Results 31 to 40 of about 9,586,847 (376)

Peripheral B-Cell Immunophenotyping Identifies Heterogeneity in IgG4-Related Disease

Frontiers in Immunology, 2021
ObjectivesTo elucidate heterogeneity of IgG4-related disease (IgG4-RD) based on B cell immunophenotyping.MethodsImmunophenotyping of 4 B-cell subsets in peripheral blood from patients with active IgG4-RD (aIgG4-RD, n=105) was performed using flow ...
Jieqiong Li, Zheng Liu, Panpan Zhang, Wei Lin, Hui Lu, Yu Peng, Linyi Peng, Jiaxin Zhou, Mu Wang, Hua Chen, Lidan Zhao, Li Wang, Chenman Qin, Chaojun Hu, Xiaofeng Zeng, Yan Zhao, Yunyun Fei, Wen Zhang   +17 more
doaj   +1 more source

Alterations of the human gut microbiome in multiple sclerosis

Nature Communications, 2016
The gut microbiome has been implicated in several autoimmune disorders. Here, the authors study the gut microbiome of patients with multiple sclerosis, and find correlations between altered abundance of certain gut microorganisms and changes in ...
Sushrut Jangi, Roopali Gandhi, Laura M. Cox, Ning Li, Felipe von Glehn, Raymond Yan, Bonny Patel, Maria Antonietta Mazzola, Shirong Liu, Bonnie L. Glanz, Sandra Cook, Stephanie Tankou, Fiona Stuart, Kirsy Melo, Parham Nejad, Kathleen Smith, Begüm D. Topçuolu, James Holden, Pia Kivisäkk, Tanuja Chitnis, Philip L. De Jager, Francisco J. Quintana, Georg K. Gerber, Lynn Bry, Howard L. Weiner   +24 more
doaj   +1 more source

Preserved cellular immunity in smoldering acute leukemia [PDF]

, 1976
"Smoldering acute leukemia", a variant of acute myelogenous leukemia, has been recognized with frequent incidence in recent years. This is chracterized by benign clinical course, poor physical findings, leukopenia and mild anemia in the ...
Toki, Hironobu
core   +1 more source

Clinical Characteristics and Prognoses of Patients With Systemic Lupus Erythematosus Hospitalized for Pulmonary Infections

Frontiers in Medicine, 2021
Objective: To identify factors associated with mortality in SLE patients who were hospitalized for pulmonary infections (PIs).Methods: This single-center retrospective study analyzed the characteristics and risk factors for mortality in 95 SLE patients ...
Yanli Yang, Yanli Yang, Hui Jiang, Chuhan Wang, Nan Jiang, Chanyuan Wu, Shangzhu Zhang, Wei Jiang, Jinmin Peng, Li Weng, Jiuliang Zhao, Qian Wang, Mengtao Li, Bin Du, Yan Zhao, Xiaofeng Zeng   +15 more
doaj   +1 more source

Consensus of Chinese Experts on the Diagnosis and Treatment of Type Ⅰ Interferonopathy

罕见病研究
Type Ⅰ interferonopathy is an autoinflammatory disease that affects multiple systems, with a high disability and mortality rate. It profoundly impacts the quality of life of patients and poses a considerable burden on their families and society.
Chinese Alliance of Pediatric Rheumatic & Immunologic Diseases, Chinese Pharmacists Association Rare Diseases Medication Working Committee   +1 more
doaj   +1 more source

Transcriptional signature of human pro-inflammatory TH17 cells identifies reduced IL10 gene expression in multiple sclerosis

Nature Communications, 2017
CD4+ T cells secreting interleukin-17 (TH17) have diverse functions in modulating autoimmune diseases. Here the authors show via transcriptome analyses that a subset of human TH 17 co-expressing interferon-γ (TH1/17) has a molecular signature similar to “
Dan Hu, Samuele Notarbartolo, Tom Croonenborghs, Bonny Patel, Ron Cialic, Tun-Hsiang Yang, Dominik Aschenbrenner, Karin M. Andersson, Marco Gattorno, Minh Pham, Pia Kivisakk, Isabelle V. Pierre, Youjin Lee, Karun Kiani, Maria Bokarewa, Emily Tjon, Nathalie Pochet, Federica Sallusto, Vijay K. Kuchroo, Howard L. Weiner   +19 more
doaj   +1 more source

Neutrophil Extracellular Traps Promote Aberrant Macrophages Activation in Behçet’s Disease

Frontiers in Immunology, 2021
Neutrophil extracellular traps (NETs) are upregulated and promote thrombosis in Behçet’s disease (BD). However, whether NETs promote autoinflammation in BD remains unclear.
Lu Li, Lu Li, Xin Yu, Jinjing Liu, Zhimian Wang, Chaoran Li, Jing Shi, Luxi Sun, Yi Liu, Fengchun Zhang, Hua Chen, Wenjie Zheng   +11 more
doaj   +1 more source

On the crossroad between tolerance and posttransplant lymphoma. [PDF]

, 1997
The role of the Epstein-Barr virus in the development of post-transplant lymphomas is well established. However, not all lymphomas that arise in these patients contain Epstein-Barr virus, suggesting that other cofactors are involved in tumor pathogenesis.
Nalesnik, Michael A, Starzl, Thomas E
core   +1 more source

The natural course of hereditary angioedema in a Chinese cohort

Orphanet Journal of Rare Diseases, 2020
Background Hereditary angioedema (HAE) is a rare disease with potential life-threatening risks. To study the natural course of HAE under therapy-free conditions throughout patient life is essential for practitioners and patients to avoid possible risk ...
Yang Cao, Shuang Liu, Yuxiang Zhi
doaj   +1 more source

Mutation update of SERPING1 related to hereditary angioedema in the Chinese population

Hereditas, 2022
Background Hereditary angioedema (HAE) is a rare disease characterized by recurrent attacks of severe swellings of the skin and submucosa. More than 900 variants of the SERPING1 gene associated with HAE have been identified.
Xue Wang, Shubin Lei, Yingyang Xu, Shuang Liu, Yuxiang Zhi   +4 more
doaj   +1 more source