Results 11 to 20 of about 3,200 (166)

The consensus immunoscore: toward a new classification of colorectal cancer [PDF]

OncoImmunology, 2020
In its latest edition, the WHO classification of the Digestive System Tumors introduced for the first time the immune response as essential and desirable diagnostic criteria for colorectal cancer.
Jérôme Galon, Pages Franck
exaly   +4 more sources

Prognostic and Predictive Value of an Immunoscore Signature in Glioblastoma Multiform [PDF]

Frontiers in Genetics, 2020
BackgroundAlthough increasing evidence shows that immune infiltration plays an essential role in glioblastoma (GBM), current prognostic indicators do not accurately represent the risk of immune cells infiltration in patients.
Xiangjun Tang, Xiangjun Tang, Pengfei Xu, Ann Chen, Gang Deng, Shenqi Zhang, Lun Gao, Longjun Dai, Qianxue Chen   +8 more
doaj   +3 more sources

Association of artificial intelligence-based immunoscore with the efficacy of chemoimmunotherapy in patients with advanced non-squamous non-small cell lung cancer: a multicentre retrospective study [PDF]

Frontiers in Immunology
PurposeCurrently, chemoimmunotherapy is effective only in a subset of patients with advanced non-squamous non-small cell lung cancer. Robust biomarkers for predicting the efficacy of chemoimmunotherapy would be useful to identify patients who would ...
Jiaqing Liu, Jiaqing Liu, Jiaqing Liu, Jiaqing Liu, Dongchen Sun, Dongchen Sun, Dongchen Sun, Dongchen Sun, Shuoyu Xu, Jiayi Shen, Jiayi Shen, Jiayi Shen, Jiayi Shen, Wenjuan Ma, Wenjuan Ma, Wenjuan Ma, Wenjuan Ma, Huaqiang Zhou, Huaqiang Zhou, Huaqiang Zhou, Huaqiang Zhou, Yuxiang Ma, Yuxiang Ma, Yuxiang Ma, Yuxiang Ma, Yaxiong Zhang, Yaxiong Zhang, Yaxiong Zhang, Yaxiong Zhang, Wenfeng Fang, Wenfeng Fang, Wenfeng Fang, Wenfeng Fang, Yuanyuan Zhao, Yuanyuan Zhao, Yuanyuan Zhao, Yuanyuan Zhao, Shaodong Hong, Shaodong Hong, Shaodong Hong, Shaodong Hong, Jianhua Zhan, Jianhua Zhan, Jianhua Zhan, Jianhua Zhan, Xue Hou, Xue Hou, Xue Hou, Xue Hou, Hongyun Zhao, Hongyun Zhao, Hongyun Zhao, Hongyun Zhao, Yan Huang, Yan Huang, Yan Huang, Yan Huang, Bingdou He, Yunpeng Yang, Yunpeng Yang, Yunpeng Yang, Yunpeng Yang, Li Zhang, Li Zhang, Li Zhang, Li Zhang   +65 more
doaj   +2 more sources

Association of the tumor microenvironment collagen score and immunoscore with colon cancer lymph node metastasis [PDF]

BMC Cancer
Background In clinical practice, lymph node status has an important impact on colon cancer (CC) management and treatment. The role of the tumor microenvironment collagen score and immunoscore in colon cancer lymph node metastasis remains unknown. Methods
Chenyan Long, Jiaxin Cheng, Mingyuan Feng, Botao Yan, Yiran Li, Wei Jiang, Dexin Chen, Jun Yan   +7 more
doaj   +2 more sources

The Immunoscore: Colon Cancer and Beyond [PDF]

Clinical Cancer Research, 2020
AbstractTumors evolve in close interaction with their microenvironment, which encompasses a continual tension between the developing tumor and the host immune system. Clinical trials have shown that appropriate enhancement of a tumor immune response can lead to long-lasting clinical responses and patient benefit.
Helen K. Angell, Daniela Bruni, J. Carl Barrett, Ronald Herbst, Jérôme Galon   +4 more
openaire   +2 more sources

Therapeutic Implications of the Immunoscore in Patients with Colorectal Cancer [PDF]

Cancers, 2021
Four decades were needed to progress from the first demonstration of the independent prognostic value of lymphocytes infiltration in rectal cancers to the first recommendation from the international guidelines for the use of a standardized immune assay, namely the “Immunoscore” (IS), to accurately prognosticate colon cancers beyond the TNM-system.
El Sissy, Carine, Kirilovsky, Amos, Zeitoun, Guy, Marliot, Florence, Haicheur, Nacilla, Lagorce-Pagès, Christine, Galon, Jérôme, Pagès, Franck   +7 more
openaire   +3 more sources

Dissecting tumor lymphocyte infiltration to predict benefit from immune-checkpoint inhibitors in metastatic colorectal cancer: lessons from the AtezoT RIBE study

Journal for ImmunoTherapy of Cancer, 2023
Background Tumor immune cells influence the efficacy of immune-checkpoint inhibitors (ICIs) and many efforts aim at identifying features of tumor immune microenvironment able to predict benefit from ICIs in proficient mismatch repair (pMMR ...
Chiara Cremolini, Daniele Rossini, Sara Lonardi, Filippo Pietrantonio, Gianluca Masi, Roberto Moretto, Alessandra Boccaccino, Jerome Galon, Jacques Fieschi, Stefano Tamberi, Gabriella Fontanini, Lisa Salvatore, Clara Ugolini, Alboukadel Kassambara, Emiliano Tamburini, Veronica Conca, Aurélie Catteau, Carlotta Antoniotti, Mirella Giordano, Agnese Proietti, Anello Marcello Poma   +20 more
doaj   +1 more source

Tumor-infiltrating lymphocytes and macrophages as a significant prognostic factor in biliary tract cancer.

PLoS ONE, 2023
BackgroundThe impact of tumor-infiltrating lymphocytes (TILs) and tumor-associated macrophages (TAMs) on the prognosis of biliary tract cancer (BTC) is not completely understood.
Ryota Tanaka, Shimpei Eguchi, Kenjiro Kimura, Go Ohira, Shogo Tanaka, Ryosuke Amano, Hiroaki Tanaka, Masakazu Yashiro, Masaichi Ohira, Shoji Kubo   +9 more
doaj   +2 more sources

Prognostic Impact of Immunoscore in Pathological Stage III Differentiated Gastric Cancer: A Multicenter Cohort Study Including PD-L1/PD-L2 Expression Analysis. [PDF]

Ann Gastroenterol Surg
We assessed the prognostic ability of the Immunoscore and PD‐L1 or PD‐L2 expression in pStage III GC patients by immunohistochemistry. The results showed that Immunoscore was an independent prognostic factor in differentiated GC, but not in undifferentiated GC.
Yukawa Y, Saito T, Kurokawa Y, Akamaru Y, Kidogami S, Imamura H, Fujitani K, Matsuyama J, Yamamoto K, Takahashi T, Matsui T, Morii E, Eguchi H, Doki Y.   +13 more
europepmc   +2 more sources

Prognostic significance of tumor microenvironment assessed by machine learning algorithm in surgically resected non‐small cell lung cancer

Cancer Reports, EarlyView., 2023
Abstract Background A methodology to assess the immune microenvironment (IME) of non‐small cell lung cancer (NSCLC) has not been established, and the prognostic impact of IME factors is not yet clear. Aims This study aimed to assess the IME factors and evaluate their prognostic values. Methods and Results We assessed CD8+ tumor‐infiltrating lymphocyte (
Yukihiro Terada, Mitsuhiro Isaka, Akira Ono, Takuya Kawata, Masakuni Serizawa, Keita Mori, Koji Muramatsu, Kiyoshi Tone, Hirotsugu Kenmotsu, Keiichi Ohshima, Kenichi Urakami, Takeshi Nagashima, Masatoshi Kusuhara, Yasuto Akiyama, Takashi Sugino, Toshiaki Takahashi, Yasuhisa Ohde   +16 more
wiley   +1 more source