Results 11 to 20 of about 26,657 (231)

HIV immunological non-responders are characterized by extensive immunosenescence and impaired lymphocyte cytokine production capacity [PDF]

Frontiers in Immunology
IntroductionImmunological non-responders (INR) are people living with HIV (PLHIV) who fail to fully restore CD4+ T-cell counts despite complete viral suppression with antiretroviral therapy (ART).
Wilhelm A. J. W. Vos, Wilhelm A. J. W. Vos, Adriana Navas, Elise M. G. Meeder, Elise M. G. Meeder, Marc J. T. Blaauw, Marc J. T. Blaauw, Albert L. Groenendijk, Albert L. Groenendijk, Albert L. Groenendijk, Louise E. van Eekeren, Twan Otten, Twan Otten, Nadira Vadaq, Vasiliki Matzaraki, Bram van Cranenbroek, Kees Brinkman, Jan van Lunzen, Leo A. B. Joosten, Leo A. B. Joosten, Mihai G. Netea, Mihai G. Netea, Willem L. Blok, Andre J. A. M. van der Ven, Hans J. P. M. Koenen, Janneke E. Stalenhoef   +25 more
doaj   +6 more sources

Lipoprotein Profile in Immunological Non-Responders PLHIV after Antiretroviral Therapy Initiation. [PDF]

Int J Mol Sci, 2022
Nuclear magnetic resonance (NMR)-based advanced lipoprotein tests have demonstrated that LDL and HDL particle numbers (LDL-P and HDL-P) are more powerful cardiovascular (CV) risk biomarkers than conventional cholesterol markers. Of interest, in people living with HIV (PLHIV), predictors of preclinical atherosclerosis and vascular dysfunction may be ...
Masip J, Jorba R, López-Dupla M, Domingo P, Pacheco YM, García-Pardo G, Martínez E, Viladés C, Veloso S, Alba V, Olona M, Vidal F, Gómez-Bertomeu F, Peraire J, Rull A.   +14 more
europepmc   +7 more sources

Identification of Potential Diagnostic Genes of HIV-Infected Immunological Non-Responders on Bioinformatics Analysis. [PDF]

J Inflamm Res, 2023
HIV-infected immunological non-responders (INRs) failed to achieve the normalization of CD4+ T cell counts despite their undetectable viral load. INRs have an increased risk of clinical progressions of Acquired Immunodeficiency Syndrome (AIDS) and non-AIDS events, accompanied by higher mortality rates than immunological responders (IRs).
Ding Y, Pu C, Zhang X, Tang G, Zhang F, Yu G.   +5 more
europepmc   +5 more sources

Comparative Transcriptional Analysis Identified Characteristic Genes and Patterns in HIV-Infected Immunological Non-Responders. [PDF]

Front Immunol, 2022
PurposeThe incomplete immune reconstitution is a complex phenomenon among human immunodeficiency virus (HIV)-infected patients despite the fact that they have achieved persistent viral suppression under the combined antiretroviral therapy. This study aims to screen and verify the immunological characteristics and underlying mechanisms of immunological ...
Liu X, Lin L, Lu L, Li X, Han Y, Qiu Z, Li X, Li Y, Song X, Cao W, Li T.   +10 more
europepmc   +5 more sources

HIV-Sheltering Platelets From Immunological Non-Responders Induce a Dysfunctional Glycolytic CD4⁺ T-Cell Profile. [PDF]

Front Immunol, 2021
Immunological non-responders (InRs) are HIV-infected individuals in whom the administration of combination antiretroviral therapy (cART), although successful in suppressing viral replication, cannot properly reconstitute patient circulating CD4+ T-cell number to immunocompetent levels.
Zhu A, Real F, Zhu J, Greffe S, de Truchis P, Rouveix E, Bomsel M, Capron C.   +7 more
europepmc   +8 more sources

An atlas of immune cell transcriptomes in human immunodeficiency virus-infected immunological non-responders identified marker genes that control viral replication [PDF]

Chinese Medical Journal, 2023
. Background:. Previous studies have examined the bulk transcriptome of peripheral blood immune cells in acquired immunodeficiency syndrome patients experiencing immunological non-responsiveness.
Yahong Chen, Xin Li, Shuran Liu, Wen Ao, Jing Lin, Zhenting Li, Shouli Wu, Hanhui Ye, Xiao Han, Dongliang Li, Sihan Zhou, Xiuyuan Hao   +11 more
doaj   +2 more sources

Incomplete immune reconstitution in HIV/AIDS patients on antiretroviral therapy: Challenges of immunological non-responders. [PDF]

J Leukoc Biol, 2020
Abstract The morbidity and mortality of HIV type-1 (HIV-1)-related diseases were dramatically diminished by the grounds of the introduction of potent antiretroviral therapy, which induces persistent suppression of HIV-1 replication and gradual recovery of CD4+ T-cell counts.
Yang X, Su B, Zhang X, Liu Y, Wu H, Zhang T.   +5 more
europepmc   +4 more sources

Characteristics and influencing factors of immunological non-responders in HIV-1-infected patients receiving antiretroviral therapy: a cross-sectional study in Guangxi [PDF]

Scientific Reports
The prevalence of AIDS and mortality rates among HIV-infected individuals in Guangxi remain relatively high, potentially due to impaired CD4 + cell recovery. This study aims to identify factors hindering CD4 + cell recovery in people living with HIV.
Xianwu Pang, Qin He, Jinghua Huang, Kailing Tang, Ningye Fang, Haomin Xie, Jie Ma, Qiuying Zhu, Guanghua Lan, Shujia Liang   +9 more
doaj   +2 more sources

Anti-SARS-COV-2 specific immunity in HIV immunological non-responders after mRNA-based COVID-19 vaccination. [PDF]

Front Immunol, 2022
Individuals infected with the human immunodeficiency virus type 1 (HIV-1) belong to the group of people most vulnerable to SARS-CoV-2 infections and the associated disease COVID-19. Here we describe SARS-CoV-2-specific antibody and cellular immune responses in a small cohort of immunological non-responder HIV-1 patients (HIV-INRs) after receiving the ...
Sisteré-Oró M, Andrade N, Wortmann DDJ, Du J, Garcia-Giralt N, González-Cao M, Güerri-Fernández R, Meyerhans A.   +7 more
europepmc   +5 more sources

Metformin may be a viable adjunctive therapeutic option to potentially enhance immune reconstitution in HIV-positive immunological non-responders. [PDF]

Chin Med J (Engl), 2023
Abstract Incomplete immune reconstitution remains a global challenge for human immunodeficiency virus (HIV) treatment in the present era of potent antiretroviral therapy (ART), especially for those individuals referred to as immunological non-responders (INRs), who exhibit dramatically low CD4+ T-cell counts despite the use of ...
Zaongo SD, Chen Y.
europepmc   +4 more sources