Results 31 to 40 of about 3,957 (191)

Multi-Institutional Evaluation of Pathologists’ Assessment Compared to Immunoscore

Cancers, 2023
Background: The Immunoscore (IS) is a quantitative digital pathology assay that evaluates the immune response in cancer patients. This study reports on the reproducibility of pathologists’ visual assessment of CD3+- and CD8+-stained colon tumors, compared to IS quantification.
Joseph Willis, Robert A. Anders, Toshihiko Torigoe, Yoshihiko Hirohashi, Carlo Bifulco, Inti Zlobec, Bernhard Mlecnik, Sandra Demaria, Won-Tak Choi, Pavel Dundr, Fabiana Tatangelo, Annabella Di Mauro, Pamela Baldin, Gabriela Bindea, Florence Marliot, Nacilla Haicheur, Tessa Fredriksen, Amos Kirilovsky, Bénédicte Buttard, Angela Vasaturo, Lucie Lafontaine, Pauline Maby, Carine El Sissy, Assia Hijazi, Amine Majdi, Christine Lagorce, Anne Berger, Marc Van den Eynde, Franck Pagès, Alessandro Lugli, Jérôme Galon   +30 more
openaire   +4 more sources

Prognostic significance of immunoscore related markers in bladder cancer

BMC Urology, 2021
Abstract Background The significance of total and specific subpopulations of tumor-infiltrating lymphocytes (TILs) in cancer is now well-documented. In the present study, we investigated the relevance of CD3+, CD8 +, CD45RO +, and FOXP3 + TILs to the prognosis and survival of patients with bladder cancer and the disease ...
Ali Ariafar, Alireza Sanati, Simin Ahmadvand, Golsa Shekarkhar, Akbar Safaei, Zahra Shayan, Zahra Faghih   +6 more
openaire   +3 more sources

Immunoscore Predicts Survival in Early-Stage Lung Adenocarcinoma Patients

Frontiers in Oncology, 2020
Background: The lung cancer staging system is insufficient for a comprehensive evaluation of patient prognosis. We constructed a novel immunoscore model to predict patients with high risk and poor survival.Method: Immunoscore was developed based on z ...
Zihuan Zhao, Zihuan Zhao, Zihuan Zhao, Dan Zhao, Ji Xia, Yi Wang, Yi Wang, Buhai Wang, Buhai Wang   +8 more
doaj   +1 more source

Gene co-expression modules integrated with immunoscore predicts survival of non-small cell lung cancer

Cancer Treatment and Research Communications, 2021
Background: This study aimed to deconvolve the levels of infiltrating immune cells in non-small cell lung cancer (NSCLC) and to identify specific gene co-expression modules associated with prognosis of NSCLC.
Xue-Tao Li, Jia-Tao Zhang, Hong-Hong Yan, Jian Su, Mei-Ling Cheng, Qi-Hui Sun, Wen-Zhao Zhong, Yi-Long Wu, Dr. Xu-Chao Zhang, Dr. Jun Hou   +9 more
doaj   +1 more source

Immunoscore immune checkpoint using spatial quantitative analysis of CD8 and PD-L1 markers is predictive of the efficacy of anti- PD1/PD-L1 immunotherapy in non-small cell lung cancerResearch in context

EBioMedicine, 2023
Summary: Background: Anti-PD-1 and PD-L1 antibodies (mAbs) are approved immunotherapy agents to treat metastatic non-small cell lung cancer (NSCLC) patients. Only a minority of patients responds to these treatments and biomarkers predicting response are
François Ghiringhelli, Frederic Bibeau, Laurent Greillier, Jean-David Fumet, Alis Ilie, Florence Monville, Caroline Laugé, Aurélie Catteau, Isabelle Boquet, Amine Majdi, Erwan Morgand, Youssef Oulkhouir, Nicolas Brandone, Julien Adam, Thomas Sbarrato, Alboukadel Kassambara, Jacques Fieschi, Stéphane Garcia, Anne Laure Lepage, Pascale Tomasini, Jérôme Galon   +20 more
doaj   +1 more source

Impact of Immunoscore on the Management of Stage II Colon Cancer Patients: A Physician Survey

, 2021
Background: Adjuvant chemotherapy use in stage II colon cancer is controversial. Current prognostic risk factors do not take the tumor immune microenvironment into account.
Efrat Dotan, Dewi Vernerey, Graham M. Poage, Anup Kasi, Manju George, Aurelie Catteau, Afsaneh Barzi   +6 more
core   +1 more source

A prognostic value of CD45RA+, CD45RO+, CCL20+ and CCR6+ expressing cells as ‘immunoscore’ to predict cervical cancer induced by HPV

Scientific Reports, 2021
The interplay between cervical cancer (CC) and immune cells, mainly intratumoral lymphocytes, has a pivotal role in carcinogenesis. In this context, we evaluated the distribution of CD45RA+ and CD45RO+ cells as well as CCR6+ and CCL20+ cells in ...
Ana Teresa G. Fernandes, Maria Odete O. Carvalho, Elyzabeth Avvad-Portari, Natália P. Rocha, Fabio Russomano, Eric Henrique Roma, Maria da Gloria Bonecini-Almeida   +6 more
doaj   +1 more source

Immunoscore Combining CD8, FoxP3, and CD68-Positive Cells Density and Distribution Predicts the Prognosis of Head and Neck Cancer Patients

Cells, 2022
We assessed immune cell infiltrates to develop an immunoscore for prognosis and to investigate its correlation with the clinical data of patients with head and neck cancer.
Sonia Furgiuele, Géraldine Descamps, Jerome R. Lechien, Didier Dequanter, Fabrice Journe, Sven Saussez   +5 more
doaj   +1 more source

Clinicopathological Features Combined With Immune Infiltration Could Well Distinguish Outcomes in Stage II and Stage III Colorectal Cancer: A Retrospective Study

Frontiers in Oncology, 2021
BackgroundThe Immunoscore predicts prognosis in patients with colorectal cancer (CRC). However, a few studies have incorporated the Immunoscore into the construction of comprehensive prognostic models in CRC, especially stage II CRC.
Jiazi Ren, Linfeng Xu, Linfeng Xu, Siyu Zhou, Jian Ouyang, Weiqiang You, Nengquan Sheng, Li Yan, Du Peng, Lu Xie, Zhigang Wang   +10 more
doaj   +1 more source

Clinical Significance of a CD3/CD8-Based Immunoscore in Neuroblastoma Patients Using Digital Pathology

Frontiers in Immunology, 2022
BackgroundInfiltrating immune cells have been reported as prognostic markers in many cancer types. We aimed to evaluate the prognostic role of tumor-infiltrating lymphocytes, namely CD3+ T cells, CD8+ cytotoxic T cells and memory T cells (CD45RO+), in ...
Liang Zeng, Shu-Hua Li, Shuo-Yu Xu, Shuo-Yu Xu, Kai Chen, Liang-Jun Qin, Xiao-Yun Liu, Fang Wang, Sha Fu, Ling Deng, Feng-Hua Wang, Lei Miao, Le Li, Na Liu, Ran Wang, Hai-Yun Wang, Hai-Yun Wang   +16 more
doaj   +1 more source