Results 41 to 50 of about 2,997 (217)

A Reflection on the Evolution of Antibody-Based Therapies in Oncology: Trastuzumab as an Exemplar-Commentary on Dijkers et al. [PDF]

Clin Pharmacol Ther
Clinical Pharmacology &Therapeutics, Volume 117, Issue 6, Page 1577-1587, June 2025.
Holstein SA.
europepmc   +2 more sources

Towards Translational ImmunoPET/MR Imaging of Invasive Pulmonary Aspergillosis: The Humanised Monoclonal Antibody JF5 Detects Aspergillus Lung Infections In Vivo [PDF]

, 2017
This is the final published versionAvailable from Ivyspring International Publisher via the DOI in this recordInvasive pulmonary aspergillosis (IPA) is a life-threatening lung disease of hematological malignancy and bone marrow transplant patients caused
Boschetti, F, Davies, G, Denat, F, Dubois, A, Eichner, M, Foslet, J, Gunzer, M, Hasenberg, M, Jensen, M, Maurer, A, Pichler, BJ, Rolle, A-M, Ryder, LS, Schibli, R, Schillinger, C, Solouk-Saran, D, Spycher, PR, Thornton, CR, Weski, J, Wiehr, S   +19 more
core   +3 more sources

Development and comparison of 68Ga/18F/64Cu-labeled nanobody tracers probing Claudin18.2

Molecular Therapy: Oncolytics, 2022
Claudin 18.2 (CLDN18.2) is an emerging target for the treatment of gastric cancers. We aim to develop tracers to image the expression of CLDN18.2. A humanized nanobody targeting CLDN18.2 (clone hu19V3) was produced and labeled with 68Ga, 64Cu, and 18F ...
Weijun Wei, Di Zhang, You Zhang, Lianghua Li, Yuchen Jin, Shuxian An, Chun lv, Haitao Zhao, Cheng Wang, Yanshan Huang, Jiali Dong, Gang Huang, Jianjun Liu   +12 more
doaj   +1 more source

Positron emission tomography imaging of endometrial cancer using engineered anti-EMP2 antibody fragments. [PDF]

, 2012
PurposeAs imaging of the cell surface tetraspan protein epithelial membrane protein-2 (EMP2) expression in malignant tumors may provide important prognostic and predictive diagnostic information, the goal of this study is to determine if antibody ...
Braun, Jonathan, Brewer, Sarah, Fu, Maoyong, Gordon, Lynn K, Olafsen, Tove, Said, Jonathan, Wadehra, Madhuri, Wu, Anna M   +7 more
core   +3 more sources

Measuring the pharmacodynamic effects of a novel Hsp90 inhibitor on HER2/neu expression in mice using Zr-DFO-trastuzumab. [PDF]

PLoS ONE, 2010
The positron-emitting radionuclide (89)Zr (t(1/2) = 3.17 days) was used to prepare (89)Zr-radiolabeled trastuzumab for use as a radiotracer for characterizing HER2/neu-positive breast tumors.
Jason P Holland, Eloisi Caldas-Lopes, Vadim Divilov, Valerie A Longo, Tony Taldone, Danuta Zatorska, Gabriela Chiosis, Jason S Lewis   +7 more
doaj   +1 more source

ImmunoPET Imaging of Multiple Myeloma with [68Ga]Ga-NOTA-Nb1053 [PDF]

European Journal of Nuclear Medicine and Molecular Imaging, 2021
Abstract Purpose Multiple myeloma (MM) remains incurable and its diagnosis relies heavily on bone marrow aspiration and biopsy. CD38 is a glycoprotein highly specific for MM. Antibody therapeutics (e.g., daratumumab) targeting CD38 have shown encouraging efficacy in treating MM, either as a monotherapy agent or in combination with other ...
Cheng Wang, Yumei Chen, Yun Nan Hou, Qiufang Liu, Di Zhang, Haitao Zhao, You Zhang, Shuxian An, Lianghua Li, Jian Hou, Gang Huang, Jianjun Liu, Yong Juan Zhao, Weijun Wei   +13 more
openaire   +3 more sources

Rapid and specific immunoPET imaging of Nectin-4 in gastric cancer and non-small cell lung cancer using [⁶⁴Cu]Cu-NOTA-EV-F(ab')₂. [PDF]

Eur J Nucl Med Mol Imaging
This study aimed to develop and evaluate [64Cu]Cu-NOTA-EV-F(ab’)2 as a rapid and specific immunoPET imaging probe targeting Nectin-4 in gastric cancer (GC) and non-small cell lung cancer (NSCLC).
Huang W, Sun X, Li X, Hsu JC, Qiu Y, DeLuca MC, Engle JW, Li L, Lu J, Wang T, Kang L, Cai W.   +11 more
europepmc   +2 more sources

The molecular imaging suite: applications in nanotechnology, targeted imaging and cell tracking [PDF]

, 2012
The blurring of the boundaries between the disciplines of engineering and the biological sciences has revolutionized medicine. Medicine is still a science of decisionmaking under uncertainty.
Ruggiero, A. (Alessandro)
core   +8 more sources

Positive Progress in ImmunoPET—Not Just a Coincidence [PDF]

Cancer Biotherapy and Radiopharmaceuticals, 2010
The identification of tumor tissue biomarkers has led to the production, validation, and Food and Drug Administration-approval of a number of antibody-based targeted therapeutics in the past two decades. As a result of the significant role that these immunotherapeutics play in the management of cancer, and the potential utility of complementary imaging
Katelyn E, McCabe, Anna M, Wu
openaire   +2 more sources

Immuno-PET: Design options and clinical proof-of-concept

Frontiers in Medicine, 2022
Radioimmunoconjugates have been used for over 30 years in nuclear medicine applications. In the last few years, advances in cancer biology knowledge have led to the identification of new molecular targets specific to certain patient subgroups. The use of
Alexandre Lugat, Clément Bailly, Clément Bailly, Michel Chérel, Michel Chérel, Caroline Rousseau, Caroline Rousseau, Françoise Kraeber-Bodéré, Françoise Kraeber-Bodéré, Caroline Bodet-Milin, Caroline Bodet-Milin, Mickaël Bourgeois, Mickaël Bourgeois, Mickaël Bourgeois   +13 more
doaj   +1 more source