Results 21 to 30 of about 109,666 (292)

DREIMT: a drug repositioning database and prioritization tool for immunomodulation [PDF]

, 2020
Drug immunomodulation modifies the response of the immune system and can be therapeutically exploited in pathologies such as cancer and autoimmune diseases.
Martorell-Marugán, Jordi, Jordi Martorell-Marugán, Carmona-Sáez, Pedro, Al-Shahrour, Fátima, Martín-Serrano, Guillermo, Miguel Reboiro-Jato, Reboiro-Jato, Miguel, Gómez-López, Gonzalo, Kevin Troulé, Guillermo Martín-Serrano, Gonzalo Gómez-López, Troulé, Kevin, López-Fernández, Hugo, Santiago García-Martín, Carretero-Puche, Carlos, Pedro Carmona-Sáez, Hugo López-Fernández, García-Martín, Santiago, Glez-Peña, Daniel, Daniel Glez-Peña, Carlos Carretero-Puche, Fátima Al-Shahrour   +21 more
core   +2 more sources

Phages and Immunomodulation [PDF]

Future Microbiology, 2017
In the past years, the microbiome and its role in the pathophysiology of diseases have gained great interest. The progress of our knowledge in this field opens completely novel prospects for treating disorders, including those which are most challenging to medicine today.
Andrzej Górski, Dąbrowska, Krystyna, Ryszard Andrzej Międzybrodzki, Weber-Dąbrowska, Beata, Łusiak-Szelachowska, Marzanna, Jończyk-Matysiak, Ewa, Jan Jakub Borysowski   +6 more
openaire   +2 more sources

Unsupervised title and abstract screening for systematic review: a retrospective case-study using topic modelling methodology

Systematic Reviews, 2023
Background The importance of systematic reviews in collating and summarising available research output on a particular topic cannot be over-emphasized.
Agnes Natukunda, Leacky K. Muchene
doaj   +1 more source

Ethical and practical considerations arising from community consultation on implementing controlled human infection studies using Schistosoma mansoni in Uganda

Global Bioethics, 2022
Issues related to controlled human infection studies using Schistosoma mansoni (CHI-S) were explored to ensure the ethical and voluntary participation of potential CHI-S volunteers in an endemic setting in Uganda.
Moses Egesa, Agnes Ssali, Edward Tumwesige, Moses Kizza, Emmanuella Driciru, Fiona Luboga, Meta Roestenberg, Janet Seeley, Alison M. Elliott   +8 more
doaj   +1 more source

Effect of birth weight, exclusive breastfeeding and growth in infancy on fat mass and fat free mass indices in early adolescence: an analysis of the Entebbe Mother and Baby Study (EMaBs) cohort [version 1; peer review: 1 approved, 2 approved with reservations]

AAS Open Research, 2019
Background: There is limited data from Africa on the effect of pre- and post-natal growth and infant feeding on later body composition. This study's aim was to investigate the effect of birth weight, exclusive breastfeeding and infant growth on ...
Jonathan Nsamba, Swaib A. Lule, Benigna Namara, Christopher Zziwa, Hellen Akurut, Lawrence Lubyayi, Florence Akello, Josephine Tumusiime, Alison M. Elliott, Emily L. Webb   +9 more
doaj   +1 more source

Contrasting impact of rural, versus urban, living on glucose metabolism and blood pressure in Uganda [version 2; peer review: 2 approved]

Wellcome Open Research, 2020
Background: The burden of cardiometabolic diseases, including cardiovascular diseases and diabetes, is increasing in sub-Saharan Africa and this has been linked to urbanisation.
Richard E. Sanya, Irene Andia Biraro, Margaret Nampijja, Christopher Zziwa, Carol Nanyunja, Denis Nsubuga, Samuel Kiwanuka, Josephine Tumusiime, Jacent Nassuuna, Bridgious Walusimbi, Stephen Cose, Ponsiano Ocama, Richard K. Grencis, Alison M. Elliott, Emily L. Webb   +14 more
doaj   +1 more source

The Role of Immune Cells in Post-Stroke Angiogenesis and Neuronal Remodeling: The Known and the Unknown

Frontiers in Immunology, 2021
Following a cerebral ischemic event, substantial alterations in both cellular and molecular activities occur due to ischemia-induced cerebral pathology.
Yinzhong Ma, Shilun Yang, Qianyan He, Dianhui Zhang, Junlei Chang   +4 more
doaj   +1 more source

Functional systemic CD4 immunity is required for clinical responses to PD‐L1/PD‐1 blockade therapy

EMBO Molecular Medicine, 2019
The majority of lung cancer patients progressing from conventional therapies are refractory to PD‐L1/PD‐1 blockade monotherapy. Here, we show that baseline systemic CD4 immunity is a differential factor for clinical responses.
Miren Zuazo, Hugo Arasanz, Gonzalo Fernández‐Hinojal, Maria Jesus García‐Granda, María Gato, Ana Bocanegra, Maite Martínez, Berta Hernández, Lucía Teijeira, Idoia Morilla, Maria Jose Lecumberri, Angela Fernández de Lascoiti, Ruth Vera, Grazyna Kochan, David Escors   +14 more
doaj   +1 more source

Maternal Latent Mycobacterium tuberculosis Does Not Affect the Infant Immune Response Following BCG at Birth: An Observational Longitudinal Study in Uganda

Frontiers in Immunology, 2020
Background: BCG has low efficacy in tropical countries. We hypothesized that maternal latent Mycobacterium tuberculosis (M.tb) infection (LTBI) results in fetal tolerance to mycobacterial antigens and impaired responses to BCG immunization.Methods: We ...
Lawrence Lubyayi, Lawrence Lubyayi, Patrice A. Mawa, Patrice A. Mawa, Grace Nabakooza, Marjorie Nakibuule, John Vianney Tushabe, Joel Serubanja, Dorothy Aibo, Hellen Akurut, Josephine Tumusiime, Mateusz Hasso-Agopsowicz, Pontiano Kaleebu, Pontiano Kaleebu, Jonathan Levin, Hazel M. Dockrell, Steven Smith, Emily L. Webb, Alison M. Elliott, Alison M. Elliott, Stephen Cose, Stephen Cose   +21 more
doaj   +1 more source

Polydopamine-Mediated Protein Adsorption Alters the Epigenetic Status and Differentiation of Primary Human Adipose-Derived Stem Cells (hASCs)

Frontiers in Bioengineering and Biotechnology, 2022
Polydopamine (PDA) is a biocompatible cell-adhesive polymer with versatile applications in biomedical devices. Previous studies have shown that PDA coating could improve cell adhesion and differentiation of human mesenchymal stem cells (hMSCs).
Javad Harati, Javad Harati, Javad Harati, Xuelian Tao, Hosein Shahsavarani, Ping Du, Massimiliano Galluzzi, Kun Liu, Zhen Zhang, Zhen Zhang, Peter Shaw, Mohammad Ali Shokrgozar, Haobo Pan, Peng-Yuan Wang, Peng-Yuan Wang   +14 more
doaj   +1 more source