Results 31 to 40 of about 96,912 (310)

Maternal Latent Mycobacterium tuberculosis Does Not Affect the Infant Immune Response Following BCG at Birth: An Observational Longitudinal Study in Uganda

Frontiers in Immunology, 2020
Background: BCG has low efficacy in tropical countries. We hypothesized that maternal latent Mycobacterium tuberculosis (M.tb) infection (LTBI) results in fetal tolerance to mycobacterial antigens and impaired responses to BCG immunization.Methods: We ...
Lawrence Lubyayi, Lawrence Lubyayi, Patrice A. Mawa, Patrice A. Mawa, Grace Nabakooza, Marjorie Nakibuule, John Vianney Tushabe, Joel Serubanja, Dorothy Aibo, Hellen Akurut, Josephine Tumusiime, Mateusz Hasso-Agopsowicz, Pontiano Kaleebu, Pontiano Kaleebu, Jonathan Levin, Hazel M. Dockrell, Steven Smith, Emily L. Webb, Alison M. Elliott, Alison M. Elliott, Stephen Cose, Stephen Cose   +21 more
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Functional systemic CD4 immunity is required for clinical responses to PD‐L1/PD‐1 blockade therapy

EMBO Molecular Medicine, 2019
The majority of lung cancer patients progressing from conventional therapies are refractory to PD‐L1/PD‐1 blockade monotherapy. Here, we show that baseline systemic CD4 immunity is a differential factor for clinical responses.
Miren Zuazo, Hugo Arasanz, Gonzalo Fernández‐Hinojal, Maria Jesus García‐Granda, María Gato, Ana Bocanegra, Maite Martínez, Berta Hernández, Lucía Teijeira, Idoia Morilla, Maria Jose Lecumberri, Angela Fernández de Lascoiti, Ruth Vera, Grazyna Kochan, David Escors   +14 more
doaj   +1 more source

Fast and Efficient Genome Editing of Human FOXP3+ Regulatory T Cells

Frontiers in Immunology, 2021
FOXP3+ regulatory T cells (Tregs) are central for maintaining peripheral tolerance and immune homeostasis. Because of their immunosuppressive characteristics, Tregs are a potential therapeutic target in various diseases such as autoimmunity ...
Lauren Van Zeebroeck, Lauren Van Zeebroeck, Rebeca Arroyo Hornero, Rebeca Arroyo Hornero, Beatriz F. Côrte-Real, Beatriz F. Côrte-Real, Ibrahim Hamad, Ibrahim Hamad, Torsten B. Meissner, Markus Kleinewietfeld, Markus Kleinewietfeld   +10 more
doaj   +1 more source

Selenium Nanoparticles (SeNPs) Immunomodulation Is More Than Redox Improvement: Serum Proteomics and Transcriptomic Analyses [PDF]

, 2022
Selenium nanoparticles (SeNPs) are a novel elemental form selenium and often reported to possess beneficial bioactivities such as anticancer, promoting bone growth and immunomodulation.
Lu, Yishan, Yishan Lu, Xia, Ivan Fan, Kevin W. H. Kwok, Wong, KH, Hang-Kin Kong, Margaret M. H. Wu, Kong, Hang-Kin, Wong, Ka-Hing, Ka-Hing Wong, Wu, Margaret M. H., Kong, HK, Wu, MMH, Ivan Fan Xia, Lu, Y, Xia, IF, Kwok, Kevin W. H., Kwok, KWH   +17 more
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Metabolic Reconfiguration Activates Stemness and Immunomodulation of PDLSCs

, 2022
Periodontal ligament derived stem cells (PDLSC) are adult multipotent mesenchymal-like stem cells (MSCs) that can induce a promising immunomodulation to interact with immune cells for disease treatment.
Wenjing Yu, Ranran Huang, Chider Chen, Wen Li, Payal Arora, Qian Jiang, Xiaobin Huang   +6 more
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Development, Characterization, and Immunomodulatory Evaluation of Carvacrol-loaded Nanoemulsion

Molecules, 2021
Carvacrol (CV) is an essential oil with numerous therapeutic properties, including immunomodulatory activity. However, this effect has not been studied in nanoemulsion systems.
Amanda Gabrielle Barros Dantas, Rafael Limongi de Souza, Anderson Rodrigues de Almeida, Francisco Humberto Xavier Júnior, Maira Galdino da Rocha Pitta, Moacyr Jesus Barreto de Melo Rêgo, Elquio Eleamen Oliveira   +6 more
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Knowledge Mapping of Opioids and Immunomodulation: A Bibliometric Analysis (2000–2022)

, 2023
Subinuer Kurexi,1 Ke Wang,2 Tongyu Chen1 1Department of Cardiothoracic Surgery, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, People’s Republic of China ...
Kurexi S, Wang K, Chen T
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Transfusion-transmissible infections and transfusion-related immunomodulation [PDF]

, 2008
The risk of acquiring a transfusion-transmitted infection has declined in recent years. However, after human immunodeficiency virus and hepatitis B and C virus transmission were successfully reduced, new pathogens are threatening the safety of the blood ...
Beck-Schimmer, B, Spahn, D R, Felix Buddeberg, Beatrice Beck Schimmer, Donat R. Spahn, Buddeberg, F   +5 more
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Bifidobacteria BbC50 Fermentation Products Induce Human Cd4 Regulatory T Cells with Antigen-Specific Activation and Bystander Suppression

European Journal of Inflammation, 2014
Probiotic bacteria have been shown to have health benefits in various situations (inflammation, allergy, infection). We previously showed that a bacteria-free fermentation product of Bifidobacterium breve C50 (BbC50sn) induced high IL-10 secretion by ...
L. Martin, A. Granier, R. Lemoine, A. Dauba, S. Vermeersch, C. Aubert-Jacquin, C. Baron, Y. Lebranchu, C. Hoarau, F. Velge-Roussel   +9 more
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Immunosuppression and Immunomodulation

, 2023
This book synthesizes the key concepts of immunosuppression and immunomodulation. A comprehensive understanding of these processes is necessary to develop vaccines and therapeutic interventions for diseases.

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