Results 31 to 40 of about 2,997 (217)

ImmunoPET Targeting Receptor Tyrosine Kinase: Clinical Applications

Cancers, 2023
Receptor tyrosine kinases, or RTKs, are one large family of cell surface receptors involved in signal transduction, which represent an integral part of the signaling pathways. They play a crucial role in most important cellular processes, starting with the cell cycle, proliferation and differentiation, as well as cell migration, metabolism and survival.
Flavia Linguanti, Elisabetta Maria Abenavoli, Raffaella Calabretta, Valentina Berti, Egesta Lopci   +4 more
openaire   +3 more sources

ImmunoPET imaging of amyloid-beta in a rat model of Alzheimer’s disease with a bispecific, brain-penetrating fusion protein

Translational Neurodegeneration, 2022
Background Hijacking the transferrin receptor (TfR) is an effective strategy to transport amyloid-beta (Aβ) immuno-positron emission tomography (immunoPET) ligands across the blood–brain barrier (BBB).
Gillian Bonvicini, Stina Syvänen, Ken G. Andersson, Merja Haaparanta-Solin, Francisco López-Picón, Dag Sehlin   +5 more
doaj   +1 more source

Local and distant response to intratumoral immunotherapy assessed by immunoPET in mice

Journal for ImmunoTherapy of Cancer, 2023
Background Despite the promising efficacy of immune checkpoint blockers (ICB), tumor resistance and immune-related adverse events hinder their success in cancer treatment.
Aurélien Marabelle, Louis Meyblum, Lambros Tselikas, Thierry de Baere, Sandrine Susini, Fréderic Deschamps, Baptiste Bonnet, Céline Chevaleyre, Benoit Jego, Dimitri Kereselidze, Vincent Lebon, Charles Truillet   +11 more
doaj   +1 more source

ImmunoPET imaging of Trop2 expression in triple-negative breast cancer using [⁶⁴Cu]Cu-NOTA-Trodelvy-F(ab')₂. [PDF]

Eur J Nucl Med Mol Imaging
Huang W, Zhang Y, Xiao X, Yang Q, Mixdorf JC, Sun X, Engle JW, Fan Y, Li L, Kang L, Cai W.   +10 more
europepmc   +2 more sources

Clinical Application of ImmunoPET Targeting Checkpoint Inhibitors

Cancers, 2023
In the last decade, monoclonal antibodies (mAbs) targeting CTLA-4, PD-1, or PD-L1 have been developed and immune checkpoint inhibitors (ICIs) have become the main approach in cancer immunotherapy. However, not all patients benefit from ICI therapy and some are at risk of developing treatment-induced side-effects.
Elisabetta Maria Abenavoli, Flavia Linguanti, Raffaella Calabretta, Roberto C. Delgado Bolton, Valentina Berti, Egesta Lopci   +5 more
openaire   +3 more sources

Predicting CAR-T cell Immunotherapy Success through ImmunoPET

Clinical Cancer Research, 2021
Abstract Chimeric antigen receptor (CAR)-T cell therapy has generated unprecedented advances in the treatment of hematologic cancers, but readily translatable imaging approaches to visualize the in vivo dynamics of CAR-T cells are lacking. Noninvasive PET imaging is the ideal tool to monitor CAR-T cells.
Alessia Volpe, Veronica L. Nagle, Jason S. Lewis, Vladimir Ponomarev   +3 more
openaire   +3 more sources

Current Landscape and Emerging Fields of PET Imaging in Patients with Brain Tumors

Molecules, 2020
The number of positron-emission tomography (PET) tracers used to evaluate patients with brain tumors has increased substantially over the last years. For the management of patients with brain tumors, the most important indications are the delineation of ...
Jan-Michael Werner, Philipp Lohmann, Gereon R. Fink, Karl-Josef Langen, Norbert Galldiks   +4 more
doaj   +1 more source

Visualizing Galectin-3 Binding Protein Expression with ImmunoPET

Molecular Pharmaceutics, 2023
Galectin-3 binding protein (Gal-3BP) is a glycoprotein that is overexpressed and secreted by several cancers and has been implicated as a marker of both tumor progression and poor prognosis in melanoma, non-small cell lung cancer, head and neck squamous cell carcinoma, and breast cancer.
Keinänen, Outi, Sarrett, Samantha M, Delaney, Samantha, Rodriguez, Cindy, Dayts, Eric J, Capone, Emily, Sauniere, Frederic, Ippoliti, Rodolfo, Sala, Gianluca, Iacobelli, Stefano, Zeglis, Brian M   +10 more
openaire   +3 more sources

Imaging alloreactive T cells provides early warning of organ transplant rejection

JCI Insight, 2021
Diagnosis of organ transplant rejection relies upon biopsy approaches to confirm alloreactive T cell infiltration in the graft. Immune molecular monitoring is under investigation to screen for rejection, though these techniques have suffered from low ...
Toshihito Hirai, Aaron T. Mayer, Tomomi W. Nobashi, Po-Yu Lin, Zunyu Xiao, Tomokatsu Udagawa, Kinya Seo, Federico Simonetta, Jeanette Baker, Alan G. Cheng, Robert S. Negrin, Sanjiv S. Gambhir   +11 more
doaj   +1 more source

ImmunoPET Imaging of Trop2 Expression in Bladder Cancer Using [⁶⁴Cu]Cu-NOTA-Trodelvy. [PDF]

Mol Pharm
Trop2 exhibits significantly elevated expression in numerous solid malignancies, playing a crucial role in tumor advancement, whereas its presence in healthy tissues is minimal.
Huang W, Wang T, Chao F, Yang Q, Mixdorf JC, Li L, Engle JW, Fan Y, Kang L, Cai W.   +9 more
europepmc   +2 more sources