Results 71 to 80 of about 3,957 (191)

DataSheet_1_A nomogram based on collagen signature for predicting the immunoscore in colorectal cancer.docx

, 2023
ObjectivesThe Immunoscore can categorize patients into high- and low-risk groups for prognostication in colorectal cancer (CRC). Collagen plays an important role in immunomodulatory functions in the tumor microenvironment (TME).
Shuangmu Zhuo (320024), Dexin Chen (3949337), Gang Chen (107840), Jiaxin Cheng (10890039), Xiaoyu Dong (734222), Zexi Lin (16982295), Shuoyu Xu (10323323), Xian Yu (302651), Jun Yan (28467), Wei Jiang (14986), Chenyan Long (15460025), Botao Yan (16982292)   +11 more
core   +1 more source

Metabolic Profiling of Circulating and Tumour‐Infiltrating T Cells Uncovers Bioenergetic Checkpoints Linked With Immune and Clinical Skewing in Melanoma Patients

Immunology, Volume 179, Issue 3, Page 486-515, November 2026.
In this study, we revealed the disturbed metabolic status of circulating and tumour‐infiltrating CD4+ and CD8+ T cells in melanoma patients through targeted metabolomic and lipidomic (on sorted subsets) and at single cell level using the SCENITH method.
Hugo Brouque, Kareem Mahdy, Stephane Mouret, Sylvain Henry, Camille Niveau, Mélanie Cettour‐Cave, Martin Pelosse, Florence de Fraipont, Julie Charles, Andrei Turtoi, Philippe Saas, Caroline Aspord   +11 more
wiley   +1 more source

Immunoscore—has it scored for colon cancer precision medicine? [PDF]

Annals of Translational Medicine, 2018
For patients with early-stage resectable colon cancer, the principal method for determining prognosis is based on histopathological characterization of the tumor, including the depth of tumor penetration (T stage) and spread to nearby lymph nodes (N stage), with the American Joint Committee on Cancer (AJCC) staging system perhaps the most widely used ...
Robert N, Jorissen, Anuratha, Sakthianandeswaren, Oliver M, Sieber   +2 more
openaire   +2 more sources

Immunoscore®: A Diagnostic Assay for Clinical Management of Colon Cancer

, 2020
Compliance with Ethical Standards Funding The preparation of this review was not supported by any external funding. Conflict of interest Hannah Blair is a salaried employee of Adis International Ltd/Springer Nature, is responsible for the article ...
Hannah A. Blair (5008301)
core   +1 more source

In Vivo Immunoscoring Technique to Monitor Anti‐CD47 Immunotherapy Efficacy in Triple‐Negative Breast Cancer

Cancer Medicine, Volume 15, Issue 10, October 2026.
Intravital imaging using MCP1‐FITC and dextran‐AF680 assesses macrophage targeting and polarization in murine 4T1 tumor models. Visualization of M1‐like and M2‐like macrophages and M1/M2 ratio quantification support evaluation of anti‐CD47 immunotherapy, highlighting the potential of macrophage‐targeted imaging for patient stratification and treatment ...
Minfeng Yang, Shiqiang Hou, Chi Ming Wong, Hongzhao Chen, Chunjin Jin, Song‐Bai Liu, Jung Sun Yoo   +6 more
wiley   +1 more source

Expand to shield: IL-15 and in situ lymphocytic proliferation

OncoImmunology, 2021
The tumor microenvironment includes a complex network of cytokines and chemokines that contribute to shaping the intratumoral immune reaction. Understanding the mechanisms leading to immune-hot (Immunoscore-high) altered (excluded and immunosuppressed ...
Gabriela Bindea, Bernhard Mlecnik, Jérôme Galon   +2 more
doaj   +1 more source

Modified Immunoscore Improves Prediction of Survival Outcomes in Patients Undergoing Radical Cystectomy for Bladder Cancer—A Retrospective Digital Pathology Study

Diagnostics, 2022
To evaluate the prognostic value of a modified Immunoscore (mIS) in a cohort of bladder cancer (BC) patients undergoing radical cystectomy (RC), two tissue microarrays of 159 BC patients were immunohistochemically stained for CD3/CD8/FOXP3 and CD45RO to ...
Uwe Bieri, Lorenz Buser, Marian Severin Wettstein, Daniel Eberli, Karim Saba, Holger Moch, Thomas Hermanns, Cédric Poyet   +7 more
doaj   +1 more source

Prognostic significance of tumor microenvironment assessed by machine learning algorithm in surgically resected non‐small cell lung cancer

Cancer Reports, Volume 9, Issue 10, October 2026.
Abstract Background A methodology to assess the immune microenvironment (IME) of non‐small cell lung cancer (NSCLC) has not been established, and the prognostic impact of IME factors is not yet clear. Aims This study aimed to assess the IME factors and evaluate their prognostic values. Methods and Results We assessed CD8+ tumor‐infiltrating lymphocyte (
Yukihiro Terada, Mitsuhiro Isaka, Akira Ono, Takuya Kawata, Masakuni Serizawa, Keita Mori, Koji Muramatsu, Kiyoshi Tone, Hirotsugu Kenmotsu, Keiichi Ohshima, Kenichi Urakami, Takeshi Nagashima, Masatoshi Kusuhara, Yasuto Akiyama, Takashi Sugino, Toshiaki Takahashi, Yasuhisa Ohde   +16 more
wiley   +1 more source

An immunoscore nomogram for predicting survival in patients with oesophageal cancer

Aging, 2021
This study aimed to construct and validate an immunoscore nomogram that may be used to predict the prognosis of oesophageal cancer. With the gene expression data of oesophageal cancer in a public database, we used CIBERSORT to estimate the fractions of 22 infiltrating immune cell types.
Li, Gaoming, Song, Qiuyue, Cai, Angsong, Wei, Zeliang, Zhang, Rui, Yi, Dali, Chen, Jia, Li, Fang, Zhang, Yanqi, Liu, Ling, Wu, Yazhou, Yi, Dong   +11 more
openaire   +2 more sources

An Efficient Prognostic Immune Scoring System For Colorectal Cancer Patients With Peritoneal Metastasis

OncoImmunology, 2021
Immunoscore can accurately predict the prognosis of patients with stage I–III colorectal cancer. However, whether it can be used to predict the prognosis of colorectal cancer peritoneal metastases (CRCPM) remains to be validated.
Yamei Zhao, Chao Chen, Xiaoming Xu, Xiaoxu Ge, Kefeng Ding, Shu Zheng, Jian Wang, Lifeng Sun   +7 more
doaj   +1 more source