Results 71 to 80 of about 3,200 (166)

The Sepsis ImmunoScore Predicts Sepsis, Mortality, and Deterioration Better than Clinical Scores and Widely Available Biomarkers

Diagnostics
Background: Early and accurate risk stratification of patients suspected of serious infection is essential for improving outcomes, but existing diagnostic and predictive tools have limited accuracy.
Gregory L. Watson, Lincoln C. Updike, Carlos G. López-Espina, Akhil Bhargava, Lee A. Schmalz, Shah Khan, Dennys S. Urdiales, Matthew D. Sims, Ashok V. Palagiri, Adrian D. Haimovich, Alon Dagan, Benjamin P. Davis, Karen C. White, Paul A. Gurbel, Stockton M. Mayer, Anwaruddin Syed, Sihai Dave Zhao, Ruoqing Zhu, Rashid Bashir, Nathan I. Shapiro, Bobby Reddy   +20 more
doaj   +1 more source

Characterisation of tumor‐infiltrating gamma‐delta T cells in human colorectal cancer with MHC‐I loss

Clinical &Translational Immunology, Volume 15, Issue 5, 2026.
Abstract Objectives Gamma‐delta (γδ) T cells have been associated with favorable prognoses across several malignancies, underscoring their potential as targets for novel immunotherapies. These unconventional T lymphocytes exhibit an intrinsic tropism for the tumor microenvironment, largely driven by their capacity to recognize stress‐induced antigens ...
Tianming A Li, Luke T Quigley, Kok Fei Chan, David S Williams, Lisa A Mielke, Andreas Behren, Jessica Da Gama Duarte   +6 more
wiley   +1 more source

The Immunoscore in the Clinical Practice of Patients with Colon and Rectal Cancers

Chirurgia, 2019
In the fine balance between tumor invasion and our defensive systems, the role played by the adaptive immune response at the tumor site is critical. Beyond the fact that all the immune components of the innate and adaptive response can be observed to varying degrees in the tumor microenvironment, it appears that a high density of T cytotoxic and memory
Guy, Zeitoun, Carine El, Sissy, Amos, Kirilovsky, Gabriela, Anitei, Anna-Maria, Todosi, Florence, Marliot, Nacilla, Haicheur, Christine, Lagorce, Anne, Berger, Franck, Zinzindohoué, Jérome, Galon, Viorel, Scripcariu, Franck, Pagès   +12 more
openaire   +2 more sources

Tumor spread or siege immunity: dissemination to distant metastasis or not

OncoImmunology, 2021
Metastasis is the leading cause of cancer mortality. We have investigated the tumor microenvironment at all metastatic cascade steps (early-metastasic dissemination, synchronous metastasis, metachronous metastasis) to delineate the impact of tumor and ...
Gabriela Bindea, Bernhard Mlecnik, Jérôme Galon   +2 more
doaj   +1 more source

Neutrophil to Lymphocyte and Lymphocyte to Monocyte Ratios Predict Improved Survival and Response to Induction Chemotherapy in Locally Advanced Squamous Cell Carcinoma of the Larynx

Head &Neck, Volume 48, Issue 5, Page 1311-1318, May 2026.
ABSTRACT Background University of Michigan Cancer Center (UMCC) protocol 9520 treated stage III/IV locally advanced squamous cell carcinoma of the larynx (LASCCL) with cisplatin and 5‐fluorouracil to select for definitive therapy based on response.
Zachary Risch, Emily Bellile, Moneb S. Bughrara, Paul L. Swiecicki, Keith Casper, Kelly Malloy, Norman Hogikyan, Matthew Spector, Andrew Shuman, Chaz Stucken, Steven Chinn, Douglas C. Chepeha, Shruti Jolly, Michelle Mierzwa, Carol Bradford, Avraham Eisbruch, Thomas Carey, Mark Prince, Gregory T. Wolf, Francis P. Worden   +19 more
wiley   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, Volume 20, Issue 4, Page 1022-1040, April 2026.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Multiomics Research Strategies in Cancer: A Growing and Innovative Field

MedComm, Volume 7, Issue 4, April 2026.
This review highlights multiomics strategies in cancer research, focusing on integration methods from genomics to microbiomics. Using colorectal cancer as a key example, it discusses biomarker discovery, data integration via deep learning, and the roles of single‐cell and spatial omics.
Zhenhua Du, Xiaomei Liu, Zhi Lv, Bengang Wang, Yu Xia, Wala Abduljabbar Mohammed Al‐Duais, Lirong Yan, Fuqiang Zhang, Yanke Li   +8 more
wiley   +1 more source

Integrating artificial intelligence (AI) into colorectal cancer reporting

The Journal of Pathology, Volume 268, Issue 4, Page 367-382, April 2026.
Abstract Artificial intelligence (AI) and deep learning (DL) are transforming cancer research and clinical care, with histopathology playing a central role in this transformation. In colorectal cancer (CRC), the second leading cause of cancer mortality world‐wide, multimodal and vision‐language models (VLMs) hold particular promise for enhancing the ...
Konstantin Bräutigam, Ann‐Marie Baker, Viktor H Koelzer, Jakob N Kather, Trevor A Graham   +4 more
wiley   +1 more source

pH‐Dependent Microenvironmental Ionic Signaling in Pancreatic Ductal Adenocarcinoma

Acta Physiologica, Volume 242, Issue 4, April 2026.
ABSTRACT Aim Pancreatic ductal adenocarcinoma (PDAC) develops within a uniquely dynamic pH landscape shaped by substantial acid–base fluxes produced by the exocrine pancreas. Secretion of alkaline pancreatic juice, normally linked to digestion, produces intermittent acidifications of the pancreatic interstitium, which challenges epithelial and stromal ...
Albrecht Schwab, Micol Rugi, Pawel Swietach, Wiktoria Błaszczak, Ivana Novak, Ganga Deshar, Stine Falsig Pedersen, Renata Ialchina, Albin Sandelin, Jiayi Yao, Stephan J. Reshkin, Rosa A. Cardone, Tiago M. A. Carvalho, Annarosa Arcangeli, Rayhana Bouazzi, Franco N. D'Alessandro, Natalia Prevarskaya, Madelaine M. Audero, Halima Ouadid‐Ahidouch, Julie Schnipper, Luis A. Pardo, Xiaoyi Shi, Frauke Alves, Jakub Mitręga, Anna Trauzold, Sofie E. Hagelund, György Panyi, Marco Cozzolino, Clemens M. W. G. Löwik, Laura Mezzanotte, Roisin McMorrow, Andreas Pahl, Torsten Hechler, Elena Papacharisi, Alessandra Fiorio Pla, Ildiko Szabo, Verena Hofschröer, Zoltán Pethő   +37 more
wiley   +1 more source

Immune Cell Composition in Human Non-small Cell Lung Cancer

Frontiers in Immunology, 2019
Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related death in the world. Immunological analysis of the tumor microenvironment (immunoscore) shows great promise for improved prognosis and prediction of response to immunotherapy ...
Branislava Stankovic, Heidi Anine Korsmo Bjørhovde, Renate Skarshaug, Henrik Aamodt, Henrik Aamodt, Astri Frafjord, Elisabeth Müller, Clara Hammarström, Kahsai Beraki, Espen S. Bækkevold, Per Reidar Woldbæk, Åslaug Helland, Åslaug Helland, Åslaug Helland, Odd Terje Brustugun, Inger Øynebråten, Alexandre Corthay   +16 more
doaj   +1 more source