Results 141 to 150 of about 29,033 (245)

Single‐Cell Profiling of Splenic Immune Ageing and Chronic Stress Adaptations in Mice With Natural Microbiota

European Journal of Immunology, Volume 56, Issue 3, March 2026.
Mice with natural microbiota show expected ageing spleen trends: naïve T cell loss with effector‐memory expansion, mature B cell shifts, Gzmk+ CD8+ T cell heterogeneity, diminished NK cytotoxicity and pro‐inflammatory macrophages. Chronic stress modestly counteracted these age‐related changes.
Chinna Susan Philip, Igor Filippov, Uku Haljasorg, Pärt Peterson   +3 more
wiley   +1 more source

Healthcare Development, Relaxed Natural Selection, and COVID‐19 Infection Rates: An Evolutionary Population‐Level Analysis

Health Science Reports, Volume 9, Issue 3, March 2026.
ABSTRACT Background and Aim Evolutionary principles offer critical insights into pandemic dynamics but have been largely overlooked in contemporary responses to COVID‐19. Relaxed natural selection, increased global mobility, and lifestyle mismatches have contributed to human vulnerability to infectious diseases in modern societies.
Wenpeng You, Brendon Coventry, Arthur Saniotis, Francesco Maria Galassi, Renata Henneberg, Maciej Henneberg   +5 more
wiley   +1 more source

Cellular Immune Response Induced by mRNA Vaccines Against SARS‐CoV‐2

Immunity, Inflammation and Disease, Volume 14, Issue 3, March 2026.
SARS‐CoV‐2 vaccine induces cellular immune response. T‐cells play a protective role for COVID‐19. ABSTRACT The disease caused by SARS‐CoV‐2 is known as COVID‐19, and it can range from mild symptoms to severe clinical manifestations, including respiratory failure, pneumonia, and organ failure. Since its emergence in 2019, more than 7 million deaths have
Valentina Tovar, Isaura Pilar Sánchez, María Teresa Rugeles, Natalia Andrea Taborda, Juan C. Hernandez   +4 more
wiley   +1 more source

Global Burden of Hematologic Malignancies From 1990 to 2021 With Projections to 2030: A Systematic Analysis for the Global Burden of Disease Study 2021

iNew Medicine, Volume 2, Issue 1, March 2026.
ABSTRACT This study aimed to comprehensively analyze the epidemiological trends and global burden of hematologic malignancies (HM) from 1990 to 2021 and to project trends up to the year 2030. Using data from the Global Burden of Disease (GBD) Study 2021, we analyzed the age‐standardized rates (ASRs) and the trends of HM from 1990 to 2021. Decomposition
Ziyuan Shen, Linyu Huang, Xing Xing, Danting Zhang, Guoqi Cai, Wei Sang   +5 more
wiley   +1 more source

Differential associations of anti-cytomegalovirus antibodies and soluble CD14 levels with immunosenescence in people living with HIV on long term antiretroviral therapy

Immunity & Ageing
Background People living with HIV (PLHIV) demonstrate accelerated aging and immunosenescence in spite of immune-restoration following long-term antiretroviral treatment (ART).
Ashwini Vinod Shete, Pallavi Shidhaye, Amrita Rao, Nikita Bhawari, Supriya Deshpande, Jyoti Sawant, Rajani Bagul, Ujjwala Ghule, Sunita Kumbhar, Manisha Ghate   +9 more
doaj   +1 more source

Age‐related changes of oxidative status and immune function in a long‐lived seabird

Journal of Avian Biology, Volume 2026, Issue 2, March 2026.
Experimental studies in humans and laboratory species have shown that the decline of the immune system with age (immunosenescence) and the accumulation of oxidative damage to macromolecules are two key contributors to the onset and progression of the ageing process. Although laboratory models have provided important insights, the physiological basis of
Beatrice Berardi, Giacomo Dell'Omo, Gianluca Damiani, Gábor Á. Czirják, Silvia Filippi, Claudio Carere, David Costantini   +6 more
wiley   +1 more source

Varicella Zoster Virus Infection: Clinical Features, Molecular Pathogenesis, Treatment, and Prevention

MedComm, Volume 7, Issue 3, March 2026.
This review focuses on the clinical features, molecular mechanisms, treatment methods, and preventive measures of the VZV, with the aim of providing a theoretical basis for the development of new treatment and prevention methods for HZ. ABSTRACT Varicella zoster virus (VZV) is a ubiquitous human herpesvirus that establishes lifelong latency and causes ...
Lei Peng, Honghao Song, Tianying Li, Yuqing Ma, Chen Yan, Yuhan Cao, Kaiqiang Sun, Chaofeng Han, Hongbin Yuan   +8 more
wiley   +1 more source

sCD163, sCD28, sCD80, and sCTLA-4 as soluble marker candidates for detecting immunosenescence

Immunity & Ageing
Background Inflammaging, the characteristics of immunosenescence, characterized by continuous chronic inflammation that could not be resolved. It is not only affect older people but can also occur in young individuals, especially those suffering from ...
Andrea Aprilia, Kusworini Handono, Hidayat Sujuti, Akhmad Sabarudin, Nuning Winaris   +4 more
doaj   +1 more source

Age is the work of art? : impact of neutrophil and organism age on neutrophil extracellular trap formation [PDF]

, 2017
Elzbieta Kolaczkowska, Weronika Ortmann
core   +1 more source

Aging‐Derived Alterations in Genomic, Immune, and Metabolic Networks: Implications for Cancer Development and Therapy

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Ageing acts as a double‐edged sword in cancer. In the elderly, open chromatin, immunosenescence, and chronic inflammation drive SASP (IL‐6, MMPs), MDSC accumulation and T‐cell suppression, fostering tumor‐promoting microenvironments and limited therapeutic benefit.
Qi Wang, Xue Sun, Xinhao Han, Xingda Zhang, Wenzheng Wang, Hongbin Wang, He Ren, Lina Gu   +7 more
wiley   +1 more source