Results 61 to 70 of about 3,957 (191)

Molecular, spatial, and AI‐enabled technologies for predicting neoadjuvant therapy response in locally advanced rectal cancer

The Journal of Pathology, EarlyView.
Abstract Pretreatment prediction of neoadjuvant response remains an unresolved challenge in locally advanced rectal cancer, where management is moving towards risk‐adapted and response‐oriented treatment strategies. Prediction remains difficult because response reflects interacting tumour‐intrinsic, immune, stromal, and spatial processes that are ...
Gina F Boot, Cibele Masotti, Claudia Corrò, Cédric Schraepen, Hannah L Williams, Thomas A Wright, Fiza Ishaqwala, Colin W Steele, Gertjan Rasschaert, Maxime W Lafarge, Enric Domingo, Inti Zlobec, Rodrigo Oliva Perez, Campbell SD Roxburgh, Timothy S Maughan, Sabine Tejpar, Thibaud Koessler, Viktor H Koelzer   +17 more
wiley   +1 more source

Immunoscoring breast cancer: TILs remember what they target

Annals of Oncology, 2014
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G. Curigliano, E. A. Perez
openaire   +3 more sources

Biomarkers Predictive of Immunotherapy Efficacy in Head and Neck Squamous Cell Carcinoma: Current Insights and Future Perspectives

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT With the approval of immunotherapies by regulatory bodies, head and neck squamous cell carcinoma (HNSCC) treatment has been revolutionized, and anti‐programmed cell death‐1 (anti‐PD‐1) agents are now the standard for platinum‐resistant recurrent/metastatic HNSCC.
Xiao‐Tong Yan, Zhao‐Hong An, Chang‐Ming An   +2 more
wiley   +1 more source

Immunoscore: a new possible approach for melanoma classification [PDF]

Journal for ImmunoTherapy of Cancer, 2014
Meeting abstracts Increasing evidence has supported the hypothesis that cancer development is influenced by the host immune system. The number, type and location of the immune cells infiltrating the tumor microenvironment (TILs) may either limit or promote tumor progression [[1][1 ...
Capone, Mariaelena, Madonna, Gabriele, Sebastiao, Noemi, Bird, Jean, Ayala, Fabrizio, Caracò, Corrado, Ciliberto, Gennaro, La Fleur, Bonnie, Mozzillo, Nicola, Botti, Gerardo, Tubbs, Alisa, Ascierto, Paolo   +11 more
openaire   +1 more source

Supplementary Figure 2 from Prognostic and Predictive Values of the Immunoscore in Patients with Rectal Cancer

, 2014
To reinforce the confidence on the statistical analyses, patients with poor postoperative outcome (I0 and I1) were pooled. The Kaplan–Meier curves illustrate the DFS according to the Immunoscore and show significant differences between patient groups ...
Maria-Gabriela Anitei (14992050), Dan Ferariu (5106296), Christine Lagorce (14992062), Franck Pagès (10269071), Anne Berger (56603), Bernhard Mlecnik (56292), Nacilla Haicheur (14992056), Mihai Danciu (5447429), Jean-Marc Chevallier (2150890), Jérôme Galon (14906664), Franck Zinzindohoué (14992065), Gabriela Bindea (14896329), Patrick Bruneval (277054), Amos Kirilovsky (6085607), Ana-Maria Todosi (14992059), Guy Zeitoun (14992053), Florence Marliot (10879726), Viorel Scripcariu (7274402)   +17 more
core   +2 more sources

SLC7A3 Expression Is Associated With Migration, Invasion, and Survival in Oral Squamous Cell Carcinoma

Journal of Oral Pathology &Medicine, EarlyView.
ABSTRACT Background Oral squamous cell carcinoma (OSCC) is an aggressive malignancy with limited prognostic biomarkers, in which metabolic reprogramming contributes to tumor progression. Amino acid transporters of the solute carrier family have emerged as key regulators of cancer biology; however, the role of solute carrier family 7 member 3 (SLC7A3 ...
Lilianny Querino Rocha de Oliveira, Everton Freitas de Morais, Cintia Eliza Marques, Bruno Cesar da Costa, Fábio Haach Téo, Tuula Salo, Ricardo D. Coletta, Sabrina Daniela Silva Wurzba   +7 more
wiley   +1 more source

Application of the Immunoscore as prognostic tool for hepatocellular carcinoma

Journal for ImmunoTherapy of Cancer, 2016
To date, the American Joint Committee on Cancer (AJCC) and the Union for International Cancer Control (UICC) tumor, nodes, metastasis (TNM) classification represents the standard system for evaluation of prognosis in solid tumors. However, the clinical outcome can be significantly different in patients with the same TNM stage.
Annacarmen Petrizzo, Luigi Buonaguro
openaire   +3 more sources

Lachnospiraceae in the Food–Gut Axis: A Critical Review of Dietary Modulation, Immune Regulation, and Translational Barriers

Comprehensive Reviews in Food Science and Food Safety, Volume 25, Issue 6, November 2026.
ABSTRACT The interplay between diet, gut microbiota, and host immunity is central to food science. The Lachnospiraceae family ferments dietary fibers to produce short‐chain fatty acids (SCFAs), notably butyrate and propionate, with immunomodulatory potential. This critical review distinguishes established findings from hypotheses.
Ruijun Wang, Zhiqi Li, Lina Zhang, Yuanming Pan, Zhanbiao He   +4 more
wiley   +1 more source

Immunoscore predicts significant differences in time to recurrence in stage I colon cancer patients

, 2019
Immunoscore® is an in vitro diagnostic test that predicts the risk of relapse in patients with Colon Cancer (CC) by measuring the host immune response at the tumor site.
Kawakami, Y., Fox, B., Bifulco, C., Congress European Society for Medical Oncology 2019, Nagtegaal, I., Roehrl, M., Zavadova, E., Galon, J., Marincola, F., Ohashi, P., Marliot, F., Hartmann, A., Van den Eynde, Marc, Patel, P., Wang, Y., Hermitte, F., Ascierto, P., Torigoe, T., Pagès, F., Mlecnik, B., Lugli, A.   +20 more
core   +1 more source

Laryngeal Cancer Survival in Northern United Kingdom: A Multi‐Centre Retrospective Observational Study

Clinical Otolaryngology, Volume 51, Issue 6, Page 867-874, November 2026.
ABSTRACT Objectives Laryngeal cancer incidence has risen globally, yet survival outcomes have shown limited improvement over recent decades. This study evaluated contemporary outcomes across multiple centres in Northern UK and examined stage‐ and treatment‐specific survival. Design Multi‐centre retrospective observational study.
Amar Rajgor, Rhona Hurley, Catriona M. Douglas, Claire Paterson, James Moor, Shane Lester, Sara Sionis, Katherine Davies, James O’Hara, Gareth Inman, Terry Jones, David Winston Hamilton, Northern Head & Neck Alliance, Amarkumar Rajgor, Rhona Hurley, Catriona M. Douglas, Claire Paterson, James Moor, Shane Lester, Sara Sionis, Katherine Davies, James O'Hara, Gareth Inman, Terry Jones, David Winston Hamilton, Sarah Hill, Seamus O'Neill, Alison McLoughlin, Jemy Jose, Winson Wong, Michael Ho, Debbie Horne, Jarrod Homer, Matthew Kennedy, Emma Kinloch, Robert Metcalf, Iain Varley, Thomas Carroll, Sarah Healy, Helen Cocks, Michael Nugent, Leo Vassilou, Panos Kyzas, David Conway, John Greenman, Andrew Schache, Jason Fleming, Joanne Patterson, Keith Hunter, Paula Parvulescu, Rachel Brooker, Richard Shaw, Stephanie Meysner, Ola Rominiyi, Olena Mandrik   +54 more
wiley   +1 more source