Immunopathogenesis of rheumatoid arthritis [PDF]
Rheumatoid arthritis (RA) is the most common inflammatory arthropathy. The majority of evidence, derived from genetics, tissue analyses, models, and clinical studies, points to an immune-mediated etiology associated with stromal tissue dysregulation that
Ahmed +115 more
core +1 more source
Peripheral B-Cell Immunophenotyping Identifies Heterogeneity in IgG4-Related Disease
ObjectivesTo elucidate heterogeneity of IgG4-related disease (IgG4-RD) based on B cell immunophenotyping.MethodsImmunophenotyping of 4 B-cell subsets in peripheral blood from patients with active IgG4-RD (aIgG4-RD, n=105) was performed using flow ...
Jieqiong Li +17 more
doaj +1 more source
Diagnostic Value Parameters Of Acute Phase Reactances Of Infectious-inflammatory Process In Diagnostics Of Early Neonatal Sepsis [PDF]
An advanced progress of clinical neonatology in recent years has enabled to achieve considerable success in newborn management with due respect to both medical treatment and general care, especially in the group of neonates with low body weight at birth.
Bezrukov, L. (Leonid) +2 more
core +2 more sources
Kinetoplastids:related protozoan pathogens, different diseases [PDF]
Kinetoplastids are a group of flagellated protozoans that include the species Trypanosoma and Leishmania, which are human pathogens with devastating health and economic effects. The sequencing of the genomes of some of these species has highlighted their
Agranoff +127 more
core +4 more sources
Alterations of the human gut microbiome in multiple sclerosis
The gut microbiome has been implicated in several autoimmune disorders. Here, the authors study the gut microbiome of patients with multiple sclerosis, and find correlations between altered abundance of certain gut microorganisms and changes in ...
Sushrut Jangi +24 more
doaj +1 more source
Predictors of Failure from Primary Therapy for Giardiasis in San Diego: A Single Institution Retrospective Review. [PDF]
This study aimed to determine the presence of giardiasis among HIV patients in San Diego, the rate of failure of metronidazole treatment, and factors associated with treatment failure.
Debnath, Anjan +2 more
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Consensus of Chinese Experts on the Diagnosis and Treatment of Type Ⅰ Interferonopathy
Type Ⅰ interferonopathy is an autoinflammatory disease that affects multiple systems, with a high disability and mortality rate. It profoundly impacts the quality of life of patients and poses a considerable burden on their families and society.
Chinese Alliance of Pediatric Rheumatic & Immunologic Diseases +1 more
doaj +1 more source
On the crossroad between tolerance and posttransplant lymphoma. [PDF]
The role of the Epstein-Barr virus in the development of post-transplant lymphomas is well established. However, not all lymphomas that arise in these patients contain Epstein-Barr virus, suggesting that other cofactors are involved in tumor pathogenesis.
Nalesnik, Michael A, Starzl, Thomas E
core +1 more source
CD4+ T cells secreting interleukin-17 (TH17) have diverse functions in modulating autoimmune diseases. Here the authors show via transcriptome analyses that a subset of human TH 17 co-expressing interferon-γ (TH1/17) has a molecular signature similar to “
Dan Hu +19 more
doaj +1 more source
Single-Cell Sequencing of Immune Cell Heterogeneity in IgG4-Related Disease
BackgroundThe IgG4-related disease (IgG4-RD) is an immune-mediated disorder with fibrotic manifestations. However, the transcriptional profiles of immune cell subsets at single-cell level are unknown. Herein, single-cell sequencing was used to assess the
Xunyao Wu +12 more
doaj +1 more source

