, M Kreider, M Selman, Mary A. Smith, MB Oldstone, Melanie Koenigshoff, MG Rudolph, N Dobashi, Naftali Kaminski, P Ren, Penelope A. Morel, PI de Bakker, R Falfan-Valenci, SA Papiris, Sanja Dacic, SM Studer, SR Gilani, Steven D. Nathan, Steven R. Duncan, Susan S. Jacobs, T Takahashi, Vincent G. Valentine, W Klitz, WE Lawson, Yingze Zhang   +69 more
core   +10 more sources

RBPJ Controls Development of Pathogenic Th17 Cells by Regulating IL-23 Receptor Expression

Cell Reports, 2016
Interleukin-17 (IL-17)-producing helper T cells (Th17 cells) play an important role in autoimmune diseases. However, not all Th17 cells induce tissue inflammation or autoimmunity. Th17 cells require IL-23 receptor (IL-23R) signaling to become pathogenic.
Gerd Meyer zu Horste, Chuan Wu, Chao Wang, Le Cong, Mathias Pawlak, Youjin Lee, Wassim Elyaman, Sheng Xiao, Aviv Regev, Vijay K. Kuchroo   +9 more
doaj   +1 more source

The immunology of Parkinson’s disease

Seminars in Immunopathology, 2022
AbstractParkinson’s disease (PD) is the second most common neurodegenerative disorder which affects 6.1 million people worldwide. The neuropathological hallmarks include the loss of dopaminergic neurons in the substantia nigra, the presence of Lewy bodies and Lewy neurites caused by α-synuclein aggregation, and neuroinflammation in the brain.
Biqing Zhu, Dominic Yin, Hongyu Zhao, Le Zhang   +3 more
openaire   +2 more sources

Uveitis and hypereosinophilia associated with dupilumab in an atopic dermatitis patient

Journal of Dermatological Treatment, 2023
Uveitis is a rare adverse event of dupilumab, that typically affects both eyes and often leads to discontinuation of therapy. In this article, we report a case of a 28-year-old female with atopic dermatitis who developed new-onset iridocyclitis, a form ...
Shiyu Zhang, Lu Lu, Jindi Feng, Zhonghui Hu, Hongbin Song, Lu Yang, Yuehua Liu, Di Chen, Tao Wang   +8 more
doaj   +1 more source

Diagnostic Value Parameters Of Acute Phase Reactances Of Infectious-inflammatory Process In Diagnostics Of Early Neonatal Sepsis [PDF]

, 2018
An advanced progress of clinical neonatology in recent years has enabled to achieve considerable success in newborn management with due respect to both medical treatment and general care, especially in the group of neonates with low body weight at birth.
Bezrukov, L. (Leonid), Koloskova, O. (Olena), Vlasova, O. (Olena)   +2 more
core   +2 more sources

Peripheral B-Cell Immunophenotyping Identifies Heterogeneity in IgG4-Related Disease

Frontiers in Immunology, 2021
ObjectivesTo elucidate heterogeneity of IgG4-related disease (IgG4-RD) based on B cell immunophenotyping.MethodsImmunophenotyping of 4 B-cell subsets in peripheral blood from patients with active IgG4-RD (aIgG4-RD, n=105) was performed using flow ...
Jieqiong Li, Zheng Liu, Panpan Zhang, Wei Lin, Hui Lu, Yu Peng, Linyi Peng, Jiaxin Zhou, Mu Wang, Hua Chen, Lidan Zhao, Li Wang, Chenman Qin, Chaojun Hu, Xiaofeng Zeng, Yan Zhao, Yunyun Fei, Wen Zhang   +17 more
doaj   +1 more source

Parasitic helminth infections and the control of human allergic and autoimmune disorders [PDF]

, 2016
The profile of global health today presents a striking reciprocal distribution between parasitic diseases in many of the world’s lower-income countries, and ever-increasing levels of inflammatory disorders such as allergy, autoimmunity and inflammatory ...
Araujo, Asher, Babu, Bager, Benzel, Bourke, Broadhurst, Colley, Cooper, Cooper, Correale, Correale, Correale, Croese, Daveson, Economou, Evans, Feary, Feary, Feary, Finlay, Fleming, Fleming, Fleming, Flohr, Gale, Garg, Greenwood, Harnett, Harnett, Helmby, Hewitson, Heylen, Hotez, Hussaarts, Jeannin, Johnston, Johnston, Jouvin, King, Kurniawan, Labeaud, Leonardi, Mahanty, Maizels, Maizels, Maizels, Mbow, McKay, McKay, McSorley, McSorley, McSorley, Metenou, Mishra, Mutapi, Navarro, Platts-Mills, R.M. Maizels, Sakaguchi, Salgame, Sartono, Schnoeller, Shepherd, Smits, Summers, Summers, Summers, Thorburn, van den Biggelaar, van den Biggelaar, Velasquez-Manoff, Voldsgaard, Wammes, Wammes, Watanabe, Weinstock   +76 more
core   +1 more source