Results 91 to 100 of about 2,997 (217)

Targeting CD70 in cancer: Mechanisms of immune escape and translational opportunities

Clinical and Translational Discovery, Volume 5, Issue 6, December 2025.
Hypoxia, oncogenic signaling (e.g., MAPK, STAT3), and histone modifications promote CD70 overexpression in cancer cells. Viral infections like EBV and HTLV‐1 induce CD70 expression in tumor and transformed immune cells. Tyrosine kinase inhibitors and chemotherapeutic agents induce CD70 expression through therapy‐related stress in cancer cells ...
Akash Sabarwal, Saba Tabasum, Laxminarayan Rawat, Soumitro Pal   +3 more
wiley   +1 more source

Imaging diagnosis and efficacy monitoring by [89Zr]Zr-DFO-KN035 immunoPET in patients with PD-L1-positive solid malignancies

Theranostics
Rationale: Although programmed death-ligand 1 (PD-L1) inhibitors have achieved efficacy in cancer therapy, their response rate is low. Differences in the prognosis of patients with cancer under anti-PD-L1 treatment are related to the PD-L1 level in ...
Huihui He, Xiaowei Qi, Haitian Fu, Jianfeng Xu, Qihuang Zheng, Liping Chen, Yu Zhang, Haiying Hua, Wenhua Xu, Zhenyu Xu, Xiaoping Chen, Qingjun You, Jianguo Lin, Gang Huang, Yong Mao, Chunjing Yu   +15 more
semanticscholar   +1 more source

ImmunoPET Imaging of TIM‐3 in Murine Melanoma Models

Advanced Therapeutics, 2020
AbstractT cell immunoglobulin and mucin domain‐containing‐3 (TIM‐3) is an immune checkpoint expressed mainly on CD4+ and CD8+ T cells. In addition to negatively regulating inflammatory T cell function, TIM‐3 is a promising immunotherapy target. Herein, the aim is to develop an immuno‐positron emission tomography (immunoPET) probe for noninvasively ...
Weijun Wei, Dawei Jiang, Hye Jin Lee, Jonathan W. Engle, Hisaya Akiba, Jianjun Liu, Weibo Cai   +6 more
openaire   +3 more sources

Tumor Cell Plasticity in Cancer: Signaling Pathways and Pharmaceutical Interventions

MedComm, Volume 6, Issue 12, December 2025.
Cell plasticity refers to a dynamic program through which cells reprogram their phenotype, acquiring new histologic and molecular characteristics. Recognized as a hallmark of cancer, cellular plasticity plays a critical role in tumor evolution.
Shangwei Sun, Yunwei Sun, Ling Lan, Siyuan Luan, Jin Zhou, Jiehui Deng, Yong Yuan, Zhong Wu   +7 more
wiley   +1 more source

CD146‐targeted nuclear medicine imaging in cancer: State of the art

View, 2023
The transmembrane glycoprotein adhesion molecule CD146 is overexpressed in a wide variety of cancers. CD146 expression constitutes a marker of poor prognosis and correlates with cancer progression.
Qi Yang, Wenpeng Huang, Jessica C. Hsu, Lele Song, Xinyao Sun, Cuicui Li, Weibo Cai, Lei Kang   +7 more
doaj   +1 more source

A genome-wide CRISPR screen identifies a restricted set of HIV host dependency factors [PDF]

, 2017
Host proteins are essential for HIV entry and replication and can be important nonviral therapeutic targets. Large-scale RNA interference (RNAi)-based screens have identified nearly a thousand candidate host factors, but there is little agreement among ...
A Clément, A Sigal, A Srivastava, AL Brass, Alexander Marson, Alicja Piechocka-Trocha, BF Keele, BJ Connell, Blandine Monel, BM Friedrich, Bruce D Walker, C Ochsenbauer, C Seibert, C Seibert, CA Sabatos, David M Sabatini, DD Shao, DG Gibson, DM Rosmarin, DW Williams, Dylan Koundakjian, E Ingulli, Eric S Lander, ES Egan, F Kajumo, G Doitsh, G Fätkenheuer, G Hütter, G Lin, GA Sowd, GW Swart, H Singh, H Yusuf-Makagiansar, H Zhou, Haiyan Yu, J Te Riet, J Zhu, Judd F Hultquist, K Inaba, K Schumann, K Weber, Kathrin Schumann, Kevin M Krupzcak, KL McKinley, L Wu, LC van Kempen, LM Agosto, M Cavrois, M Farzan, M Hommel, M Hourmant, M Iolyeva, M Rolando, M Sourisseau, MA Bowen, MA Brockman, MC Bassik, ML Dustin, MM Lai, MR Gardner, N Sasaki, NA Zumwalde, Nevan J Krogan, Nir Hacohen, O Shalem, P Chen, P Tebas, PA Baeuerle, Pedro Lamothe-Molina, PJ Santangelo, PK Singh, R Beisswanger, R Eri, R König, R Lorenzo-Redondo, RM Gulick, Ryan J Park, S Ghosh, S Jäger, S Kamiyama, T Hart, T Wang, T Wang, T Wang, Tim Wang, W Salzberger, WG Glass, WG Kaelin Jr., Wilfredo Garcia-Beltran, Y Desfosses, ZJ Gartner, ZM Ding   +91 more
core   +1 more source

PET/NIR‐II fluorescence imaging and image‐guided surgery of breast cancer using a CD47‐specific nanobody

VIEW, Volume 6, Issue 6, December 2025.
A CD47‐targeted dual‐modal imaging probe combining positron emission tomography and second near‐infrared fluorescence enables precise preoperative tumor localization and intraoperative guidance for complete resection of breast cancer lesions, including metastases, offering a promising strategy to enhance surgical accuracy and improve clinical outcomes.
Jun Li, Runge Zhao, Jinyuan Zhang, Zixuan Huang, Xiaoyan Wang, Rui Zhang, Chenghui Zheng, Mengjie Dong, Yongsheng Zhao, Jing Mu   +9 more
wiley   +1 more source

The Development and Challenges of PET/MRI Dual‐Modality Imaging Probes—An Update

Journal of Magnetic Resonance Imaging, Volume 62, Issue 5, Page 1245-1259, November 2025.
ABSTRACT The integration of Positron emission tomography (PET) with Magnetic resonance imaging (MRI) combines the functional imaging capabilities of PET with the high‐resolution anatomical detail of MRI, creating a synergistic platform for advanced diagnostic imaging and image‐guided therapies. Central to the success of this dual‐modality system is the
Maryam Sabbaghan, Saumya Nigam, Isabella Kasabasic, Medha Manepalli, Ping Wang, Jinda Fan   +5 more
wiley   +1 more source

CD146‐Targeted Multimodal Image‐Guided Photoimmunotherapy of Melanoma

Advanced Science, 2019
For melanoma resistant to molecularly targeted therapy and immunotherapy, new treatment strategies are urgently needed. A molecularly targeted theranostic pair may thus be of importance, where the diagnostic probe facilitates patient stratification and ...
Weijun Wei, Dawei Jiang, Emily B. Ehlerding, Todd E. Barnhart, Yunan Yang, Jonathan W. Engle, Quan‐Yong Luo, Peng Huang, Weibo Cai   +8 more
doaj   +1 more source

Imaging the L-type amino acid transporter-1 (LAT1) with Zr-89 immunoPET. [PDF]

PLoS ONE, 2013
The L-type amino acid transporter-1 (LAT1, SLC7A5) is upregulated in a wide range of human cancers, positively correlated with the biological aggressiveness of tumors, and a promising target for both imaging and therapy.
Oluwatayo F Ikotun, Bernadette V Marquez, Chaofeng Huang, Kazue Masuko, Miyamoto Daiji, Takashi Masuko, Jonathan McConathy, Suzanne E Lapi   +7 more
doaj   +1 more source