Results 41 to 50 of about 3,200 (166)

Analyses of Pretherapy Peripheral Immunoscore and Response to Vaccine Therapy [PDF]

Cancer Immunology Research, 2016
Abstract Tumor immunoscore analyses, especially for primary colorectal cancer and melanoma lesions, provide valuable prognostic information. Metastatic lesions of many carcinoma types, however, are often not easily accessible. We hypothesized that immune cells in peripheral blood may differ among individual patients with metastatic ...
Benedetto, Farsaci, Renee N, Donahue, Italia, Grenga, Lauren M, Lepone, Peter S, Kim, Brendan, Dempsey, Janet C, Siebert, Nuhad K, Ibrahim, Ravi A, Madan, Christopher R, Heery, James L, Gulley, Jeffrey, Schlom   +11 more
openaire   +2 more sources

Colorectal Cancer Immune Infiltrates: Significance in Patient Prognosis and Immunotherapeutic Efficacy

Frontiers in Immunology, 2020
Colorectal cancer occurrence and progression involve multiple aspects of host immune deficiencies. In these events, immune cells vary their phenotypes and functions over time, thus enabling the immune microenvironment to be “tumor-inhibiting” as well as “
Liang Guo, Chuanlei Wang, Xiang Qiu, Xiaoyu Pu, Pengyu Chang, Pengyu Chang, Pengyu Chang   +6 more
doaj   +1 more source

Polymorphonuclear Myeloid-Derived Suppressor Cells Are Abundant in Peripheral Blood of Cancer Patients and Suppress Natural Killer Cell Anti-Tumor Activity

Frontiers in Immunology, 2022
Tumor microenvironment (TME) includes a wide variety of cell types and soluble factors capable of suppressing immune-responses. While the role of NK cells in TME has been analyzed, limited information is available on the presence and the effect of ...
Nicola Tumino, Francesca Besi, Stefania Martini, Anna Laura Di Pace, Enrico Munari, Enrico Munari, Linda Quatrini, Andrea Pelosi, Piera Filomena Fiore, Giulia Fiscon, Giulia Fiscon, Paola Paci, Paola Paci, Francesca Scordamaglia, Maria Grazia Covesnon, Giuseppe Bogina, Maria Cristina Mingari, Maria Cristina Mingari, Lorenzo Moretta, Paola Vacca   +19 more
doaj   +1 more source

Prognostic Impact of YKL-40 Immunohistochemical Expression in Patients with Colorectal Cancer

Current Oncology, 2021
This study aims to examine the clinicopathological and prognostic significance of the YKL-40 immunohistochemical expression of tumor and immune cells through human colorectal cancer (CRC) tissue.
Il Hwan Oh, Jung-Soo Pyo, Byoung Kwan Son   +2 more
doaj   +1 more source

Immunoscore in mismatch repair‐proficient and ‐deficient colon cancer

The Journal of Pathology: Clinical Research, 2017
AbstractThe aim of this study was to investigate immune response and its prognostic significance in colon carcinomas using the previously described Immunoscore (IS). A population‐based series of 779 colorectal cancers, operated on between 2000 and 2010, were classified according to tumour, node, metastasis (TNM) status, mismatch repair (MMR), and BRAF ...
Wirta, Erkki-Ville, Seppälä, Toni, Friman, Marjukka, Väyrynen, Juha, Ahtiainen, Maarit, Kautiainen, Hannu, Kuopio, Teijo, Kellokumpu, Ilmo, Mecklin, Jukka-Pekka, Böhm, Jan   +10 more
openaire   +6 more sources

Gene expression profiles for a prognostic immunoscore in gastric cancer [PDF]

British Journal of Surgery, 2018
AbstractBackgroundIncreasing evidence has indicated an association between immune infiltration in gastric cancer and clinical outcome. However, reliable prognostic signatures, based on systematic assessments of the immune landscape inferred from bulk tumour transcriptomes, have not been established.
Zeng, D., Zhou, R., Yu, Y., Luo, Y., Zhang, J., Sun, H., Bin, J., Liao, Y., Rao, J., Zhang, Y., Liao, W.   +10 more
openaire   +2 more sources

The landscape and prognostic value of tumor-infiltrating immune cells in gastric cancer [PDF]

PeerJ, 2019
Background Gastric cancer (GC) is the fourth most frequently diagnosed malignancy and the second leading cause of cancer-associated mortality worldwide.
Linhai Li, Yiming Ouyang, Wenrong Wang, Dezhi Hou, Yu Zhu   +4 more
doaj   +2 more sources

The consensus Immunoscore in phase 3 clinical trial (N0147) and impact on patient management decisions

OncoImmunology, 2020
The consensus Immunoscore is a routine assay quantifying the adaptive immune response within the tumor microenvironment. It has a prognostic value that has been confirmed in a phase 3 clinical trial (NCCTG N0147) in stage III colon cancers.
Anastasia Lanzi, F. A. Sinicrope, A. B. Benson, Jérôme Galon   +3 more
doaj   +1 more source

Prognostic Implications of Intratumoral and Peritumoral Infiltrating Lymphocytes in Pancreatic Ductal Adenocarcinoma

Current Oncology, 2021
This study aimed to elucidate the prognostic implications of intratumoral and peritumoral infiltrating T-lymphocytes in pancreatic ductal adenocarcinoma (PDAC) through a meta-analysis.
Jung-Soo Pyo, Byoung Kwan Son, Hyo Young Lee, Il Hwan Oh, Kwang Hyun Chung   +4 more
doaj   +1 more source

A nomogram-based immune-serum scoring system predicts overall survival in patients with lung adenocarcinoma

Cancer Biology & Medicine, 2021
Objective: The immunoscore, which is used to quantify immune infiltrates, has greater relative prognostic value than tumor, node, and metastasis (TNM) stage and might serve as a new system for classification of colorectal cancer.
Qiujuan Huang, Tongyuan Qu, Lisha Qi, Changxu Liu, Yuhong Guo, Qianru Guo, Guangning Li, Yalei Wang, Wenshuai Zhang, Wei Zhao, Danyang Ren, Leina Sun, Shengguang Wang, Bin Meng, Baocun Sun, Bin Zhang, Wenjuan Ma, Wenfeng Cao   +17 more
doaj   +1 more source