Results 101 to 110 of about 2,997 (217)

Microfluidic-Based F-Labeling of Biomolecules for Immuno–Positron Emission Tomography

Molecular Imaging, 2011
Methods for tagging biomolecules with fluorine 18 as immuno–positron emission tomography (immunoPET) tracers require tedious optimization of radiolabeling conditions and can consume large amounts of scarce biomolecules.
Kan Liu, Eric J. Lepin, Ming-Wei Wang, Feng Guo, Wei-Yu Lin, Yi-Chun Chen, Shannon J. Sirk, Sebastian Olma, Michael E. Phelps, Xing-Zhong Zhao, Hsian-Rong Tseng, R. Michael van Dam, Anna M. Wu, Clifton K.-F. Shen   +13 more
doaj   +1 more source

Excitation functions for (p,x) reactions of niobium in the energy range of E$_{\text{p}}$ = 40-90 MeV [PDF]

, 2018
A stack of thin Nb foils was irradiated with the 100 MeV proton beam at Los Alamos National Laboratory's Isotope Production Facility, to investigate the $^{93}$Nb(p,4n)$^{90}$Mo nuclear reaction as a monitor for intermediate energy proton experiments and
Bernstein, Lee A., Birnbaum, Eva R., Engle, Jonathan W., Graves, Stephen A., Kawano, Toshihiko, Lewis, Amanda M., Nortier, Francois M., Voyles, Andrew S.   +7 more
core   +2 more sources

Visualization of the Spiral Ganglion Neuron in Vivo Using a Novel 177Lu Nuclear Molecule Label

Advanced Science, Volume 12, Issue 29, August 7, 2025.
The study developed and validated a radionuclide‐labeled anti‐VGLUT1 antibody probe for the first nuclear imaging of cochlear spiral ganglion neurons (SGNs) in vivo. This approach may provide aid in screening candidates suitable for CI surgery by quantifying the number of surviving SGNs, and predicting the potential for postoperative hearing ...
Chenyang Kong, Xiaohui Wang, Jintao Yu, Li Wen, Chengwen Zheng, Ge Yin, Kai Xu, Weiwei He, Hao Wang, Xiaoli Lan, Dawei Jiang, Yu Sun   +11 more
wiley   +1 more source

Maintaining lung health with longstanding HIV [PDF]

, 2016
Purpose of review: Human immunodeficiency virus (HIV) is now managed as a chronic disease. Non-infectious pulmonary conditions have replaced infection as the biggest threat to lung health, particularly as HIV cohorts age, but there is no consensus on how
Aberg, Almodovar, Amsellem, Araujo, Attia, Aukrust, Borges, Boutten, Buhl, Buzon, Caldwell, Cicalini, Clausen, Coghill, Correale, Cota-Gomez, Cribbs, Cribbs, Crothers, Crothers, Crothers, Cui, Currier, Dalvi, Dalvi, Degano, Diaz, Diaz, Diaz, Diaz, Drummond, Engels, Fan, Feijoo, Fisher, Fishman, Fitzpatrick, George, George, Gingo, Gingo, Gingo, Gingo, Green, Guiguet, Gundavarapu, Helleberg, Hirani, Hodge, Hogg, Horiike, Hulbert, Isasti, Kanmogne, Kanmogne, Kirk, Kristoffersen, Lambert, Lassiter, Leung, Liu, Lozupone, Madeddu, Makinson, Marcus, Marecki, McQuillan, Mermis, Mitchell, Morris, National Lung Screening Trial Research, Opravil, Opravil, Pacht, Parikh, Patel, Peacock, Pefura-Yone, Popescu, Porter, Quezada, Reekie, Reinsch, Rosen, Samperiz, Sangal, Santangelo, Schwarcz, Schwarze-Zander, Secemsky, Selby, Sharma, Shebl, Sheth, Shiels, Shiels, Shirley, Sigel, Sigel, Sitbon, Speich, Sze, Tcherakian, ten Freyhaus, Vandenhende, Wanchu, Worm, Yearsley, Zheng   +108 more
core   +1 more source

ImmunoPET Imaging of Endogenous and Transfected Prolactin Receptor Tumor Xenografts [PDF]

Molecular Pharmaceutics, 2018
Antibodies labeled with positron-emitting isotopes have been used for tumor detection, predicting which patients may respond to tumor antigen-directed therapy, and assessing pharmacodynamic effects of drug interventions. Prolactin receptor (PRLR) is overexpressed in breast and prostate cancers and is a new target for cancer therapy.
Sarah M. Cheal, Shutian Ruan, Darren R. Veach, Valerie A. Longo, Blesida J. Punzalan, Jiong Wu, Edward K. Fung, Marcus P. Kelly, Jessica R. Kirshner, Jason T. Giurleo, George Ehrlich, Amy Q. Han, Gavin Thurston, William C. Olson, Pat B. Zanzonico, Steven M. Larson, Jorge A. Carrasquillo   +16 more
openaire   +2 more sources

ImmunoPET imaging of human CD8+ T cells with novel 68Ga-labeled nanobody companion diagnostic agents

Journal of Nanobiotechnology, 2021
Background Although immunotherapy has revolutionized treatment strategies for some types of cancers, most patients failed to respond or obtain long-term benefit.
Haitao Zhao, Chao Wang, Yanling Yang, Yan Sun, Weijun Wei, Cheng Wang, Liangrong Wan, Cheng Zhu, Lianghua Li, Gang Huang, Jianjun Liu   +10 more
doaj   +1 more source

Fluorine-18 ImmunoPET Imaging of Antibody Brain Kinetics and Amyloid-Beta Pathology. [PDF]

ACS Pharmacol Transl Sci
Bispecific antibodies utilizing the transferrin receptor (TfR) for transport into the brain are being developed for both therapeutic and diagnostic targeting of the amyloid-β (Aβ) protein that deposits in the Alzheimer’s disease (AD) brain.
Schlein E, Lopes van den Broek S, Dallas T, Andersson KG, Syvänen S, Eriksson J, Sehlin D.   +6 more
europepmc   +2 more sources

Immuno-PET of epithelial ovarian cancer: Harnessing the potential of CA125 for non-invasive imaging [PDF]

, 2014
BACKGROUND: Epithelial ovarian cancer (EOC) is characterized by the overexpression of cancer antigen 125 (CA125), a mucinous glycoprotein that serves as a tumor biomarker.
Andrais, Bonnie, Glubrecht, Darryl, Lapi, Suzanne E, Sharma, Sai Kiran, Wang, Monica, Wuest, Frank, Wuest, Melinda   +6 more
core   +2 more sources

A Novel Theranostic Strategy for Malignant Pulmonary Nodules by Targeted CECAM6 with 89Zr/131I‐Labeled Tinurilimab

Advanced Science, Volume 12, Issue 21, June 5, 2025.
This study investigates the integrated diagnostic and therapeutic strategy utilizing 89Zr/131I‐labeled tinurilimab for the management of malignant lung nodules, with a particular focus on lung adenocarcinoma (LUAD). CEACAM6, which is highly expressed in most LUAD patients, activates the Src/FAK signaling pathway, thereby promoting cell proliferation ...
Chongyang Chen, Keying Zhu, Jing Wang, Donghui Pan, Xinyu Wang, Yuping Xu, Junjie Yan, Lizhen Wang, Min Yang   +8 more
wiley   +1 more source

Antibody Fragment and Affibody ImmunoPET Imaging Agents: Radiolabelling Strategies and Applications [PDF]

ChemMedChem, 2018
AbstractAntibodies have long been recognised as potent vectors for carrying diagnostic medical radionuclides, contrast agents and optical probes to diseased tissue for imaging. The area of ImmunoPET combines the use of positron emission tomography (PET) imaging with antibodies to improve the diagnosis, staging and monitoring of diseases.
Ruisi Fu, Laurence Carroll, Gokhan Yahioglu, Eric O. Aboagye, Philip W. Miller   +4 more
openaire   +4 more sources