Severe intestinal barrier damage in HIV-infected immunological non-responders [PDF]
Heliyon, 2023 The intestinal epithelial barrier plays an important role during human immunodeficiency virus (HIV) disease progression. However, the extent to which the intestinal epithelial barrier is damaged in immunological non-responders (INRs) and immunological ...
Xiao-Yan Guo +18 more
doaj +4 more sources
Dysfunction and Metabolic Reprogramming of Gut Regulatory T Cells in HIV-Infected Immunological Non-Responders [PDF]
CellsDisruption of the gut microenvironment is a hallmark of HIV infection, where regulatory T cells (Tregs) play a critical role in maintaining gut homeostasis.
Minrui Yu +12 more
doaj +4 more sources
Enhanced immune reconstitution with albuvirtide in HIV-infected immunological non-responders [PDF]
Frontiers in Cellular and Infection MicrobiologyBackgroundIncomplete immune recovery in people living with HIV/AIDS (PLWHA) remains an important clinical challenge with the lack of an effective strategy currently available to restore their T-cell immune response.
Lina Fan +16 more
doaj +4 more sources
Unveiling neuroimmunology profile of immunological non-responders in HIV: a multimodal MRI approach [PDF]
Frontiers in ImmunologyBackgroundPeople living with HIV (PLWH), especially immunological non-responders (INRs), may experience adverse neurologic events. However, the extent of neurological impairment in INRs remains uncertain. This study evaluates brain structure and function,
Yang Zhang +19 more
doaj +4 more sources
Elevated Levels of Pro-Inflammatory Interleukin-6 in HIV Immunological Non-Responders Among the Indonesian Population [PDF]
DiagnosticsApproximately 10–35% of people living with HIV (PLHIV) on antiretroviral therapy (ART) fail to restore CD4+ T cell counts, a state known as immunological non-responder (INR) characterized by persistent immune activation and elevated cytokine levels ...
Agnes Rengga Indrati +11 more
doaj +4 more sources
Immune cell subset profiling and metabolic dysregulation define the divergent immune microenvironments in HIV immunological non‐responders [PDF]
Clinical and Translational MedicineBackground A subset of people living with HIV (PLWH) exhibit poor immune recovery despite effective antiretroviral therapy (ART), remaining at risk of disease progression.
Qingfei Chu +6 more
doaj +3 more sources
Elucidating the Gene Signatures and Immune Cell Types in HIV-Infected Immunological Non-Responders by Bioinformatics Analyses [PDF]
International Journal of General Medicine, 2022 Qing Xiao,1,2 Junyan Han,3– 6 Fengting Yu,1– 3 Liting Yan,1,2 Qun Li,1,2 Xiaojie Lao,1,2 Hongxin Zhao,1,2 Fujie Zhang1,2 1Department of Infectious Diseases, Capital Medical University Affiliated Beijing Ditan Hospital, Beijing, People’s Republic of China;
Xiao Q +7 more
doaj +4 more sources
Editorial: Immunological non-responders in HIV infection [PDF]
Frontiers in ImmunologyEvgeniya Saidakova +4 more
doaj +4 more sources
Enhanced Gut-Homing Dynamics and Pronounced Exhaustion of Mucosal and Blood CD4+ T Cells in HIV-Infected Immunological Non-Responders [PDF]
Frontiers in Immunology, 2021 Immunological non-responders (INR), a subgroup of people living with HIV (PLHIV) who fail to restore CD4+ T cell numbers upon effective antiretroviral treatment, have impaired gut mucosal barrier function and an inferior clinical prognosis compared with ...
Kristina Berg Lorvik +19 more
doaj +7 more sources
Association between CD4+ T cell counts and gut microbiota and serum cytokines levels in HIV-infected immunological non-responders [PDF]
BMC Infectious Diseases, 2021 Background CD4+ T cell counts in certain human immunodeficiency virus (HIV)-infected patients called immunological non-responders (INRs) could not return to a normal level even with sustained antiretroviral therapy (ART) because of persistent immune ...
Danfeng Lu +8 more
doaj +5 more sources