Results 21 to 30 of about 96,912 (310)

Dissecting the role of CSF2RB expression in human regulatory T cells

Frontiers in Immunology, 2022
Colony stimulating factor 2 receptor subunit beta (CSF2RB; CD131) is the common subunit of the type I cytokine receptors for granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin (IL)-3 and IL-5. Interestingly, FOXP3+ regulatory T cells (
Beatriz F. Côrte-Real, Beatriz F. Côrte-Real, Rebeca Arroyo Hornero, Rebeca Arroyo Hornero, Aleksandra Dyczko, Aleksandra Dyczko, Ibrahim Hamad, Ibrahim Hamad, Markus Kleinewietfeld, Markus Kleinewietfeld, Markus Kleinewietfeld   +10 more
doaj   +1 more source

Pre-therapeutic microglia activation and sex determine therapy effects of chronic immunomodulation. [PDF]

, 2021
Modulation of the innate immune system is emerging as a promising therapeutic strategy against Alzheimer's disease (AD). However, determinants of a beneficial therapeutic effect are ill-understood.
Focke, Carola, Willem, Michael, Kleinberger, Gernot, Dorostkar, Mario M, Franzmeier, Nicolai, Blume, Tanja, Schmidt, Claudio, Sacher, Christian, von Ungern-Sternberg, Barbara, Herms, Jochen, Xiang, Xianyuan, Gildehaus, Franz-Josef, Biechele, Gloria, Cumming, Paul, Adelsberger, Helmuth, Rominger, Axel, Ungern-Sternberg, Barbara von, Brendel, Matthias, Shi, Yuan, Dorostkar, Mario M., Peters, Finn, Eckenweber, Florian, Beyer, Leonie, Wind, Karin, Ochs, Katharina, Baumann, Karlheinz, Zott, Benedikt, Deussing, Maximilian, Lindner, Simon, Bartenstein, Peter   +29 more
core   +1 more source

DREIMT: a drug repositioning database and prioritization tool for immunomodulation [PDF]

, 2020
Drug immunomodulation modifies the response of the immune system and can be therapeutically exploited in pathologies such as cancer and autoimmune diseases.
Martorell-Marugán, Jordi, Jordi Martorell-Marugán, Carmona-Sáez, Pedro, Al-Shahrour, Fátima, Martín-Serrano, Guillermo, Miguel Reboiro-Jato, Reboiro-Jato, Miguel, Gómez-López, Gonzalo, Kevin Troulé, Guillermo Martín-Serrano, Gonzalo Gómez-López, Troulé, Kevin, López-Fernández, Hugo, Santiago García-Martín, Carretero-Puche, Carlos, Pedro Carmona-Sáez, Hugo López-Fernández, García-Martín, Santiago, Glez-Peña, Daniel, Daniel Glez-Peña, Carlos Carretero-Puche, Fátima Al-Shahrour   +21 more
core   +2 more sources

Unsupervised title and abstract screening for systematic review: a retrospective case-study using topic modelling methodology

Systematic Reviews, 2023
Background The importance of systematic reviews in collating and summarising available research output on a particular topic cannot be over-emphasized.
Agnes Natukunda, Leacky K. Muchene
doaj   +1 more source

Anti-COVID-19 drug candidates: A review on potential biological activities of natural products in the management of new coronavirus infection

Journal of Traditional and Complementary Medicine, 2021
Background and aim: The novel coronavirus disease (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is now become a worldwide pandemic bringing over 71 million confirmed cases, while the specific drugs and vaccines ...
Anchalee Prasansuklab, Atsadang Theerasri, Panthakarn Rangsinth, Chanin Sillapachaiyaporn, Siriporn Chuchawankul, Tewin Tencomnao   +5 more
doaj   +1 more source

Ethical and practical considerations arising from community consultation on implementing controlled human infection studies using Schistosoma mansoni in Uganda

Global Bioethics, 2022
Issues related to controlled human infection studies using Schistosoma mansoni (CHI-S) were explored to ensure the ethical and voluntary participation of potential CHI-S volunteers in an endemic setting in Uganda.
Moses Egesa, Agnes Ssali, Edward Tumwesige, Moses Kizza, Emmanuella Driciru, Fiona Luboga, Meta Roestenberg, Janet Seeley, Alison M. Elliott   +8 more
doaj   +1 more source

Effect of birth weight, exclusive breastfeeding and growth in infancy on fat mass and fat free mass indices in early adolescence: an analysis of the Entebbe Mother and Baby Study (EMaBs) cohort [version 1; peer review: 1 approved, 2 approved with reservations]

AAS Open Research, 2019
Background: There is limited data from Africa on the effect of pre- and post-natal growth and infant feeding on later body composition. This study's aim was to investigate the effect of birth weight, exclusive breastfeeding and infant growth on ...
Jonathan Nsamba, Swaib A. Lule, Benigna Namara, Christopher Zziwa, Hellen Akurut, Lawrence Lubyayi, Florence Akello, Josephine Tumusiime, Alison M. Elliott, Emily L. Webb   +9 more
doaj   +1 more source

Contrasting impact of rural, versus urban, living on glucose metabolism and blood pressure in Uganda [version 2; peer review: 2 approved]

Wellcome Open Research, 2020
Background: The burden of cardiometabolic diseases, including cardiovascular diseases and diabetes, is increasing in sub-Saharan Africa and this has been linked to urbanisation.
Richard E. Sanya, Irene Andia Biraro, Margaret Nampijja, Christopher Zziwa, Carol Nanyunja, Denis Nsubuga, Samuel Kiwanuka, Josephine Tumusiime, Jacent Nassuuna, Bridgious Walusimbi, Stephen Cose, Ponsiano Ocama, Richard K. Grencis, Alison M. Elliott, Emily L. Webb   +14 more
doaj   +1 more source

Polydopamine-Mediated Protein Adsorption Alters the Epigenetic Status and Differentiation of Primary Human Adipose-Derived Stem Cells (hASCs)

Frontiers in Bioengineering and Biotechnology, 2022
Polydopamine (PDA) is a biocompatible cell-adhesive polymer with versatile applications in biomedical devices. Previous studies have shown that PDA coating could improve cell adhesion and differentiation of human mesenchymal stem cells (hMSCs).
Javad Harati, Javad Harati, Javad Harati, Xuelian Tao, Hosein Shahsavarani, Ping Du, Massimiliano Galluzzi, Kun Liu, Zhen Zhang, Zhen Zhang, Peter Shaw, Mohammad Ali Shokrgozar, Haobo Pan, Peng-Yuan Wang, Peng-Yuan Wang   +14 more
doaj   +1 more source

Skin Immunomodulation during Regeneration: Emerging New Targets

, 2021
Adipose-Derived Stem Cells (ADSC) are present within the hypodermis and are also expected to play a pivotal role in wound healing, immunomodulation, and rejuvenation activities.
Gabriel Malka, Yousra Hamdan, Luc Rochette, Loubna Mazini   +3 more
core   +1 more source