Results 71 to 80 of about 2,997 (217)

Bioorthogonal Fluorogenic Reporters for Noninvasive Imaging and Urinalysis of Immunotherapeutic Response in Renal Cell Carcinoma

open access: yesAdvanced Science, EarlyView.
This study reported renal‐clearable bio‐orthogonal near‐infrared fluorogenic probes (BGRs) that specifically imaging and urinalysis of granzyme B for dynamic evaluation of RCC immunotherapy. BGRs not only differentiate immunotherapeutic responses in orthotopic RCC mice, but also enable sensitive optical urinalysis of granzyme B in clinical specimens ...
Xingyue Yang   +9 more
wiley   +1 more source

Development of [89Zr]Zr-hCD103.Fab01A and [68Ga]Ga-hCD103.Fab01A for PET imaging to noninvasively assess cancer reactive T cell infiltration: Fab-based CD103 immunoPET

open access: yesEJNMMI Research, 2023
Background CD103 is an integrin specifically expressed on the surface of cancer-reactive T cells. The number of CD103+ T cells significantly increases during successful immunotherapy and might therefore be an attractive biomarker for noninvasive PET ...
Xiaoyu Fan   +10 more
doaj   +1 more source

Development of the designed ankyrin repeat protein (DARPin) G3 for HER2 molecular imaging [PDF]

open access: yes, 2014
s funded by the Seventh Framework Programme (FP7) for HER Imaging and Molecular Interaction Mapping in Breast Cancer (Imagint EC grant 259881) and the Breast Cancer Campaign.
Bhavsar, G   +14 more
core   +3 more sources

PET and optical imaging of caveolin-1 in gastric tumors [PDF]

open access: yes, 2023
Previous studies have suggested tumoral caveolin-1 (CAV1) as a predictive biomarker for the response to anti-HER2 antibody drug therapies in gastric tumors.
Lewis, Jason S   +3 more
core   +2 more sources

Harnessing ferroptosis from multilayer defense networks to nanoplatforms for specific cancer therapy

open access: yesBMEMat, EarlyView.
Nanomaterials target metabolically‐regulated ferroptosis for cancer therapy. Iron‐based or alternative nanoplatforms integrate ferroptosis with chemotherapy, immunotherapy, or radiotherapy. They enable stimulus‐responsive therapies (photothermal, photodynamic, sonodynamic) activated by near‐infrared, light, or ultrasound, achieving potent synergistic ...
Xinyue Xu   +5 more
wiley   +1 more source

Molecular Imaging of Chimeric Antigen Receptor T Cells by ICOS-ImmunoPET [PDF]

open access: yesClinical Cancer Research, 2020
Abstract Purpose: Immunomonitoring of chimeric antigen receptor (CAR) T cells relies primarily on their quantification in the peripheral blood, which inadequately quantifies their biodistribution and activation status in the tissues.
Federico Simonetta   +22 more
openaire   +2 more sources

Bevacizumab radioimmunotherapy (RIT) with accelerated blood clearance using the avidin chase [PDF]

open access: yes, 2018
学位記番号 ...
RYAN, YUDISTIRO   +1 more
core  

Pretargeting of internalizing trastuzumab and cetuximab with a 18F-tetrazine tracer in xenograft models [PDF]

open access: yes, 2017
Pretargeting-based approaches are being investigated for radioimmunoimaging and therapy applications to reduce the effective radiation burden to the patient.
Airaksinen, Anu   +9 more
core   +2 more sources

Proteolysis at the extracellular matrix interface: Molecular architects and regulators in health and disease

open access: yesThe FEBS Journal, EarlyView.
The extracellular matrix (ECM) is a dynamic scaffold that orchestrates tissue architecture and cellular communication. A critical but underexplored interplay between proteases and cluster of differentiation molecules (CD) governs ECM turnover and directs cell fate.
David Jurnečka   +3 more
wiley   +1 more source

Targeting MT1-MMP as an ImmunoPET-Based Strategy for Imaging Gliomas. [PDF]

open access: yesPLoS ONE, 2016
A critical challenge in the management of Glioblastoma Multiforme (GBM) tumors is the accurate diagnosis and assessment of tumor progression in a noninvasive manner.
A G de Lucas   +10 more
doaj   +1 more source

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