Results 61 to 70 of about 74,853 (208)

Modeling the Dichotomy of the Immune Response to Cancer: Cytotoxic Effects and Tumor-Promoting Inflammation [PDF]

arXiv, 2013
Although the immune response is often regarded as acting to suppress tumor growth, it is now clear that it can be both stimulatory and inhibitory. The interplay between these competing influences has complex implications for tumor development and cancer dormancy.
arxiv  

The Upregulation of Toll-Like Receptor 3 via Autocrine IFN-β Signaling Drives the Senescence of Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells Through JAK1

Frontiers in Immunology, 2019
Although mesenchymal stromal cells (MSCs) are among the most promising cell sources for cell-based therapies and regenerative medicine, the decline in their function with age due to cellular senescence limits their therapeutic applications. Unveiling the
Hyang Ju Lee, Hyang Ju Lee, Bongkun Choi, Bongkun Choi, Yongsub Kim, Yongsub Kim, Sang Eun Lee, Sang Eun Lee, Hye Jin Jin, Hee-Seop Lee, Hee-Seop Lee, Eun-Ju Chang, Eun-Ju Chang, Eun-Ju Chang, Seong Who Kim, Seong Who Kim   +15 more
doaj   +1 more source

Main lesions in the central nervous system of dogs due to Leishmania infantum infection

BMC Veterinary Research, 2017
Background Canine visceral leishmaniasis (CVL) is endemic in São Luís Maranhão/Brazil and it leads a varied clinical picture, including neurological signs.
Weline Lopes Macau, Joicy Cortez de Sá, Ana Patrícia de Carvalho da Silva, Alessandra Lima Rocha, Renata Mondêgo-Oliveira, Fábio Henrique Evangelista de Andrade, Caroline Magalhães Cunha, Kátia da Silva Calabrese, Ana Lucia Abreu-Silva   +8 more
doaj   +1 more source

High Salt Inhibits Tumor Growth by Enhancing Anti-tumor Immunity

Frontiers in Immunology, 2019
Excess salt intake could affect the immune system by shifting the immune cell balance toward a pro-inflammatory state. Since this shift of the immune balance is thought to be beneficial in anti-cancer immunity, we tested the impact of high salt diets on ...
Ralf Willebrand, Ibrahim Hamad, Lauren Van Zeebroeck, Máté Kiss, Máté Kiss, Kirsten Bruderek, Anneleen Geuzens, Dries Swinnen, Beatriz Fernandes Côrte-Real, Lajos Markó, Els Lebegge, Els Lebegge, Damya Laoui, Damya Laoui, Josephine Kemna, Josephine Kemna, Thomas Kammertoens, Thomas Kammertoens, Sven Brandau, Jo A. Van Ginderachter, Jo A. Van Ginderachter, Markus Kleinewietfeld   +21 more
doaj   +1 more source

Elevated Neuropeptide Y in Endothelial Dysfunction Promotes Macrophage Infiltration and Smooth Muscle Foam Cell Formation

Frontiers in Immunology, 2019
Endothelial dysfunction has been linked to vascular inflammation and foam cell formation but the underlying mechanisms still remain unclear. We sought to define the factors inducing inflammation and smooth muscle foam cell formation under endothelial ...
Bongkun Choi, Bongkun Choi, Min-Kyung Shin, Min-Kyung Shin, Eun-Young Kim, Eun-Young Kim, Ji-Eun Park, Ji-Eun Park, Halim Lee, Seong Who Kim, Seong Who Kim, Jae-Kwan Song, Eun-Ju Chang, Eun-Ju Chang, Eun-Ju Chang   +14 more
doaj   +1 more source

Stochastic Mathematical Modelling Study for Understanding the Extinction, Persistence and Control of SARS-CoV-2 Virus at the Within-host Level [PDF]

arXiv
Stochastic differential equations characterized by uncertainty are effective in modelling virus dynamics and provide an alternative to traditional deterministic models. Epidemic models are inevitably subjected to the randomness within the system or the environmental noise.
arxiv  

Natural Immunomodulators [PDF]

Journal of Immunology Research, 2017
D. Ortuño-Sahagún, K. Zänker, A. K. S. Rawat, S. V. Kaveri, P. Hegde   +4 more
openaire   +3 more sources

Application of Single-cell Deep Learning in Elucidating the Mapping Relationship Between Visceral and Body Surface Inflammatory Patterns [PDF]

arXiv
As a system of integrated homeostasis, life is susceptible to disruptions by visceral inflammation, which can disturb internal environment equilibrium. The role of body-spread subcutaneous fascia (scFascia) in this process is poorly understood. In the rat model of Salmonella-induced dysentery, scRNA-seq of scFascia and deep-learning analysis revealed ...
arxiv  

Human platelet lysate enhances small lipid droplet accumulation of human MSCs through MAPK phosphorylation

Stem Cell Research & Therapy
Background Human platelet lysate (hPL) has emerged as a promising serum substitute to enhance the self-renewal and multipotency of human mesenchymal stem cells (MSCs).
Ping Du, Xuelian Tao, Javad Harati, Yue Shi, Liang Xiao, Xian Li, Haobo Pan, Peng-Yuan Wang   +7 more
doaj   +1 more source

Immunological mechanisms and immunoregulatory strategies in intervertebral disc degeneration [PDF]

arXiv
Intervertebral discs are avascular and maintain immune privilege. However, during intervertebral disc degeneration (IDD), this barrier is disrupted, leading to extensive immune cell infiltration and localized inflammation. In degenerated discs, macrophages, T lymphocytes, neutrophils, and granulocytic myeloid-derived suppressor cells (G-MDSCs) are key ...
arxiv