Results 111 to 120 of about 29,033 (245)

Age-related changes in blood-brain barrier integrity in C57BL/6J mice [PDF]

, 2013
The blood-brain barrier (BBB) is formed by the endothelial cells of the brain microvasculature, which control the molecular traffic between the blood and brain to maintain the neural ...
Romero, I. A., Saffrey, M. J., Wang, C.
core  

Temporal Changes in Key Hematological and Inflammatory‐Immune Markers Among Elderly Patients Following Hip Fracture: A Five‐Day Serial Assessment

Orthopaedic Surgery, EarlyView.
This study found that key hematological parameters showed temporal patterns: hemoglobin, hematocrit, neutrophil percentage, neutrophils, and NLR significantly decreased from days 1 to 5 (all p < 0.001), while lymphocytes and monocytes exhibited biphasic dynamics. Monocytes had a significant interaction with time and fracture type, while lymphocytes and
Yuening Han, Shanshan Zhang, Xinqun Cheng, Yuqing Li, Chengsi Li, Yingze Zhang, Yanbin Zhu, Cici Bai, Xiuting Li   +8 more
wiley   +1 more source

Research Progress on Immunosenescence in Elderly Patients 
with Advanced Non-small Cell Lung Cancer and Its Immunotherapy

Chinese Journal of Lung Cancer
Lung cancer remains the leading cause of cancer-related incidence and mortality worldwide. Among its histological subtypes, non-small cell lung cancer (NSCLC) accounts for the majority of cases, representing the predominant pathological type. Notably, in
Na WANG, Yaning LUO, Haoyu LU, Siyuan CUI, Kui ZHAO, Fanming KONG   +5 more
doaj   +1 more source

T Cell Immunosenescence after Early Life Adversity: Association with Cytomegalovirus Infection

Frontiers in Immunology, 2017
Early life adversity (ELA) increases the risk for multiple age-related diseases, such as diabetes type 2 and cardiovascular disease. As prevalence is high, ELA poses a major and global public health problem.
Martha M. C. Elwenspoek, Martha M. C. Elwenspoek, Krystel Sias, Xenia Hengesch, Violetta K. Schaan, Fleur A. D. Leenen, Fleur A. D. Leenen, Philipp Adams, Sophie B. Mériaux, Stephanie Schmitz, Fanny Bonnemberger, Anouk Ewen, Hartmut Schächinger, Claus Vögele, Claude P. Muller, Claude P. Muller, Jonathan D. Turner   +16 more
doaj   +1 more source

Therapeutic Strategies and Clinical Outcomes of Infections Following Anterior Cruciate Ligament Reconstruction: A Narrative Review

Orthopaedic Surgery, EarlyView.
ACL reconstruction‐associated infections threaten graft integrity and joint function. This review summarizes patient‐related risk factors, approaches, and treatment strategies, with emphasis on early recognition and preventive measures such as vancomycin presoaking.
Shaoli Zhang, Jue Gong
wiley   +1 more source

Immunosenescence in HIV Pathogenesis

Virology, 1997
Telomeres are complex protein-DNA structures located at the ends of eukaryotic chromosomes. In a normal cell, telomere DNA shortens with cell divisions. Such a telomere loss may act as a mitotic clock to eventually signal cell cycling exit and cellular senescence. In a transversal study, we found a marked decrease in telomere length of peripheral blood
Pommier, Jean-Patrick, Gauthier, Laurent, Livartowski, Joêl, Galanaud, Pierre, Boué, François, Dulioust, Anne, Marcé, Dominique, Ducray, Caroline, Sabatier, Laure, Lebeau, Jérôme, Boussin, François-Dominique   +10 more
openaire   +2 more sources

Genetic risk variants implicate impaired maintenance and repair of periodontal tissues as causal for periodontitis—A synthesis of recent findings

Periodontology 2000, EarlyView.
AbstractPeriodontitis is a complex inflammatory disease in which the host genome, in conjunction with extrinsic factors, determines susceptibility and progression. Genetic predisposition is the strongest risk factor in the first decades of life. As people age, chronic exposure to the periodontal microbiome puts a strain on the proper maintenance of ...
Arne S. Schaefer, Luigi Nibali, Noha Zoheir, Niki M. Moutsopoulos, Bruno G. Loos   +4 more
wiley   +1 more source

TB and HIV induced immunosenescence: where do vaccines play a role?

Frontiers in Aging
This paper tackles the complex interplay between Human Immunodeficiency virus (HIV-1) and Mycobacterium tuberculosis (M. tuberculosis) infections, particularly their contribution to immunosenescence, the age-related decline in immune function.
Mona Singh, Bhumika Patel, Michael Seo, Phillip Ahn, Nejma Wais, Haley Shen, SriHarsha Nakka, SriHarsha Nakka, Priya Kishore, Vishwanath Venketaraman   +9 more
doaj   +1 more source

The Role of Belatacept‐Use and Senescence on Infectious and Mortality Complications After Kidney Transplantation

Transplant Infectious Disease, EarlyView.
ABSTRACT Introduction Studies evaluating the incidence of infections after belatacept as a substitute for calcineurin inhibitors (CNI) or antimetabolite in kidney transplant (KT) yielded conflicting results. We compared infectious outcomes after belatacept‐use to no belatacept‐use in KT recipients.
Hareesh Singam, Abdinoor Abdi, Wyatt Tarter, Ben Langworthy, Adam Bregman, Karam M. Obeid   +5 more
wiley   +1 more source

Deciphering the impact of TERT/telomerase on immunosenescence and T cell revitalization

Frontiers in Immunology
Immunosenescence impacts both the innate and adaptive immune systems, predominantly affecting certain immune cell types. A notable manifestation of immunosenescence is the diminished efficacy of adaptive immunity. The excessive senescence of immune cells,
Lingyi Huang, Mingfu Zhang, Ding Bai, Yi Qu   +3 more
doaj   +1 more source