Results 61 to 70 of about 3,200 (166)

World-Wide Immunoscore Task Force: meeting report from the “Melanoma Bridge”, Napoli, November 30th–December 3rd, 2016

Journal of Translational Medicine, 2017
The predictive accuracy of the traditional staging system is based on disease progression as a tumour cell-autonomous process, but it fails to incorporate the effects of the host immune response.
Jerome Galon, Alessandro Lugli, Carlo Bifulco, Franck Pages, Giuseppe Masucci, Francesco M. Marincola, Paolo A. Ascierto   +6 more
doaj   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, Volume 20, Issue 7, Page 1713-1725, July 2026.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Mutation profile and immunoscore signature in thymic carcinomas: An exploratory study and review of the literature

Thoracic Cancer, 2021
Background Significant efforts have been made to investigate the molecular pathways involved in thymic carcinogenesis. However, genetic findings have still not impacted clinical practice.
Rosanna Asselta, Luca Di Tommaso, Matteo Perrino, Annarita Destro, Laura Giordano, Giulia Cardamone, Luca Rubino, Armando Santoro, Stefano Duga, Paolo Andrea Zucali   +9 more
doaj   +1 more source

An analysis of sexual dimorphism in the tumor microenvironment of colorectal cancer

Frontiers in Oncology, 2022
Women with colorectal cancer (CRC) have survival advantages over men, yet the underlying mechanisms are unclear. T cell infiltration within the CRC tumor microenvironment (TME) correlates strongly with survival.
Andrea E. Geddes, Anita L. Ray, Robert A. Nofchissey, Azadeh Esmaeili, Apryl Saunders, Dawn E. Bender, Maaz Khan, Sheeja Aravindan, Jared T. Ahrendsen, Min Li, Min Li, Kar-Ming Fung, Kar-Ming Fung, Muralidharan Jayaraman, Muralidharan Jayaraman, Jingxuan Yang, Kristina K. Booth, Gary D. Dunn, Steven N. Carter, Katherine T. Morris   +19 more
doaj   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, Volume 20, Issue 6, Page 1535-1555, June 2026.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Immunoscore: a new possible approach for melanoma classification [PDF]

Journal for ImmunoTherapy of Cancer, 2014
Meeting abstracts Increasing evidence has supported the hypothesis that cancer development is influenced by the host immune system. The number, type and location of the immune cells infiltrating the tumor microenvironment (TILs) may either limit or promote tumor progression [[1][1 ...
Capone, Mariaelena, Madonna, Gabriele, Sebastiao, Noemi, Bird, Jean, Ayala, Fabrizio, Caracò, Corrado, Ciliberto, Gennaro, La Fleur, Bonnie, Mozzillo, Nicola, Botti, Gerardo, Tubbs, Alisa, Ascierto, Paolo   +11 more
openaire   +1 more source

Impact of PD-L1 and PD-1 Expression on the Prognostic Significance of CD8+ Tumor-Infiltrating Lymphocytes in Non-Small Cell Lung Cancer

Frontiers in Immunology, 2021
The immune infiltrate within tumors has proved to be very powerful in the prognostic stratification of patients and much attention is also being paid towards its predictive value.
Enrico Munari, Enrico Munari, Marcella Marconi, Giulia Querzoli, Gianluigi Lunardi, Pietro Bertoglio, Francesco Ciompi, Alice Tosadori, Albino Eccher, Nicola Tumino, Linda Quatrini, Paola Vacca, Giulio Rossi, Alberto Cavazza, Guido Martignoni, Guido Martignoni, Matteo Brunelli, George J. Netto, Lorenzo Moretta, Giuseppe Zamboni, Giuseppe Zamboni, Giuseppe Bogina   +21 more
doaj   +1 more source

Mapping Immunity With Cutting‐Edge Spatial Biology and Tissue Cytometry Innovations

MedComm, Volume 7, Issue 6, June 2026.
This review explores how spatial biology integrates multiplexed imaging and tissue cytometry to reveal immune organization within native tissue contexts. ABSTRACT The immune system operates within organized tissue landscapes, where spatial relationships between cells shape the nature and outcome of immune responses.
Lilibeth Cárdenas‐Piedra, Selwin G. Samuel, Felicitas Mungenast, Dinesh Yasothkumar, Rupert C. Ecker, Jyotsna Batra   +5 more
wiley   +1 more source

Multiverse of immune microenvironment in metastatic colorectal cancer

OncoImmunology, 2020
The comprehensive analysis of patients with a complete resection of all metastases reveals the heterogeneity of the colorectal metastatic disease and its clinical impact.
Marc Van den Eynde, Bernhard Mlecnik, Gabriela Bindea, Jérôme Galon   +3 more
doaj   +1 more source

Genetic Alterations in the SERPIN Gene Family as Predictors of Immune Checkpoint Therapy Efficacy in Melanoma and Non‐Small Cell Lung Cancer

Medicine Advances, Volume 4, Issue 2, Page 235-245, June 2026.
This study demonstrated a clear association between serine protease inhibitor (SERPIN) gene alterations and clinical outcomes in patients with melanoma and non‐small cell lung cancer receiving immune checkpoint inhibitor therapy across five cohorts.
Jieqiong Li, Di Wang, Yuxin Wang, Lixia Wang, Jinmei Luo, Yi Xiao   +5 more
wiley   +1 more source