Results 21 to 30 of about 3,957 (191)
Recent Advances in Peripheral Immunoscore in Lung Cancer
Zhongguo fei ai za zhi = Chinese journal of lung cancerLung cancer is the malignant tumor with the highest morbidity and mortality. The tumor-node-metastasis (TNM) staging has gradually shown its limitations in the accurate prediction of lung cancer, so it is urgent to construct a new clinical predictive ...Zhenyang CHENG, Fan XU, Bin LUO, Youjun LIU, Yun YANG, Jianhui TIAN +5 morecore +4 more sourcesMulticenter International Study of the Consensus Immunoscore for the Prediction of Relapse and Survival in Early-Stage Colon Cancer [PDF]
, 2023 Background: The prognostic value of Immunoscore was evaluated in Stage II/III colon cancer (CC) patients, but it remains unclear in Stage I/II, and in early-stage subgroups at risk.Michal Vocka, MacGregor, Heather L, Carmen Ballesteros-Merino, Patel, Jayendrakumar B., Zavadova, Eva, Noriyuki Sato, Merkel, Susanne, Maio, Michele, Nagtegaal, Iris D., Francesco M. Marincola, Gerardo Botti, Carlo Bifulco, Xu, Mingli, Jan Spacek, Marincola, Francesco M., Botti, Gerardo, Hijazi, Assia, Rau, Tilman T, Bifulco, Carlo, Kartheuser, Alex, Bavi, Prashant, Nemejcova, Kristyna, Vliet, Shannon van Lent-van, SeongJun Han, Christine Lagorce, Daniel Léonard, Fox, Bernard A, Ciliberto, Gennaro, Rau, Tilman T., Boryana Popivanova, Geppert, Carol I., Nguyen, Linh T., Hiroaki Nagano, Shah, Birva, Christopher Paustian, Shoichi Hazama, Dundr, Pavel, Petruzelka, Lubos, Jeroen Dijkstra, Prashant Bavi, Berger, Martin D, Shukla, Shilin N, Lafontaine, Lucie, Van den Eynde, Marc, Tilman T. Rau, Elisa Vink-Börger, Susanne Merkel, Ohashi, Pamela S, Shannon van Lent-van Vliet, Masucci, Giuseppe V., Giuseppe V. Masucci, Han, SeongJun, Galon, Jérôme, Tomohisa Furuhata, Bernhard Mlecnik, Kolwelter, Julie, Vora, Hemangini H, Carine El Sissy, Pauline Maby, Dragos Viorel Scripcariu, Marincola, Francesco M, Mourin, Anne, Patel, Jayendrakumar B, Marliot, Florence, Fabio Grizzi, Julie Kolwelter, Birva Shah, Sato, Noriyuki, Kawakami, Yutaka, Nguyen, Linh T, Lagorce, Christine, Geppert, Carol I, Alex Kartheuser, Jérôme Galon, Furuhata, Tomohisa, Pagès, Franck, Andersson, Emilia K., Jouret-Mourin, Anne, Mușină, Ana-Maria, Buttard, Bénédicte, Ichiro Takemasa, Michael Roehrl, Torigoe, Toshihiko, J. Jack Lee, Tatangelo, Fabiana, Laghi, Luigi, Jayendrakumar B. Patel, Mlecnik, Bernhard, Rajvik, Kruti N, Zhang, Guanjun, Yili Wang, Jiun-Kae Jack Lee, Wouters, Bradly G, Spacek, Jan, Ascierto, Paolo A., Vocka, Michal, Bohuslav Konopasek, Fujita, Tomonobu, Michael H. A. Roehrl, Léonard, Daniel, Dijkstra, Jeroen, El Sissy, Carine, Majdi, Amine, Hemangini H. Vora, Kirilovsky, Amos, Amos Kirilovsky, Ballesteros-Merino, Carmen, Anne Jouret-Mourin, Prabhu Patel, Hartmann, Arndt, Knijn, Nikki, Grizzi, Fabio, Masucci, Giuseppe V, Bindea, Gabriela, Delrio, Paolo, Hazama, Shoichi, Amine Majdi, Ohashi, Pamela S., Okuno, Kiyotaka, Fabiana Tatangelo, Tilman Rau, Guanjun Zhang, Ascierto, Paolo A, Vora, Hemangini H., Kiyotaka Okuno, Sara Hafezi-Bakhtiari, Lubos Petruzelka, Pandya, Shashank J, Fredriksen, Tessa, Wang, Yili, Kristyna Nemejcova, Berger, Martin D., Lugli, Alessandro, Dragos-Viorel Scripcariu, Kruti N. Rajvik, Shukla, Shilin N., Shashank J. Pandya, Iris D. Nagtegaal, Bénédicte Buttard, Nikki Knijn, Bernard A. Fox, Zlobec, Inti, Berger, Anne, Wouters, Bradly G., Yutaka Kawakami, Pamela S. Ohashi, Anne Berger, Robert Grützmann, Grützmann, Robert, Giuseppe Masucci, Lucie Lafontaine, Christophe Remue, Paustian, Christopher, Tomonobu Fujita, Mingli Xu, Popivanova, Boryana, Luigi Laghi, Michele Maio, Hafezi-Bakhtiari, Sara, Fox, Bernard A., Vink-Börger, Elisa, Francesco Marincola, Gennaro Ciliberto, Gabriela Bindea, Carol I. Geppert, Scripcariu, Dragos-Viorel, Alessandro Lugli, Toshihiko Torigoe, Nagano, Hiroaki, Pavel Dundr, Rajvik, Kruti N., Nagtegaal, Iris D, Skalova, Helena, Bradly G. Wouters, Roehrl, Michael H A, Ana-Maria Mușină, Shilin N. Shukla, Patel, Prabhu, Pandya, Shashank J., Roehrl, Michael H. A., Tessa Fredriksen, Wang, Julia, Franck Pagès, Andersson, Emilia K, Florence Marliot, Julia Wang, Linh T. Nguyen, Inti Zlobec, Paolo A. Ascierto, Nobuaki Suzuki, Assia Hijazi, Maby, Pauline, van de Water, Carlijn, Paolo Delrio, Marc Van den Eynde, Emilia K. Andersson, Remue, Christophe, Helena Skalova, Carlijn van de Water, Eva Zavadova, Suzuki, Nobuaki, Martin D. Berger, Heather L. MacGregor, Lee, Jiun-Kae Jack, Konopasek, Bohuslav, Takemasa, Ichiro, Arndt Hartmann, MacGregor, Heather L. +207 morecore +5 more sourcesThe Immunoscore: Colon Cancer and Beyond [PDF]
Clinical Cancer Research, 2020 AbstractTumors evolve in close interaction with their microenvironment, which encompasses a continual tension between the developing tumor and the host immune system. Clinical trials have shown that appropriate enhancement of a tumor immune response can lead to long-lasting clinical responses and patient benefit.Helen K. Angell, Daniela Bruni, J. Carl Barrett, Ronald Herbst, Jérôme Galon +4 moreopenaire +2 more sourcesTherapeutic Implications of the Immunoscore in Patients with Colorectal Cancer [PDF]
Cancers, 2021 Four decades were needed to progress from the first demonstration of the independent prognostic value of lymphocytes infiltration in rectal cancers to the first recommendation from the international guidelines for the use of a standardized immune assay, namely the “Immunoscore” (IS), to accurately prognosticate colon cancers beyond the TNM-system.El Sissy, Carine, Kirilovsky, Amos, Zeitoun, Guy, Marliot, Florence, Haicheur, Nacilla, Lagorce-Pagès, Christine, Galon, Jérôme, Pagès, Franck +7 moreopenaire +3 more sourcesDissecting tumor lymphocyte infiltration to predict benefit from immune-checkpoint inhibitors in metastatic colorectal cancer: lessons from the AtezoT RIBE study
Journal for ImmunoTherapy of Cancer, 2023 Background Tumor immune cells influence the efficacy of immune-checkpoint inhibitors (ICIs) and many efforts aim at identifying features of tumor immune microenvironment able to predict benefit from ICIs in proficient mismatch repair (pMMR ...Chiara Cremolini, Daniele Rossini, Sara Lonardi, Filippo Pietrantonio, Gianluca Masi, Roberto Moretto, Alessandra Boccaccino, Jerome Galon, Jacques Fieschi, Stefano Tamberi, Gabriella Fontanini, Lisa Salvatore, Clara Ugolini, Alboukadel Kassambara, Emiliano Tamburini, Veronica Conca, Aurélie Catteau, Carlotta Antoniotti, Mirella Giordano, Agnese Proietti, Anello Marcello Poma +20 moredoaj +1 more sourceTumor-infiltrating lymphocytes and macrophages as a significant prognostic factor in biliary tract cancer.
PLoS ONE, 2023 BackgroundThe impact of tumor-infiltrating lymphocytes (TILs) and tumor-associated macrophages (TAMs) on the prognosis of biliary tract cancer (BTC) is not completely understood.Ryota Tanaka, Shimpei Eguchi, Kenjiro Kimura, Go Ohira, Shogo Tanaka, Ryosuke Amano, Hiroaki Tanaka, Masakazu Yashiro, Masaichi Ohira, Shoji Kubo +9 moredoaj +2 more sourcesInterrogating the immune landscape of microsatellite stable RAS-mutated colon cancer. [PDF]
Mol OncolCOLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...Dienstmann R, García-Galea E, O'Farrell A, Kinsella Z, Meylan M, Petitprez F, Arijs I, Venken T, Ps H, Lärkeryd A, Miller I, Selves J, Meindl-Beinker N, Ruiz-Pace F, Élez E, Comas-Navarro R, Lincoln F, Fey D, Nyamundanda G, Nolan A, Lewin J, Perez-Lopez R, Briody J, Bennett K, Kolch W, Matallanas D, Kel A, Arenas E, Arribas J, Ghesquière B, Tabernero J, Meilleroux J, McNamara D, McDermott R, Lim M, O'Reilly M, Bird B, Stack L, Moloney L, Morris P, Egan K, Milewski M, Scheuer L, Behringer J, Bolz G, Salazar R, Santos C, Ruiz A, Casey O, Murphy V, Ebert M, Trusolino L, Lambrechts D, Sadanandam A, Sautès-Fridman C, Prehn J, Nuciforo P, Fieschi J, Monville F, O'Connor D, Fridman W, Byrne A. +61 moreeuropepmc +2 more sourcesPrognostic Value of Immunoscore in Colorectal Carcinomas
International Journal of Surgical Pathology, 2022 Abstract Background Immunoscore (IS), based on the evaluation of CD3 + and CD8 + densities in the center of the tumor (CT) and its invasive margin (IM), is currently considered as a potential prognostic factor, particularly in colorectal carcinomas (CRC). In the current study, we aimed to assess the prognostic value of IS in CRC stage I to IV, Helal Imen, Hmidi Amira, Khanchel Fatma, Jouini Raja, Sabbah Mariem, Zaafouri Haithem, Ben Brahim Ehsene, Chadlidebbiche Aschraf +7 moreopenaire +2 more sourcesThe “Immunoscore” in rectal cancer: could we search quality beyond quantity of life? [PDF]
Oncotarget, 2022 Because of the function and anatomical environment of the rectum, therapeutic strategies for local advanced rectal cancer (LARC) must deal with two challenging stressors that are a high-risk of local and distal recurrences and a high-risk of poor quality of life (QoL).Kirilovsky, Amos, El Sissy, Carine, Zeitoun, Guy, Marliot, Florence, Haicheur, Nacilla, Lagorce-Pagès, Christine, Taieb, Julien, Karoui, Mehdi, Custers, Petra, Dizdarevic, Edina, Iseas, Soledad, Hansen, Torben, Jensen, Lars, Beets, Geerard, Gérard, Jean, Castillo-Martin, Mireia, Figueiredo, Nuno, Habr-Gama, Angelita, Perez, Rodrigo, Galon, Jérôme, Pagès, Franck +20 moreopenaire +5 more sources mutation and Immunoscore
, 2021 Surgical resection of colorectal liver metastases combined with systemic treatment aims to maximize patient survival. However, recurrence rates are very high postsurgery.Benoît Navez, Pagès, Franck, Pamela Baldin, Tessa Fredriksen, Franck Pagès, Catherine Hubert, Florence Marliot, Fredriksen, Tessa, Anne Jouret‐Mourin, Jouret-Mourin, Anne, Navez, Benoît, Nicolas Huyghe, Galon, Jérôme, Bernhard Mlecnik, Nicolas Lanthier, Marc Van den Eynde, Gabriela Bindea, Carrasco, Javier, Gabriela Beniuga, Mlecnik, Bernhard, Mina Komuta, Marliot, Florence, Bindea, Gabriela, Beniuga, Gabriela, Nacilla Haicheur, Lafontaine, Lucie, Haicheur, Nacilla, Hubert, Catherine, Huyghe, Nicolas, Javier Carrasco, Lanthier, Nicolas, Van den Eynde, Marc, Lucie Lafontaine, Baldin, Paméla, Komuta, Mina, Jérôme Galon +35 morecore +1 more source
