Results 21 to 30 of about 42,777 (163)

Revealing the Complexity in CD8 T Cell Responses to Infection in Inbred C57B/6 versus Outbred Swiss Mice

Frontiers in Immunology, 2017
Recent work has suggested that current mouse models may underrepresent the complexity of human immune responses. While most mouse immunology studies utilize inbred mouse strains, it is unclear if conclusions drawn from inbred mice can be extended to all ...
Matthew D. Martin, Derek B. Danahy, Stacey M. Hartwig, Stacey M. Hartwig, John T. Harty, John T. Harty, John T. Harty, Vladimir P. Badovinac, Vladimir P. Badovinac, Vladimir P. Badovinac   +9 more
doaj   +1 more source

Immunological memory ≠ protective immunity [PDF]

Cellular and Molecular Life Sciences, 2012
So-called 'immunological memory' is, in my view, a typical example where a field of enquiry, i.e. to understand long-term protection to survive reexposure to infection, has been overtaken by 'l'art pour l'art' of 'basic immunology'. The aim of this critical review is to point out some key differences between academic text book-defined immunological ...
openaire   +4 more sources

Application of the nanobiotechnology with the system CRISP-Cas

Universidad y Salud, 2017
Introduction: Nanobiotechnology and synthetic biology are sciences that impact today with the launching of innovative and beneficial applications for the human being. These sciences have been amalgamated to manufacture new components for the construction
Liceth Xiomara Sáenz-Castiblanco, Maritza Angarita-Merchán, Diana Paola Lopez-Velandia   +2 more
doaj   +1 more source

Runx Transcription Factors in T Cells—What Is Beyond Thymic Development?

Frontiers in Immunology, 2021
Runx proteins (also known as Runt-domain transcription factors) have been studied for a long time as key regulators of cellular differentiation. RUNX2 has been described as essential for osteogenesis, whereas RUNX1 and RUNX3 are known to control blood ...
Svetlana Korinfskaya, Sreeja Parameswaran, Matthew T. Weirauch, Matthew T. Weirauch, Matthew T. Weirauch, Artem Barski, Artem Barski, Artem Barski   +7 more
doaj   +1 more source

Inmunodeficiencia común variable: caracterización clínica e inmunológica de pacientes e identificación de subgrupos homogéneos con base en la tipificación de subpoblaciones de linfocitos B

Biomédica: revista del Instituto Nacional de Salud, 2015
Introducción. La inmunodeficiencia común variable es un síndrome heterogéneo caracterizado por infecciones recurrentes, hipogammaglobulinemia y producción deficiente de anticuerpos específicos.
Alejandra Catalina Vélez, Diana María Castaño, Rubén Darío Gómez, Julio César Orrego, Marcela Moncada, José Luis Franco   +5 more
doaj   +1 more source

Immunologic difference between hypersensitivity to mosquito bite and hemophagocytic lymphohistiocytosis associated with Epstein-Barr virus infection. [PDF]

PLoS ONE, 2013
Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening, virus-triggered immune disease. Hypersensitivity to mosquito bite (HMB), a presentation of Chronic Active Epstein-Barr Virus infection (CAEBV), may progress to HLH.
Wen-I Lee, Jainn-Jim Lin, Meng-Ying Hsieh, Syh-Jae Lin, Tang-Her Jaing, Shih-Hsiang Chen, Iou-Jih Hung, Chao-Ping Yang, Chin-Jung Chen, Yhu-Chering Huang, Shin-Pai Li, Jing-Long Huang   +11 more
doaj   +1 more source

Case report: ETS1 gene deletion associated with a low number of recent thymic emigrants in three patients with Jacobsen syndrome

Frontiers in Immunology, 2022
Jacobsen syndrome is a rare genetic disorder associated with a terminal deletion in chromosome 11. The clinical presentation is variable. Although immunodeficiency has been described in patients with Jacobsen syndrome, a clear genotype-phenotype ...
Tina Trachsel, Seraina Prader, Katharina Steindl, Jana Pachlopnik Schmid, Jana Pachlopnik Schmid   +4 more
doaj   +1 more source

The presence of anti-nuclear antibodies alone is associated with changes in B cell activation and T follicular helper cells similar to those in systemic autoimmune rheumatic disease

Arthritis Research & Therapy, 2018
Background Diagnosis of systemic autoimmune rheumatic diseases (SARD) relies on the presence of hallmark anti-nuclear antibodies (ANA), many of which can be detected years before clinical manifestations. However, ANAs are also seen in healthy individuals,
Yuriy Baglaenko, Nan-Hua Chang, Sindhu R. Johnson, Waleed Hafiz, Kieran Manion, Dario Ferri, Babak Noamani, Dennisse Bonilla, Sina Rusta-Sellehy, Larissa Lisnevskaia, Earl Silverman, Arthur Bookman, Carolina Landolt-Marticorena, Joan Wither   +13 more
doaj   +1 more source

Cellular size as a means of tracking mTOR activity and cell fate of CD4+ T cells upon antigen recognition. [PDF]

PLoS ONE, 2015
mTOR is a central integrator of metabolic and immunological stimuli, dictating immune cell activation, proliferation and differentiation. In this study, we demonstrate that within a clonal population of activated T cells, there exist both mTORhi and ...
Kristen N Pollizzi, Adam T Waickman, Chirag H Patel, Im Hong Sun, Jonathan D Powell   +4 more
doaj   +1 more source

A delayed fractionated dose RTS,S AS01 vaccine regimen mediates protection via improved T follicular helper and B cell responses

eLife, 2020
Malaria-071, a controlled human malaria infection trial, demonstrated that administration of three doses of RTS,S/AS01 malaria vaccine given at one-month intervals was inferior to a delayed fractional dose (DFD) schedule (62.5% vs 86.7% protection ...
Suresh Pallikkuth, Sidhartha Chaudhury, Pinyi Lu, Li Pan, Erik Jongert, Ulrike Wille-Reece, Savita Pahwa   +6 more
doaj   +1 more source