Results 21 to 30 of about 2,997 (217)

B-cell maturation antigen targeted PET/CT imaging in multiple myeloma: a first-in-human study [PDF]

Journal of Hematology & Oncology
B-cell maturation antigen (BCMA)-targeted positron emission tomography/computed tomography (PET/CT) represents a promising tool for the management of multiple myeloma, enabling noninvasive and quantitative evaluation across different disease stages. This
Tingfei Gu, Zhao Chen, Tianyao Wang, Yujun Dong, Lei Kang   +4 more
doaj   +2 more sources

ImmunoPET imaging of TIGIT in the glioma microenvironment

Scientific Reports
Glioblastoma (GBM) is the most common primary malignant brain tumor. Currently, there are few effective treatment options for GBM beyond surgery and chemo-radiation, and even with these interventions, median patient survival remains poor.
Sarah R. Vincze, Ambika P. Jaswal, Stephen C. Frederico, Michal Nisnboym, Bo Li, Zujian Xiong, ReidAnn E. Sever, Chaim T. Sneiderman, Mikayla Rodgers, Kathryn E. Day, Joseph D. Latoche, Lesley M. Foley, T. Kevin Hitchens, Robin Frederick, Ravi B. Patel, Costas G. Hadjipanayis, Itay Raphael, Jessie R. Nedrow, W. Barry Edwards, Gary Kohanbash   +19 more
doaj   +3 more sources

High-affinity transferrin receptor binding improves brain delivery of bispecific antibodies at tracer dose [PDF]

Fluids and Barriers of the CNS
Background Transferrin receptor (TfR)-mediated transcytosis is a well-established method for delivering biologic therapeutics and diagnostics to the brain.
Gillian Bonvicini, Sunitha Singh, Lisa Sandersjöö, Tiffany Dallas, Eva Schlein, Amelia D. Dahlén, Sara Lopes van den Broek, Dag Sehlin, Ken G. Andersson, Stina Syvänen   +9 more
doaj   +2 more sources

ImmunoPET Directed to the Brain: A New Tool for Preclinical and Clinical Neuroscience

Biomolecules, 2023
Immuno-positron emission tomography (immunoPET) is a non-invasive in vivo imaging method based on tracking and quantifying radiolabeled monoclonal antibodies (mAbs) and other related molecules, such as antibody fragments, nanobodies, or affibodies ...
Ángel García de Lucas, Urpo Lamminmäki, Francisco R. López-Picón   +2 more
doaj   +1 more source

Editorial: ImmunoPET imaging in disease diagnosis and therapy assessment

Frontiers in Medicine, 2023
Francisca Mulero
doaj   +4 more sources

Improved image reconstruction of 89Zr-immunoPET studies using a Bayesian penalized likelihood reconstruction algorithm

EJNMMI Physics, 2021
Purpose The aim of this study was to evaluate the use of a Bayesian penalized likelihood reconstruction algorithm (Q.Clear) for 89Zr-immunoPET image reconstruction and its potential to improve image quality and reduce the administered activity of 89Zr ...
Julian Kirchner, Joseph A. O’Donoghue, Anton S. Becker, Gary A. Ulaner   +3 more
doaj   +1 more source

Colitis ImmunoPET [PDF]

Inflammatory Bowel Diseases, 2016
Positron emission tomography combined with a specific probe presents the ability to noninvasively assess inflammatory bowel disease. We previously reported increased intestinal uptake of a Cu-labeled anti-β7 integrin antibody (clone FIB504.64) in colitic mice.
Jason L J, Dearling, Ala, Daka, Nuphar, Veiga, Dan, Peer, Alan B, Packard   +4 more
openaire   +2 more sources

Radiochemistry, Production Processes, Labeling Methods, and ImmunoPET Imaging Pharmaceuticals of Iodine-124

Molecules, 2021
Target-specific biomolecules, monoclonal antibodies (mAb), proteins, and protein fragments are known to have high specificity and affinity for receptors associated with tumors and other pathological conditions.
Krishan Kumar, Arijit Ghosh
doaj   +1 more source

Monitoring Response to Combinatorial Immunotherapies by Tracking both T Cells and Natural Killer Cells <i>In Vivo</i> via ImmunoPET-Raman Multimodal Gold Nanostars. [PDF]

ACS Appl Mater Interfaces
Real-time imaging of multiple immunomarkers in vivo is crucial to predict treatment response and to understand the complex interplay of immune cells such as CD8+ T cells and natural killer (NK) cells in the tumor microenvironment (TME).
Cutshaw GP, Kothadiya S, Uthaman S, Pandya DN, Wen X, Mathew A, Sinha A, Antony I, Vilgelm AE, Wadas TJ, Mitchell JS, Bardhan R.   +11 more
europepmc   +2 more sources

Imaging PD-L1 Expression with ImmunoPET [PDF]

Bioconjugate Chemistry, 2017
High sensitivity imaging tools could provide a more holistic view of target antigen expression to improve the identification of patients who might benefit from cancer immunotherapy. We developed for immunoPET a novel recombinant human IgG1 (termed C4) that potently binds an extracellular epitope on human and mouse PD-L1 and radiolabeled the antibody ...
Charles Truillet, Hsueh Ling J. Oh, Siok Ping Yeo, Chia-Yin Lee, Loc T. Huynh, Junnian Wei, Matthew F. L. Parker, Collin Blakely, Natalia Sevillano, Yung-Hua Wang, Yuqin S. Shen, Victor Olivas, Khaled M. Jami, Anna Moroz, Benoit Jego, Emilie Jaumain, Lawrence Fong, Charles S. Craik, Albert J. Chang, Trever G. Bivona, Cheng-I Wang, Michael J. Evans   +21 more
openaire   +4 more sources