Results 81 to 90 of about 3,957 (191)

Artificial Intelligence in Gastric Cancer: Diagnostic, Prognostic, and Predictive Developments, Evidence Maturity, and Translational Challenges

Cancer Reports, Volume 9, Issue 10, October 2026.
ABSTRACT Background Gastric cancer (GC) remains a major global health burden characterized by substantial heterogeneity in diagnosis, prognosis, and treatment response. Artificial intelligence (AI), including machine learning (ML) and deep learning (DL), has been increasingly investigated for the analysis of endoscopic images, radiological scans, whole‐
Chong Chen, Weisong Xu, Tong Wu, Junpeng Zhao, Xuebing Xu, Mingbing Xiao, Kang Xu   +6 more
wiley   +1 more source

Multiverse of immune microenvironment in metastatic colorectal cancer

OncoImmunology, 2020
The comprehensive analysis of patients with a complete resection of all metastases reveals the heterogeneity of the colorectal metastatic disease and its clinical impact.
Marc Van den Eynde, Bernhard Mlecnik, Gabriela Bindea, Jérôme Galon   +3 more
doaj   +1 more source

License to kill: microsatellite instability and immune contexture

OncoImmunology, 2021
Colorectal cancers (CRCs) with microsatellite instability (MSI) are due to a defect in the DNA mismatch repair (MMR) system resulting in an accumulation of frame-shift mutations.
Pauline Maby, Gabriela Bindea, Bernhard Mlecnik, Jérôme Galon   +3 more
doaj   +1 more source

Tumor Infiltrating Lymphocyte Therapy Combined With PD‐1/LAG‐3 Inhibition in Patients With Recurrent Platinum‐Resistant Ovarian Cancer

International Journal of Cancer, Volume 159, Issue 7, Page 1735-1749, 1 October 2026.
The detection of tumor‐infiltrating lymphocytes (TILs) is a positive prognostic factor in ovarian cancer. Moreover, TILs are significantly boosted by immunotherapy, though ovarian cancer patients have seen limited benefit from immune therapies. This study investigated the safety and feasibility of TIL therapy combined with PD‐1 and LAG‐3 inhibitors in ...
Tine J. Monberg, Cathrine L. Lorentzen, Marie C. W. Westergaard, Trine Z. Iversen, Troels H. Borch, Marco Donia, Sigrid M. Mannering, Stine E. W. Banke, Özcan Met, Inge Marie Svane   +9 more
wiley   +1 more source

The prognostic effect of immunoscore in patients with clear cell renal cell carcinoma: preliminary results

, 2020
Purpose This study aimed to evaluate the density of CD8(+) and CD3(+) tumor-infiltrating lymphocytes (TILs) and determine whether the immunoscore has any prognostic effect on the oncological outcomes in patients with clear cell renal cell carcinoma (RCC).
Demirci, Umut, Selvi, İsmail, Bozdogan, Nazan, Basar, Halil   +3 more
core   +1 more source

Colorectal Cancer: Epidemiology, Risk Factors, Signaling Pathways, Clinical Features, Screening, Diagnosis, and Management

MedComm, Volume 7, Issue 10, October 2026.
Colorectal cancer is a heterogeneous, adaptive disease shaped by population‐level risk, genomic and epigenetic alterations, tumor ecosystem evolution, and treatment pressure. This review integrates epidemiology, risk factors, signaling networks, clinical presentation, screening, molecular diagnosis, and stage‐ and biomarker‐guided management while ...
Kairui Wan, Ke Tang, Linglong Wang, Qin Tian, Mingwei Zheng, Cheng Qian, Limei Liu   +6 more
wiley   +1 more source

Ineffectiveness of immune checkpoint inhibitors in prostate cancer: is it just a question of ‘‐mabs’?

The Journal of Pathology, Volume 270, Issue 2, Page 139-162, October 2026.
Abstract Prostate cancer (PCa) is the second most common type of neoplasm, currently treated with a variety of therapeutic agents. Although advances in treatment over the past decade have improved overall survival, patients with advanced PCa eventually progress from hormone‐sensitive PCa to metastatic castration‐resistant PCa.
Giuseppe Schepisi, Irene Torresan, Emilio Francesco Giunta, Sara Bleve, Nicole Brighi, Elisa Tassinari, Sofia Zanuccoli, Maria Concetta Cursano, Cristian Lolli   +8 more
wiley   +1 more source

Association of artificial intelligence-based immunoscore with the efficacy of chemoimmunotherapy in patients with advanced non-squamous non-small cell lung cancer: a multicentre retrospective study

Frontiers in Immunology
PurposeCurrently, chemoimmunotherapy is effective only in a subset of patients with advanced non-squamous non-small cell lung cancer. Robust biomarkers for predicting the efficacy of chemoimmunotherapy would be useful to identify patients who would ...
Jiaqing Liu, Jiaqing Liu, Jiaqing Liu, Jiaqing Liu, Dongchen Sun, Dongchen Sun, Dongchen Sun, Dongchen Sun, Shuoyu Xu, Jiayi Shen, Jiayi Shen, Jiayi Shen, Jiayi Shen, Wenjuan Ma, Wenjuan Ma, Wenjuan Ma, Wenjuan Ma, Huaqiang Zhou, Huaqiang Zhou, Huaqiang Zhou, Huaqiang Zhou, Yuxiang Ma, Yuxiang Ma, Yuxiang Ma, Yuxiang Ma, Yaxiong Zhang, Yaxiong Zhang, Yaxiong Zhang, Yaxiong Zhang, Wenfeng Fang, Wenfeng Fang, Wenfeng Fang, Wenfeng Fang, Yuanyuan Zhao, Yuanyuan Zhao, Yuanyuan Zhao, Yuanyuan Zhao, Shaodong Hong, Shaodong Hong, Shaodong Hong, Shaodong Hong, Jianhua Zhan, Jianhua Zhan, Jianhua Zhan, Jianhua Zhan, Xue Hou, Xue Hou, Xue Hou, Xue Hou, Hongyun Zhao, Hongyun Zhao, Hongyun Zhao, Hongyun Zhao, Yan Huang, Yan Huang, Yan Huang, Yan Huang, Bingdou He, Yunpeng Yang, Yunpeng Yang, Yunpeng Yang, Yunpeng Yang, Li Zhang, Li Zhang, Li Zhang, Li Zhang   +65 more
doaj   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, Volume 16, Issue 9, Page 1813-1824, September 2026.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

Tumor spread or siege immunity: dissemination to distant metastasis or not

OncoImmunology, 2021
Metastasis is the leading cause of cancer mortality. We have investigated the tumor microenvironment at all metastatic cascade steps (early-metastasic dissemination, synchronous metastasis, metachronous metastasis) to delineate the impact of tumor and ...
Gabriela Bindea, Bernhard Mlecnik, Jérôme Galon   +2 more
doaj   +1 more source