Results 91 to 100 of about 3,957 (191)

Guiding the Application of Immunotherapy in Nonsmall Cell Lung Cancer: The Role of Biomarkers

Thoracic Cancer, Volume 17, Issue 18, September 2026.
The content is divided into three main parts: (1) Predictive biomarkers: this includes six detailed subcategories. (2) Prediction of immune resistance: Lists relevant cell and gene markers. (3) Prediction of immune‐related adverse reactions. ABSTRACT Although immunotherapy has completely transformed the treatment landscape of nonsmall cell lung cancer (
Yuting Sun, Xuelei Chu, Xinmiao Wang, Weina Li, Xiaoyu Zhu, Guanghui Zhu, Xinyi Ma, Xue He, Jie Li   +8 more
wiley   +1 more source

The Immunoscore in the Clinical Practice of Patients with Colon and Rectal Cancers

Chirurgia, 2019
In the fine balance between tumor invasion and our defensive systems, the role played by the adaptive immune response at the tumor site is critical. Beyond the fact that all the immune components of the innate and adaptive response can be observed to varying degrees in the tumor microenvironment, it appears that a high density of T cytotoxic and memory
Guy, Zeitoun, Carine El, Sissy, Amos, Kirilovsky, Gabriela, Anitei, Anna-Maria, Todosi, Florence, Marliot, Nacilla, Haicheur, Christine, Lagorce, Anne, Berger, Franck, Zinzindohoué, Jérome, Galon, Viorel, Scripcariu, Franck, Pagès   +12 more
openaire   +2 more sources

Closing the Translational Gap: Closed‐Loop AI Discovery Frameworks for Experimental Validation and Clinical Implementation in Cancer Therapeutics

Cancer Medicine, Volume 15, Issue 8, August 2026.
Artificial intelligence accelerates cancer therapeutic development through an iterative, closed‐loop pipeline: from AI‐driven target and drug discovery, through automated synthesis and screening, to experimental validation in in vivo tumor models, culminating in clinical translation guided by patient data.
Tuğba Ören Varol, Mehmet Varol
wiley   +1 more source

An integrated classifier improves prognostic accuracy in non-metastatic gastric cancer

OncoImmunology, 2020
The American Joint Committee on Cancer (AJCC) staging system is insufficiently prognostic for gastric cancer (GC) patients and complementary factors are in urgent need.
Xiaofang Xing, Shuqin Jia, Yuxin Leng, Qian Wang, Zhongwu Li, Bin Dong, Ting Guo, Xiaojing Cheng, Hong Du, Ying Hu, Qin Feng, Shenyi Lian, Fengming Luan, Xiaoxiao Ma, Zhe Li, Ming Ni, Ziyu Li, Jiafu Ji   +17 more
doaj   +1 more source

Immune Cell Composition in Human Non-small Cell Lung Cancer

Frontiers in Immunology, 2019
Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related death in the world. Immunological analysis of the tumor microenvironment (immunoscore) shows great promise for improved prognosis and prediction of response to immunotherapy ...
Branislava Stankovic, Heidi Anine Korsmo Bjørhovde, Renate Skarshaug, Henrik Aamodt, Henrik Aamodt, Astri Frafjord, Elisabeth Müller, Clara Hammarström, Kahsai Beraki, Espen S. Bækkevold, Per Reidar Woldbæk, Åslaug Helland, Åslaug Helland, Åslaug Helland, Odd Terje Brustugun, Inger Øynebråten, Alexandre Corthay   +16 more
doaj   +1 more source

Table_2_Clinical Significance of a CD3/CD8-Based Immunoscore in Neuroblastoma Patients Using Digital Pathology.xlsx

, 2022
BackgroundInfiltrating immune cells have been reported as prognostic markers in many cancer types. We aimed to evaluate the prognostic role of tumor-infiltrating lymphocytes, namely CD3+ T cells, CD8+ cytotoxic T cells and memory T cells (CD45RO+), in ...
Liang-Jun Qin (12523744), Shuo-Yu Xu (7863191), Ran Wang (169166), Le Li (356426), Lei Miao (528184), Sha Fu (445944), Feng-Hua Wang (1762480), Xiao-Yun Liu (11899710), Shu-Hua Li (691392), Fang Wang (105926), Na Liu (102929), Liang Zeng (791005), Hai-Yun Wang (223336), Kai Chen (129938), Ling Deng (713393)   +14 more
core   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, Volume 20, Issue 6, Page 1535-1555, June 2026.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Multicenter International Society for Immunotherapy of Cancer Study of the Consensus Immunoscore for the Prediction of Survival and Response to Chemotherapy in Stage III Colon Cancer. [PDF]

, 2020
PURPOSE The purpose of this study was to evaluate the prognostic value of Immunoscore in patients with stage III colon cancer (CC) and to analyze its association with the effect of chemotherapy on time to recurrence (TTR).
Léonard, Daniel, Paustian, Christopher, MacGregor, Heather L, Muşină, Ana-Maria, Dijkstra, Jeroen, Zavadova, Eva, Rau, Tilman T., El Sissy, Carine, Merkel, Susanne, Han, SeongJun, Galon, Jérôme, Kirilovsky, Amos, Popivanova, Boryana, Kolwelter, Julie, Wang, Julia Y, Vora, Hemangini H, Hafezi-Bakhtiari, Sara, Vink-Börger, Elisa, Ballesteros-Merino, Carmen, Maio, Michele, Patel, Prabhu S, Berger, Martin D., Marincola, Francesco M, Mourin, Anne, Hartmann, Arndt, Knijn, Nikki, Patel, Jayendrakumar B, Marliot, Florence, Scripcariu, Dragos-Viorel, Xu, Mingli, Grizzi, Fabio, Masucci, Giuseppe V, Nagano, Hiroaki, Bindea, Gabriela, Delrio, Paolo, Hazama, Shoichi, Nagtegaal, Iris D, Skalova, Helena, Botti, Gerardo, Roehrl, Michael H A, Okuno, Kiyotaka, Haicheur, Nacilla, Sato, Noriyuki, Rau, Tilman T, Lanzi, Anastasia, Bifulco, Carlo, Kartheuser, Alex, Kawakami, Yutaka, Bavi, Prashant, Nguyen, Linh T, Nemejcova, Kristyna, Lagorce, Christine, Ascierto, Paolo A, Furuhata, Tomohisa, Pagès, Franck, Pandya, Shashank J, Andersson, Emilia K, Fox, Bernard A, Fredriksen, Tessa, Jouret-Mourin, Anne, Ciliberto, Gennaro, Wang, Yili, Buttard, Bénédicte, Lugli, Alessandro, Torigoe, Toshihiko, Geppert, Carol, Tatangelo, Fabiana, Laghi, Luigi, van Lent-van Vliet, Shannon, van de Water, Carlijn, Itoh, Kyogo, Mlecnik, Bernhard, Rajvik, Kruti N, Zhang, Guanjun, Shah, Birva, Remue, Christophe, Zlobec, Inti, Dundr, Pavel, Berger, Anne, Petruzelka, Lubos, Berger, Martin D, Wouters, Bradly G, Spacek, Jan, Suzuki, Nobuaki, Shukla, Shilin N, Vocka, Michal, Lafontaine, Lucie, Lee, J Jack, Grützmann, Robert, Fujita, Tomonobu, Konopasek, Bohuslav, Takemasa, Ichiro, Van den Eynde, Marc, Ohashi, Pamela S, Bruni, Daniela   +94 more
core   +1 more source

Immunoscore Signature Predicts Postoperative Survival and Adjuvant Chemotherapeutic Benefits in Esophageal Squamous Cell Carcinoma

Cancer Management and Research, 2020
Lingdun Zhuge,1,2,* Binhao Huang,1,2,* Juntao Xie,1,2 Zhendong Gao,1,2 Difan Zheng,1,2 Shanbo Zheng,1,2 Jiaqing Xiang,1,2 Jie Zhang3 1Department of Thoracic Surgery, Fudan University Shanghai Cancer Center, Shanghai, People’s Republic of China ...
Zhuge L, Huang B, Xie J, Gao Z, Zheng D, Zheng S, Xiang J, Zhang J   +7 more
doaj  

Quantifying Immunoscore performance [PDF]

The Lancet, 2018
Ryan, Sun, Lei, Nie, Bo, Huang, Dae Hyun, Kim, Lee-Jen, Wei   +4 more
openaire   +2 more sources