Results 21 to 30 of about 26,657 (231)

(5R)-5-hydroxytriptolide for HIV immunological non-responders receiving ART: a randomized, double-blinded, placebo-controlled phase II study. [PDF]

Lancet Reg Health West Pac, 2023
Therapeutic approaches to HIV-suppressed immunological non-responders (INRs) remain unsettled. We previously reported efficacy of Chinese herbal Tripterygium wilfordii Hook F in INRs. Its derivative (5R)-5-hydroxytriptolide (LLDT-8) on CD4 T cell recovery was assessed.The phase II, double-blind, randomized, placebo-controlled trial was conducted in ...
Cao W, Liu X, Han Y, Song X, Lu L, Li X, Lin L, Sun L, Liu A, Zhao H, Han N, Wei H, Cheng J, Zhu B, Wang M, Li Y, Ma P, Gao L, Wang X, Yu J, Zhu T, Routy JP, Zuo M, Li T.   +23 more
europepmc   +3 more sources

Single-cell multi-omics profiling uncovers the immune heterogeneity in HIV-infected immunological non-responders. [PDF]

EBioMedicine
Immunological non-responders (INRs) are people living with HIV-1 who fail to achieve full immune reconstitution despite long-term effective antiretroviral therapy (ART). This incomplete recovery of CD4+ T cells increase the risk of opportunistic infections and non-AIDS-related morbidity and mortality.
Liu X, Zhang L, Li X, Chen L, Lu L, Yang Y, Wu Y, Zheng L, Tang J, Wang F, Han Y, Song X, Cao W, Li T.   +13 more
europepmc   +3 more sources

Increased early activation of CD56dimCD16dim/- natural killer cells in immunological non-responders correlates with CD4+ T-cell recovery. [PDF]

Chin Med J (Engl), 2020
Abstract Background Natural killer (NK) cells play a critical role in suppressing human immunodeficiency virus-1 (HIV-1) infection, but knowledge on whether and how NK cells affect immune reconstitution in HIV-1-infected individuals who receive antiretroviral therapy (ART) is limited.
Zhang QY, Zhang X, Su B, Liu LF, Yang XD, Tang B, Xia H, Ma P, Zhang T, Wu H.   +9 more
europepmc   +4 more sources

Add-on Pyridostigmine Enhances CD4⁺ T-Cell Recovery in HIV-1-Infected Immunological Non-Responders: A Proof-of-Concept Study. [PDF]

Front Immunol, 2017
In human immunodeficiency virus (HIV)-infection, persistent T-cell activation leads to rapid turnover and increased cell death, leading to immune exhaustion and increased susceptibility to opportunistic infections. Stimulation of the vagus nerve increases acetylcholine (ACh) release and modulates inflammation in chronic inflammatory conditions, a ...
Valdés-Ferrer SI, Crispín JC, Belaunzarán-Zamudio PF, Rodríguez-Osorio CA, Cacho-Díaz B, Alcocer-Varela J, Cantú-Brito C, Sierra-Madero J.   +7 more
europepmc   +5 more sources

Markers of CD4⁺ AND CD8⁺ T-cell exhaustion in hiv/hcv coinfected immunological non-responders to antiretroviral therapy

Инфекция и иммунитет
Coinfection with human immunodeficiency virus (HIV) and hepatitis C virus (HCV) is a risk factor for immunological non-response to antiretroviral therapy.
Evgeniya V. Saidakova, L. B. Korolevskaya, V. V. Vlasova, N. G. Shmagel, K. V. Shmagel   +4 more
doaj   +2 more sources

Impact of extended-release niacin on immune activation in HIV-infected immunological non-responders on effective antiretroviral therapy

HIV Research & Clinical Practice, 2020
Background Background: Tryptophan (Trp) catabolism into immunosuppressive kynurenine (Kyn) is involved in immune dysregulation during HIV infection. Niacin (vitamin B3) could control the excess of tryptophan depletion and represents a potential strategy ...
Bertrand Lebouché, Alexis Yero, Tao Shi, Omar Farnos, Joel Singer, Ido Kema, Cecilia T. Costiniuk, Réjean Thomas, Marie-Josée Brouillette, Kim Engler, Jean-Pierre Routy, Mohammad-Ali Jenabian, for the CTN PT006 Study Group   +12 more
doaj   +4 more sources

Oral Microbiota Is Associated With Immune Recovery in Human Immunodeficiency Virus-Infected Individuals

Frontiers in Microbiology, 2021
The role of the oral microbiota in HIV-infected individuals deserves attention as either HIV infection or antiretroviral therapy (ART) may have effect on the diversity and the composition of the oral microbiome.
Yirui Xie, Jia Sun, Caiqin Hu, Bing Ruan, Biao Zhu   +4 more
doaj   +1 more source

Immunologic hypo- or non-responder in natural dengue virus infection [PDF]

Journal of Biomedical Science, 2013
Serologically defined primary dengue virus infection and/or subsequent homologous serotype infection is known to be associated with less severe disease as compared with secondary subsequent heterologous serotype infection. In geographical locales of high dengue endemicity, almost all individuals in the population are infected at some point in time and ...
Guey‐Chuen Perng, Kulkanya Chokephaibulkit   +1 more
openaire   +2 more sources

Altered gut microbiota correlate with different immune responses to HAART in HIV-infected individuals

BMC Microbiology, 2021
Background Although gut microbiota dysbiosis has been reported in HIV infected individuals recently, the relationship between the gut microbiota and immune activation in patients with different immune responses to highly active antiretroviral therapy ...
Yirui Xie, Jia Sun, Li Wei, Haiyin Jiang, Caiqin Hu, Jiezuan Yang, Ying Huang, Bing Ruan, Biao Zhu   +8 more
doaj   +1 more source

Plasma MicroRNA Signature Panel Predicts the Immune Response After Antiretroviral Therapy in HIV-Infected Patients

Frontiers in Immunology, 2021
BackgroundApproximately 10–40% of people with human immunodeficiency virus (HIV) infection are unable to obtain successful improvements in immune function after antiretroviral therapy (ART).
Jun-Nan Lv, Jun-Nan Lv, Jia-Qi Li, Jia-Qi Li, Ying-Bin Cui, Yuan-Yuan Ren, Yuan-Yuan Ren, Ya-Jing Fu, Ya-Jing Fu, Yong-Jun Jiang, Yong-Jun Jiang, Hong Shang, Hong Shang, Zi-Ning Zhang, Zi-Ning Zhang   +14 more
doaj   +1 more source