Results 61 to 70 of about 26,657 (231)

Impact of long-term viral suppression in CD4+ recovery of HIV-children on Highly Active Antiretroviral Therapy

BMC Infectious Diseases, 2006
Background The effects of HAART may differ between children and adults because children have a developing immune system, and the long-term immunological outcome in HIV-infected children on HAART is not well-known.
Gurbindo-Gutierrez Dolores, Ramos Jose T, Martin-Fontelos Pablo, Bellon José M, Leon Juan A, Resino Rosa, Resino Salvador, de Jose Maria I, Ciria Luis, Muñoz-Fernandez Maria A   +9 more
doaj   +1 more source

Immunological Review on Non-responder Phenomenon to Hepatitis B Vaccination

Cermin Dunia Kedokteran
Hepatitis B vaccine has been highly effective in preventing HBV infection. However, a subset of individuals fails to develop adequate protective antibodies after complete vaccination series (anti-HBs ≥ 10 mIU/mL), termed as non-responders. Non-responder phenomenon is influenced by a complex interplay of genetic, immunological, and environmental factors.
Adika Zhulhi Arjana, Ninda Devita
openaire   +1 more source

Activated/Cycling Treg Deficiency and Mitochondrial Alterations in Immunological Non-Responders to Antiretroviral Therapy

Frontiers in Bioscience-Landmark
Background: Regulatory T-cells (Tregs) play a crucial role in maintaining immune homeostasis, but their dynamics are altered in a subset of people living with Human Immunodeficiency Virus (HIV) known as immunological non-responders (INRs). INRs fail to reconstitute CD4+ T-cell counts despite viral suppression.
Souheil-Antoine Younes, Violetta Vlasova, Larisa Korolevskaya, Evgeniya Saidakova, Konstantin Shmagel   +4 more
openaire   +3 more sources

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Establishment of a coculture system for Porphyromonas gingivalis and head and neck squamous cell carcinoma using spheroid culture and LATS inhibition

FEBS Open Bio, EarlyView.
We established a spheroid coculture system enabling viable Porphyromonas gingivalis–HNSCC interactions under normoxic conditions. Inhibition of LATS1/2 maintains tumor cells in an undifferentiated state, which may promote spheroid growth and create a more permissive environment for bacterial persistence.
Yurika Nakajima, Shogo Okazaki, Muneaki Tamura, Shuichi Sato, Kenichi Imai   +4 more
wiley   +1 more source

Prevalence of and prognosis for poor immunological recovery by virally suppressed and aged HIV-infected patients

Frontiers in Medicine, 2023
BackgroundAntiretroviral therapy (ART) prolongs lifespan and decreases mortality of HIV infected patients. However, many patients do not achieve optimal immune reconstitution.
Lina Fan, Penghui Li, Aiping Yu, Dan Liu, Ziyu Wang, Yue Wu, Yue Wu, Defa Zhang, Defa Zhang, Meiyin Zou, Ping Ma, Ping Ma   +11 more
doaj   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

Response assessment of GBM during immunotherapy by delayed contrast treatment response assessment maps

Frontiers in Neurology
IntroductionAssessing the treatment response of glioblastoma multiforme during immunotherapy (IT) is an open issue. Treatment response assessment maps (TRAMs) might help distinguish true tumor progression (TTP) and pseudoprogression (PsP) in this setting.
Valeria Cuccarini, Filippo Savoldi, Yael Mardor, Yael Mardor, David Last, Serena Pellegatta, Federica Mazzi, Maria Grazia Bruzzone, Elena Anghileri, Bianca Pollo, Luisa Maddaloni, Camilla Russo, Elisa Bocchi, Valentina Pinzi, Marica Eoli, Domenico Aquino   +15 more
doaj   +1 more source

Stimulation of PBMC and Monocyte-derived-Macrophages via Toll-Like Receptor (TLRs) Activates Innate Immune Pathways in HIV-Infected Patients on Virally-Suppressive Combination Antiretroviral Therapy (cART)

Frontiers in Immunology, 2016
In HIV-infected cART-treated patients, immune activation and microbial translocation persist and associate with inadequate CD4 recovery and morbidity/mortality.
Esther Merlini, Camilla Tincati, Mara Biasin, Irma Saulle, Federico Angelo Cazzaniga, Antonella d'Arminio Monforte, Amedeo J Cappione, Jennifer Snyder-Cappione, Mario (Mago) Clerici, Mario (Mago) Clerici, Giulia Carla Marchetti   +10 more
doaj   +1 more source

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source