Results 31 to 40 of about 3,200 (166)

Immunoscore as a prognostic marker in colorectal cancer [PDF]

Folia Medica
Introduction: Colorectal cancer is a leading cause of morbidity and mortality worldwide. Immunoscore provides important prognostic information in early-stage colorectal cancer, beyond traditional TNM staging.
Yanislav Grishev Iliev, Vladimir Nikolov Andonov, Elena Galabova Poryazova-Markova   +2 more
doaj   +3 more sources

The consensus Immunoscore in phase 3 clinical trials; potential impact on patient management decisions

OncoImmunology, 2020
The consensus Immunoscore has a prognostic value that has been confirmed in two randomized phase 3 clinical trials, and it provides a reliable estimate of the recurrence risk in colon cancer.
Franck Pagès, Julien Taieb, Pierre Laurent-Puig, Jérôme Galon   +3 more
doaj   +1 more source

A prognostic value of CD45RA+, CD45RO+, CCL20+ and CCR6+ expressing cells as ‘immunoscore’ to predict cervical cancer induced by HPV

Scientific Reports, 2021
The interplay between cervical cancer (CC) and immune cells, mainly intratumoral lymphocytes, has a pivotal role in carcinogenesis. In this context, we evaluated the distribution of CD45RA+ and CD45RO+ cells as well as CCR6+ and CCL20+ cells in ...
Ana Teresa G. Fernandes, Maria Odete O. Carvalho, Elyzabeth Avvad-Portari, Natália P. Rocha, Fabio Russomano, Eric Henrique Roma, Maria da Gloria Bonecini-Almeida   +6 more
doaj   +1 more source

Immunoscore Combining CD8, FoxP3, and CD68-Positive Cells Density and Distribution Predicts the Prognosis of Head and Neck Cancer Patients

Cells, 2022
We assessed immune cell infiltrates to develop an immunoscore for prognosis and to investigate its correlation with the clinical data of patients with head and neck cancer.
Sonia Furgiuele, Géraldine Descamps, Jerome R. Lechien, Didier Dequanter, Fabrice Journe, Sven Saussez   +5 more
doaj   +1 more source

Profiles of Immune Infiltration and Prognostic Immunoscore in Lung Adenocarcinoma [PDF]

BioMed Research International, 2020
Lung tissue is abundant with immune cells that form a powerful first defense against exotic particles and microbes. The malignant phenotype of lung adenocarcinoma (LUAD) is defined not only by intrinsic tumor cells but also by tumor‐infiltrating immune cells (TIICs) recruited to the immune microenvironment.
Yanyan Li, Liping Tao, Weiyang Cai
openaire   +2 more sources

Clinicopathological Features Combined With Immune Infiltration Could Well Distinguish Outcomes in Stage II and Stage III Colorectal Cancer: A Retrospective Study

Frontiers in Oncology, 2021
BackgroundThe Immunoscore predicts prognosis in patients with colorectal cancer (CRC). However, a few studies have incorporated the Immunoscore into the construction of comprehensive prognostic models in CRC, especially stage II CRC.
Jiazi Ren, Linfeng Xu, Linfeng Xu, Siyu Zhou, Jian Ouyang, Weiqiang You, Nengquan Sheng, Li Yan, Du Peng, Lu Xie, Zhigang Wang   +10 more
doaj   +1 more source

Cancer classification using the Immunoscore: a worldwide task force [PDF]

Journal of Translational Medicine, 2012
Prediction of clinical outcome in cancer is usually achieved by histopathological evaluation of tissue samples obtained during surgical resection of the primary tumor. Traditional tumor staging (AJCC/UICC-TNM classification) summarizes data on tumor burden (T), presence of cancer cells in draining and regional lymph nodes (N) and evidence for ...
Galon, Jérôme, Pagès, Franck, Marincola, Francesco, Angell, Helen, Thurin, Magdalena, Lugli, Alessandro, Zlobec, Inti, Berger, Anne, Bifulco, Carlo, Botti, Gerardo, Tatangelo, Fabiana, Britten, Cedrik, Kreiter, Sebastian, Chouchane, Lotfi, Delrio, Paolo, Arndt, Hartmann, Asslaber, Martin, Maio, Michele, Masucci, Giuseppe, Mihm, Martin, Vidal-Vanaclocha, Fernando, Allison, James, Gnjatic, Sacha, Hakansson, Leif, Huber, Christoph, Singh-Jasuja, Harpreet, Ottensmeier, Christian, Zwierzina, Heinz, Laghi, Luigi, Grizzi, Fabio, Ohashi, Pamela, Shaw, Patricia, Clarke, Blaise, Wouters, Bradly, Kawakami, Yutaka, Hazama, Shoichi, Okuno, Kiyotaka, Wang, Ena, O'Donnell-Tormey, Jill, Lagorce, Christine, Pawelec, Graham, Nishimura, Michael, Hawkins, Robert, Lapointe, Réjean, Lundqvist, Andreas, Khleif, Samir, Ogino, Shuji, Gibbs, Peter, Waring, Paul, Sato, Noriyuki, Torigoe, Toshihiko, Itoh, Kyogo, Patel, Prabhu, Shukla, Shilin, Palmqvist, Richard, Nagtegaal, Iris, Wang, Yili, d'Arrigo, Corrado, Kopetz, Scott, Sinicrope, Frank, Trinchieri, Giorgio, Gajewski, Thomas, Ascierto, Paolo, Fox, Bernard   +63 more
openaire   +12 more sources

Clinical Significance of a CD3/CD8-Based Immunoscore in Neuroblastoma Patients Using Digital Pathology

Frontiers in Immunology, 2022
BackgroundInfiltrating immune cells have been reported as prognostic markers in many cancer types. We aimed to evaluate the prognostic role of tumor-infiltrating lymphocytes, namely CD3+ T cells, CD8+ cytotoxic T cells and memory T cells (CD45RO+), in ...
Liang Zeng, Shu-Hua Li, Shuo-Yu Xu, Shuo-Yu Xu, Kai Chen, Liang-Jun Qin, Xiao-Yun Liu, Fang Wang, Sha Fu, Ling Deng, Feng-Hua Wang, Lei Miao, Le Li, Na Liu, Ran Wang, Hai-Yun Wang, Hai-Yun Wang   +16 more
doaj   +1 more source

Clinicopathological significance and prognostic role of tumor-infiltrating lymphocytes in colorectal cancer

The International Journal of Biological Markers, 2019
Purpose: This study aimed to elucidate the clinicopathological significance and prognostic role of tumor-infiltrating lymphocytes in colorectal cancer. Methods: The immunohistochemistry of CD3 and CD8 was performed on 265 human colorectal cancer tissues ...
Young San Ko, Jung-Soo Pyo
doaj   +1 more source

Application of the Immunoscore as prognostic tool for hepatocellular carcinoma

Journal for ImmunoTherapy of Cancer, 2016
To date, the American Joint Committee on Cancer (AJCC) and the Union for International Cancer Control (UICC) tumor, nodes, metastasis (TNM) classification represents the standard system for evaluation of prognosis in solid tumors. However, the clinical outcome can be significantly different in patients with the same TNM stage.
Annacarmen Petrizzo, Luigi Buonaguro
openaire   +3 more sources